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New research finds way to restore hair colour


#1

More of the same?

Extracted from Manchester Univ. web page. http://www.manchester.ac.uk/aboutus/news/display/?id=4162

New research finds way to restore colour to white hair following illness
13 Nov 2008

Scientists have discovered a way to potentially restore colour to white hair, new research in the British Journal of Dermatology reveals this month.
A number of skin disorders cause the hair to fall out, and when it re-grows, it is often white. For many patients, this is almost as distressing as the initial hair loss.

Melanin, the pigment in skin and hair, is stimulated by a group of peptide hormones collectively known as ‘melanocyte stimulating hormone’ or MSH.

Researchers at The University of Manchester and in Germany therefore examined whether a peptide called K(D)PT, which can be synthetically produced in the laboratory and is related to MSH, might have the same pigmentation stimulating effects as the naturally occurring MSH, and whether this could be used to restore colour to white hair after illness.

The team treated normal, isolated hair follicles from six women aged between 46 and 65 with different concentrations of K(D)PT. The research was carried out in the laboratory as it is not yet ready for direct use on patients.

In some of the test groups, the follicles were first treated with ‘Interferon type II’, commonly known as IFN-y, a proinflammatory stimulus that is linked to certain autoimmune disorders. The purpose of this was to mimic the sort of inflammation that is present in disorders that cause the hair to fall out, including ‘alopecia areata’, a skin disease that causes hair loss, and ‘telogen effluvium’, a disorder that causes thinning of the hair, often after an accident, illness or extreme stress on the body.

Hair frequently loses colour after this sort of inflammation, so that when the hair returns, it is often white, regardless of its colour prior to hair loss.

The test groups were either pre-treated with IFN-g then given K(D)PT, pre-treated with K(D)PT then IFN-y, treated with K(D)PT alone, treated with IFN-y alone, or in the case of the control group, treated with distilled water.

The study found that K(D)PT increased the amount of melanin (pigment) in the hair follicle significantly when administered after pre-treatment with IFN-y.

This pre-treatment with a proinflammatory stimulus appeared to be necessary for the pigment effect to occur, as it was absent in the group where K(D)PT was administered first and IFN-g second. Likewise, IFN-y alone inhibited rather than stimulated pigment production, and K(D)PT used alone did not significantly alter the hair pigmentation. It is thought that as yet unknown receptors for K(D)PT are elevated or present only in tissue inflamed by substantial IFN-y activity.

As the purpose of pre-treating with IFN-y was to mimic the sort of inflammatory changes that may contribute to hair turning white, to then see whether K(D)PT could restore the hair colour, these findings are of particular use to the treatment of hair that has turned white following illness.

The study’s senior author Dr Ralf Paus, of the University of Lübeck, Germany, and the School of Translational Medicine at the University of Manchester, said: “Since this tripeptide displays interesting hair pigmentation-stimulatory activities under proinflammatory conditions, clinically, K(D)PT deserves to be explored as an innovative new anti-greying agent.

“Specifically, topical application of K(D)PT may become exploitable for the treatment of postinflammatory hair whitening that is often seen during the recovery phase of alopecia areata.”

Nina Goad of the British Association of Dermatologists said: “It’s important to note that this is laboratory research and not yet ready for use on patients. However, while the research is still at a very early stage, these findings could potentially pave the way for new therapies that restore colour to white hair. At the moment, this research only applies to people whose hair has turned white following illness, but this is an important step for such patients.”

At this early preclinical stage, it is not possible to say for definite if it would restore hair to its full, original colour, although this is thought to be a reasonable possibility. However, there may indeed be patients whose hair follicle pigmentary system has been damaged beyond repair, who might not profit at all from such a treatment. Most likely, treatment would have to be re-administered, as long as the pro-inflammatory stimulus that caused hair whitening persists.

Ends

Notes for editors
It is not possible to say whether the results could also apply to chemotherapy patients, since no chemotherapeutic agent was tested in these currently reported preclinical assays.

Articles in the BJD can be viewed online: http://www3.interscience.wiley.com/journal/117983344/home

Study details: British Journal of Dermatology, DOI 10.1111/j.1365-2133.2008.08872.x, The a-melanocyte stimulating hormone-related tripeptide K(D)PT stimulates human hair follicle pigmentation in situ under proinflammatory conditions; K.C. Meyer*; T. Brzoska ²,³; C. Abels² and R. Paus*§

*Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany

²Wolff Arzneimittel, Bielefeld, Germany

³Department of Dermatology, University of Münster, Münster, Germany

§School of Translational Medicine, University of Manchester, Manchester, U.K.

The British Association of Dermatologists is the central association of practising UK dermatologists. Our aim is to continually improve the treatment and understanding of skin disease.

