Progesterone Before and After 4 and 5 months (I think)

» Where are the studies that say progesterone can reverse hair loss?
» can someone post here?

Here are some comments from a well-known authority in dermatology, Dr. Norman Orentreich, in his article: “Biology of Scalp Hair Growth”, Clinics in Plastic Surgery – Vol. 9, No. 2, 1982:

"Local Therapy
[…] Progesterone was found to be a natural and significant 5aR inhibitor when tested in vitro, in the human skin microsome system, a rich source of 5aR, and in human scalp hair follicles. When a solution of progesterone in alcohol was applied to the pubic skin of normal males, it caused an average decrease of 75.2 per cent in 5aR activity after 24 hours of treatment.

"Moreover, while less DHT is made, more dihydroprogesterone (DHP; 5a-pregnane-3,20dione) is made. DHP competes with the residual DHT for the cytosol-nuclear binding protein for a further reduction in the amount of DHT interacting with genetic material.

"Progesterone works in reducing DHT production locally by competing for the active site of 5aR and would need to be present at the active site continuously because of the reversible kinetics. Treatment lapses result in the resumption of DHT production from testosterone.

"Since progesterone only partially inhibits DHT production and since DHP only partially inhibits binding of residual DHT, local progesterone at best can only ameliorate androgenetic alopecia and not arrest it.

“Because more than 70 per cent of topically applied progesterone is metabolized in the skin to weak, nonandrogenic by-products, it can be used in women at the rate of 1 ml of a 2 per cent solution BID, whereas higher doses result in menstrual irregularities.”

Also, this would be a good place to mention what Sawaya and Shapiro said in their review article “Alopecia: Unapproved Treatments or Indications”, Clinics in Dermatology 2000;18:177-186: “Most therapeutic indications for progesterone are for ovarian disorders and contraception. Off-label uses have indicated variable effectiveness as a topical agent for treating AGA at 2% concentrations. We have not found that topical progesterone is of great value in the treatment of AGA”.

So it looks like topical progesterone might help a little, but it’s nothing to write home about.

.

» » Where are the studies that say progesterone can reverse hair loss?
» » can someone post here?
»
» Here are some comments from a well-known authority in dermatology, Dr.
» Norman Orentreich, in his article: “Biology of Scalp Hair Growth”, Clinics
» in Plastic Surgery – Vol. 9, No. 2, 1982:
»
» "Local Therapy
» […] Progesterone was found to be a natural and significant 5aR inhibitor
» when tested in vitro, in the human skin microsome system, a rich source of
» 5aR, and in human scalp hair follicles. When a solution of progesterone in
» alcohol was applied to the pubic skin of normal males, it caused an average
» decrease of 75.2 per cent in 5aR activity after 24 hours of treatment.
»
» "Moreover, while less DHT is made, more dihydroprogesterone (DHP;
» 5a-pregnane-3,20dione) is made. DHP competes with the residual DHT for the
» cytosol-nuclear binding protein for a further reduction in the amount of
» DHT interacting with genetic material.
»
» "Progesterone works in reducing DHT production locally by competing for
» the active site of 5aR and would need to be present at the active site
» continuously because of the reversible kinetics. Treatment lapses result
» in the resumption of DHT production from testosterone.
»
» "Since progesterone only partially inhibits DHT production and since DHP
» only partially inhibits binding of residual DHT, local progesterone at best
» can only ameliorate androgenetic alopecia and not arrest it.
»
» “Because more than 70 per cent of topically applied progesterone is
» metabolized in the skin to weak, nonandrogenic by-products, it can be used
» in women at the rate of 1 ml of a 2 per cent solution BID, whereas higher
» doses result in menstrual irregularities.”
»
»
» Also, this would be a good place to mention what Sawaya and Shapiro said
» in their review article “Alopecia: Unapproved Treatments or Indications”,
» Clinics in Dermatology 2000;18:177-186: “Most therapeutic indications for
» progesterone are for ovarian disorders and contraception. Off-label uses
» have indicated variable effectiveness as a topical agent for treating AGA
» at 2% concentrations. We have not found that topical progesterone is of
» great value in the treatment of AGA”.
»
» So it looks like topical progesterone might help a little, but it’s
» nothing to write home about.
»
» .

afaik there are only very few studies about progesterone and aga. and the only one I was able to dig out said it halted aga progression only, but they did it only at the back of the head not in the temples afaik.

There is also that study that says that progesterone was almost the same effective in DHT inhibition as finasteride (when the same concentration was used).

all in all :slight_smile: you dont have to write home about it. we are now 2 (prague and me) who are growing temples back. and guess what, woman in general do not lose temples but rather thin all over. isnt it interesting?

