Titre du document / Document title
Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells
Auteur(s) / Author(s)
BYUNG HA CHUNG ; LEE Hye-Young ; JAE SEOK LEE ; YOUNG Charles Y. F. ;
Résumé / Abstract
Perillyl alcohol is a hydroxylated monocyclic monoterpene. In animal study, monoterpene has shown to have an anti-tumor effect. The aim of this study is to evaluate whether POH plays an important role in the development and progression of prostate cancer (pCa). We treated LNCaP cells with different concentrations of perillyl alcohol (POH). First of all, we performed cell proliferation assay and prostate-specific antigen (PSA) and human glandular kallikrein (hK2) quantification assays. LNCaP cells were treated with or without POH for Western blot analysis of androgen receptor (AR) and c-Jun. Finally, we performed transient transfection assay by transfecting LNCaP cells-which were treated with or without POH-with pGL-3 luciferase vector containing PSA promoter and AR promoter. We observed inhibition of the expression and function of the AR by POH. through inhibition of androgen-induced cell growth and androgen-stimulated secretion of prostate-specific antigen and hK2, in human pCa cell line LNCaP. In addition, we demonstrated, for the first time, that POH inhibits the transcription activities of the AR gene promoter by over-expression of c-Jun protein. These novel properties of POH strongly suggest that POH could be highly useful for intervention of pCa.
Revue / Journal Title
Cancer letters ISSN 0304-3835 CODEN CALEDQ
Source / Source
2006, vol. 236, no2, pp. 222-228 [7 page(s) (article)]
Langue / Language
Editeur / Publisher
Elsevier, Shannon, IRLANDE (1975) (Revue)
Mots-clés d’auteur / Author Keywords
Perillyl alcohol ; Androgen receptor ; Prostate carcinoma cell line LNCaP ;
Localisation / Location
INIST-CNRS, Cote INIST : 17217, 35400015310684.0080
Sources of perillyl alcohol:
l-perillyl alcohol, monoterpene, monoterpene perillyl alcohol, perilla, perillic acid, POH.
Perillyl alcohol is isolated from the essential oils of several plants including cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, savin juniper, Conyza newii, caraway, Perilla frutescens, and wild bergamont.
Animal studies suggest that perillyl alcohol may help slow growth of pancreatic, mammary, and liver tumors. It may also help colon, lung, and skin cancer. Perillyl alcohol is under sponsorship from the National Cancer Institute (NCI), and is undergoing phase II clinical trials."