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Propionate Clobetasol; a PGD2 antagonist


#1

before and after using propionate clobetasol foam for 6 months

source:http://www.sciencedirect.com/science/article/pii/S0190962203007795

and proof that PC foam is a PGD2 antagonist:

http://www.patentstorm.us/applications/20110034558/description.html


#2

» http://www.patentstorm.us/applications/20110034558/description.html

another, more recent, study:

Before-After:


#3

Good work at connecting the dots here… How did you find all of this?

True, the study cited in ScienceDirect has to do with “alopecia totalis/universalis”, which is a very rare and weird autoimmune (?) disease where people lose almost all the hair on their bodies.

However, the connection of this stuff clobetasol, with PGD2, is amazing and unexpected.

First, I wonder if this was the impetus for Dr. Cotsarelis and Dr. Garza to do their study on PGD2/PGD2 Synthase in MPB. I realize in their DNA studies of balding tissue, they screened for a very wide array of genes. But I can’t help but think Dr. Cotsarelis was aware of stuff like this and designed the study so that it would “discover” PGD2.

Second, if this is true, then this connection has been languishing out there for at least 10 years already and nobody in the medical community – with the exception of Drs. Cotsarelis and Garza – had the good sense or the professional dedication make the connection with MPB.

This shows how much most of the medical community really cares about MPB.


#4

It’s late and I didn’t really have time to read through the links in detail but if what you are suggesting is true, then I find this very intriguing…!!

» » http://www.patentstorm.us/applications/20110034558/description.html
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» another, more recent, study:
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» http://informahealthcare.com/doi/abs/10.3109/09546634.2011.590788
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» Before-After:
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#5

Needhairasap, where in that patent does it say that the subject molecule, [2-(3-benzyl-1-ethyl-ureidomethyl)-6-methoxy-4-trifluoromethyl-biphenyl-3-yl]-acetic acid, is the same thing as “Propionate Clobetasol”?

I trust your research, but it looks like you’ve posted a whole lot of information without filling in the blanks.


#6

» Needhairasap, where in that patent does it say that the subject molecule,
» [2-(3-benzyl-1-ethyl-ureidomethyl)-6-methoxy-4-trifluoromethyl-biphenyl-3-yl]-acetic
» acid, is the same thing as “Propionate Clobetasol”?
»
» I trust your research, but it looks like you’ve posted a whole lot of
» information without filling in the blanks.

That compound is also know as AM211. Here is the detail…


#7

» That compound is also know as AM211. Here is the detail…
»
» http://jpet.aspetjournals.org/content/338/1/290.long

thanks, mlouis.


#8

Following up on that info on AM211…

There are currently THREE selective CRTH2 antagonists being investigated:

  1. AM-211 by Amira Pharmaceuticals

  2. AM-156 by Amira Pharmaceuticals

  3. MK-7246 by Merck Pharmaceuticals

Now, Phase I for MK-7246 in Asthma has already been completed. They’re also developing other analogues of MK-7246 as back up in case MK-7246 is not effective in Phase IIa trials.


#9

What happened to this?
The photos look very intriguing, again I know it is Totalis, but still…
I wonder what happened to PGD2 more generally, for me it has completely stopped my shedding which I was having for 10 years (for 6 months in a row for now, knocking on wood…)


#10

Cotsarelis hinted in his pgd2 2012 paper that prostanglandins could be involved in more than one form of hairloss(any PG not just pgd2). I have been waiting for him to start his trials I hope it is still going ahead.


#11

It is kind of disturbing that no company has announced trials for hairloss yet. Normally as with Minox, Finasteride, etc., big pharma companies are eager to put out press releases about major drug trials.


#12

[quote][postedby]Originally Posted by waynakyo[/postedby]
I wonder what happened to PGD2 more generally, for me it has completely stopped my shedding which I was having for 10 years (for 6 months in a row for now, knocking on wood…)[/quote]

How are you inhibiting PGD2?


#13

OC of course, see the Help forum…it works, people are just being cheap, i can t believe they complain so much about the price but are willing to try unproven and weird treatments.
I think recently i started to regrow some but i will hold on on this to see clear evidence (pictures) before confirming…to me OC works even better than RU.
Ceterezine and company were not strong enough and had side effects


#14

I’m not sure which thread you’re referring to. What is OC?