» they tested it at the back of the head not in the temples afaik.

Do you think that speaks FOR or AGAINST the use of topical progesterone? :slight_smile:

» » they tested it at the back of the head not in the temples afaik.
»
» Do you think that speaks FOR or AGAINST the use of topical progesterone?
» :slight_smile:

I think it is obvious that temples and crown do differ and react differently to treatments. Imho there is more to it than just more receptors. All in all, if I’m growing temples back on pg, and if temples were really just harder to regrow and there was nothing unique to them, then I dont even want to know what kind of afro hairdo would I get if I applied it to the crown.

Anyway I do not believe that there is nothing unique to the temples. Simply because women have different pattern, then we do, and the difference is mainly the temples, and the severity of the overall thnning.

So if you accept that there may be something special to the temples, then it makes sense to test treatments on both areas and do not dismis something just because someone says it merely halted hairloss in the crown.

Completely other thing is credibility of the studies, for example tehre is that study that says it inhibits dht as effective as fin. this kinda contradicts the study that says that in the crown it just stopped loss.

So we have contradiction of two studies here. And to be honest I do not care much, results are what I’m after, why it works is an interesting question but I do not care much rly as long as it works.

» So if you accept that there may be something special to the temples, then
» it makes sense to test treatments on both areas and do not dismis something
» just because someone says it merely halted hairloss in the crown.

My assumption would be that it’s more difficult to regrow hair (or simply stop hair loss) in the temple area than the crown, so if a certain treatment only works so-so in the crown, it’s unlikely to do much good in the temples.

» Completely other thing is credibility of the studies, for example tehre
» is that study that says it inhibits dht as effective as fin.

Which study is that?

.

I think you’re assuming too much. I tend to try things before dismissing them.

============================================

Here’s the study

Influence of estrogens on the androgen metabolism in different subunits of human hair follicles

European Journal of Dermatology. Volume 11, Number 3, 195-8, May - June 2001, Revues

Summary

Author(s) : S. Niiyama, R. Happle, R. Hoffmann, Department of Dermatology, Philipp University, Deutschhausstraße 9, D-35033 Marburg, Germany…

Summary : The molecular pathways involved in estrogen-mediated induction of hair growth in androgenetic alopecia are unknown. Some authors found that estradiol (E) inhibited 5alpha-reductase (5alpha-R) activity and therefore we addressed the question whether 17alpha- or 17beta-E are able to modulate the activity of 5alpha-R, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) or 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in isolated compartments of human hair follicles. For this purpose, scalp biopsies from volunteers were taken and from each biopsy root sheaths, connective tissue sheaths and dermal papillae (DP) were dissected and incubated in the presence of 3H-testosterone (T) and, in addition, either 17alpha-E, 17beta-E, progesterone or finasteride for up to 48 hrs. Thereafter high-performance liquid chromatography analysis of culture supernatants was performed to detect T-metabolites. At the tested concentrations, finasteride was found to be a major inhibitor of dihydrotestosterone (DHT) formation. Even 1 nM finasteride inhibited DHT synthesis in DP by 86% and 1 nM progesterone by 75%. Estrogens were less able to inhibit the synthesis of DHT in DP (e.g. 100 nM 17alpha-E: 20%; 100 nM 17beta-E: 60%). Whether E directly inhibits 5alpha-R in DP’s or whether the effect of estrogens might be explained by an increased conversion of T to the weaker androgens such as androstendione (via 17beta-HSD), androstenediol (via 3beta-HSD) or 17beta-E (via aromatase), thereby diminishing the amount of T available for the conversion to DHT, remains to be shown.

http://www.jle.com/en/revues/medecine/ejd/e-docs/00/01/89/4F/article.md

======================================

wikipedia says:

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor[1] which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone.[2] The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.[3][4]

======================================

Progestin is a synthetic stuff with effect similar to natural progesterone, basicaly the stuff in the cream.

======================================

And some other stuff here

http://www3.interscience.wiley.com/journal/119036281/abstract

http://www.jstage.jst.go.jp/article/cpb/49/9/49_1081/_article/-char/en

» I think you’re assuming too much. I tend to try things before dismissing
» them.

I’m certainly not “dismissing” anything. I just think it’s fairly safe to assume that hair products don’t work as well in the front as they do on the crown.

» Here’s the study
»
» Influence of estrogens on the androgen metabolism in different subunits of
» human hair follicles
»
» European Journal of Dermatology. Volume 11, Number 3, 195-8, May - June
» 2001, Revues

Okay, thanks. I’ve already read that, I just didn’t know which study you were referring to.

.

» I probably should have :slight_smile:

You are welcome. Keep us posted.

