They discontinued UK-157147 that was in phase 2 trials.
They discontinued PF-277243 and PF-3004459 that were in Phase 1 trials.
My take-------------they had stumbled onto some compounds that they were studying for other things that had a hypertrichotic side effect. They knew they were safe, because they were “in” other drugs, so they made little derivatives of them and had human tests…and found that they were no more effective than existing stuff (minoxidil) or worked by pretty much the same mechanisms (opening potassium channels, sulfanyl recptor blockage that inhibtis tgf-beta to some extent, ups some interleukin or whatever). What they had wasn’t good enough to justify the expensive phase three trial in all likelihood. A company like phfizer wouldn’t even let an indication get into human testing if it didn’t show promise in some lab rat.
Now, to my knowledge, AJCS-9, is the only thing other than Dutasteride (in Korea in phase 2 trials for baldness now) that is being testing medically as a “treatment” for alopecia in the “drug” sense. Its ICX, Follica, or NOTHING guys.
That AJCS-9 should be very good for keeping what you have. It does seem to be one hell of a side-effect free anti-androgen as curcumin was as effective as gamma linolenic acid was in hamster flank organ tests as an anti-androgen. If it really is side-effect free, doesnt get absorbed in the bloodstream, and doesnt smell like curry sauce or stain your scalp yellow as curcumin does (they say it doesnt), it would be a good way to fight further baldness anyway.
Like I said…within the next year or two we will know if we will be getting lost hair back, or whether it would be best just to forget about it because it will be a wait until gene therapy (decade or two at least). There is nothing else coming down the pike in hair in the near term other than what we have now that I know of. No research, nada…