» » I probably should have :slight_smile:
»
» You are welcome. Keep us posted.

Can topical progesterone cause gyno in men ? i thought it was a female hormone.

Progesterone has both antiandrogen and antiestrogenic properties.

http://www3.interscience.wiley.com/journal/109880980/abstract?CRETRY=1&SRETRY=0

» Progesterone has both antiandrogen and antiestrogenic properties.
»
» http://www3.interscience.wiley.com/journal/109880980/abstract?CRETRY=1&SRETRY=0

hi,
the link is broken (i get a cookie error). So does that mean yes or … no ?

thanks

www.progesterone.co.uk

its better then the swansons brand, its much softer and dries much more easily.

Another source -

www.zrtlab.com/File.ashx?cid=832

» » Progesterone has both antiandrogen and antiestrogenic properties.
» »
» »
» http://www3.interscience.wiley.com/journal/109880980/abstract?CRETRY=1&SRETRY=0
»
» hi,
» the link is broken (i get a cookie error). So does that mean yes or … no
» ?
»
» thanks

thanks

still, i dont know if it could cause gyno if you take it topically althought it seems that it is an anti-eostrogen. But im no specialist so i dont know…can it cause gyno ? :stuck_out_tongue:
thanks

Could you please post the complete link within http://www.swansonvitamins.com of exactaly which progesterone cream you are using?

Thanks.

» www.progesterone.co.uk
»
» its better then the swansons brand, its much softer and dries much more
» easily.

Hey ‘Debris’.

I’m quite glad I found your post on here and it has really got me thinking. I was about to purchase Dr Kleins REMOX starter kit ($133), do you recon his starter kit combined with progesterone would be a good idea? It’s my temple area that I’m worried about…at least for now anyway.

Well done to you on your hair progress :slight_smile:

» » www.progesterone.co.uk
» »
» » its better then the swansons brand, its much softer and dries much more
» » easily.
»
» Hey ‘Debris’.
»
» I’m quite glad I found your post on here and it has really got me
» thinking. I was about to purchase Dr Kleins REMOX starter kit ($133), do
» you recon his starter kit combined with progesterone would be a good idea?
» It’s my temple area that I’m worried about…at least for now anyway.
»
» Well done to you on your hair progress :slight_smile:

Hi. I dunno much about remox starter kit. I dont have any personal experience with it nor I know anyone whose using it so I cant tell rly.

Progesterone is a good idea. My temples have improved even further. I will post some update later again.

Could you please post the complete link within http://www.swansonvitamins.com of exactaly which progesterone cream you are using?

Thanks.

» » » www.progesterone.co.uk
» » »
» » » its better then the swansons brand, its much softer and dries much
» more
» » » easily.
» »
» » Hey ‘Debris’.
» »
» » I’m quite glad I found your post on here and it has really got me
» » thinking. I was about to purchase Dr Kleins REMOX starter kit ($133),
» do
» » you recon his starter kit combined with progesterone would be a good
» idea?
» » It’s my temple area that I’m worried about…at least for now anyway.
» »
» » Well done to you on your hair progress :slight_smile:
»
» Hi. I dunno much about remox starter kit. I dont have any personal
» experience with it nor I know anyone whose using it so I cant tell rly.
»
» Progesterone is a good idea. My temples have improved even further. I will
» post some update later again.

That’s great news!

I’ve ordered a jar from the UK seller. Also going to order some Maca powder - I also came across this article regarding Maca and hairloss/growth:
http://www.totalityofbeing.com/FramelessPages/Articles/real_reason_men_lose_hair.htm

Thanks again.

» » » » www.progesterone.co.uk
» » » »
» » » » its better then the swansons brand, its much softer and dries much
» » more
» » » » easily.
» » »
» » » Hey ‘Debris’.
» » »
» » » I’m quite glad I found your post on here and it has really got me
» » » thinking. I was about to purchase Dr Kleins REMOX starter kit ($133),
» » do
» » » you recon his starter kit combined with progesterone would be a good
» » idea?
» » » It’s my temple area that I’m worried about…at least for now anyway.
» » »
» » » Well done to you on your hair progress :slight_smile:
» »
» » Hi. I dunno much about remox starter kit. I dont have any personal
» » experience with it nor I know anyone whose using it so I cant tell rly.
» »
» » Progesterone is a good idea. My temples have improved even further. I
» will
» » post some update later again.
»
» That’s great news!
»
» I’ve ordered a jar from the UK seller. Also going to order some Maca
» powder - I also came across this article regarding Maca and
» hairloss/growth:
» Totalityofbeing.com
»
» Thanks again.

Good news, my progesterone cream arrived this morning. Better get started!