For further information contact:

Nina Goad

British Association of Dermatologists

Communications Manager

Tel: 0207 391 6355

Email: nina@bad.org.uk

Website: www.bad.org.uk

Or Aeron Haworth

Media Officer

Faculty of Medical and Human Sciences

The University of Manchester

Tel: 0161 275 8383

Email: aeron.haworth@manchester.ac.uk

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#2

its very helpful for ppl like us, who lack hair.


#3

At least our remaining hair will have Colour


#4

» At least our remaining hair will have Colour

so you will look like a fancy young norwood 7? :slight_smile: No thanks.


#5

We need first our hair back to change the colour:-D


#6

If nothing works, and I must have thin hair the rest of my life, I want gray hair, not black.

Gray hair doesn’t look so weird as dark hair when it’s thin.


#7

» If nothing works, and I must have thin hair the rest of my life, I want
» gray hair, not black.
»
» Gray hair doesn’t look so weird as dark hair when it’s thin.

It is an interesting read and i dont think there is anything wrong with posting it up here! If a method was found to regorw hair but it lacked pigment or whatever then this could be adapted to help with that!


#8

» » If nothing works, and I must have thin hair the rest of my life, I want
» » gray hair, not black.
» »
» » Gray hair doesn’t look so weird as dark hair when it’s thin.
»
»
» It is an interesting read and i dont think there is anything wrong with
» posting it up here! If a method was found to regorw hair but it lacked
» pigment or whatever then this could be adapted to help with that!

Also it beats having to read all the bitchy comments going on in here at the moment! Anyone else sick of it?


#9

Anybody who thinks hair greying is as traumatic as actual hair loss has obviously never lost much hair.

There are millions of balding guys like us in their 20s-40s who would probably KILL just to have hair back even if it’s umpigmented.


#10

» Anybody who thinks hair greying is as traumatic as actual hair loss has
» obviously never lost much hair.
»
» There are millions of balding guys like us in their 20s-40s who would
» probably KILL just to have hair back even if it’s umpigmented.

absolutely, i am one of them!:wink:


#11

» » Anybody who thinks hair greying is as traumatic as actual hair loss has
» » obviously never lost much hair.
» »
» » There are millions of balding guys like us in their 20s-40s who would
» » probably KILL just to have hair back even if it’s umpigmented.
»
» absolutely, i am one of them!;-

Sad but true. It is time for a solution!


#12

» Anybody who thinks hair greying is as traumatic as actual hair loss has
» obviously never lost much hair.
»
» There are millions of balding guys like us in their 20s-40s who would
» probably KILL just to have hair back even if it’s umpigmented.

Spot on.


#13

» » Anybody who thinks hair greying is as traumatic as actual hair loss has
» » obviously never lost much hair.
» »
» » There are millions of balding guys like us in their 20s-40s who would
» » probably KILL just to have hair back even if it’s umpigmented.
»
» Spot on.

There are also millions of non balding guys who would probably kill to have their original hair color back.


#14

Well, then I guess they’re easily swayed to commit murder.

Dying your grey hairs colored again is a small problem compared to MPB.


#15

» Well, then I guess they’re easily swayed to commit murder.
»
» Dying your grey hairs colored again is a small problem compared to MPB.

Indeed. Show me one product that will give us back our hair that:
a) costs under 20 bucks and
b) only needs to be applied ONCE every 6 or so weeks

Last time I checked, every damn store sells easy-to-use and cheap hair color products while we’re still arguing, like kids, trying to repurpose everything including the kitchen sink to grow back a single follicle on our noggins.


#16

This post is only informative, I do not pretend to decrease the importance of hair loss. But for sure there is someone with grey hair who thinks that he should exchange some hair for colour, there is all kind of opinions. Also for sure there is someone who will exchange hair for a penis enlargement, I do not really mind.

Under my opinion this is a research forum and any advance should be wellcome.


#17

» This post is only informative, I do not pretend to decrease the importance
» of hair loss. But for sure there is someone with grey hair who thinks that
» he should exchange some hair for colour, there is all kind of opinions.
» Also for sure there is someone who will exchange hair for a penis
» enlargement, I do not really mind.
»
» Under my opinion this is a research forum and any advance should be
» wellcome.

Damn straight!


#18

I’m sorry if my posts came off as being critical for posting this article.

I was just reacting to some of the the sentences within the article. The author was saying that loss of hair color can be virtually as traumatic as hair loss itself. My frustration was directed at the article’s author.

I don’t wish to see this kind of information/articles kept off this forum as a whole. It’s a valid subject that may indeed have a relevance to us eventually.


#19

Ok a missunderstanding :slight_smile:

» I’m sorry if my posts came off as being critical for posting this article.
»
»
» I was just reacting to some of the the sentences within the article. The
» author was saying that loss of hair color can be virtually as traumatic as
» hair loss itself. My frustration was directed at the article’s author.
»
»
»
» I don’t wish to see this kind of information/articles kept off this forum
» as a whole. It’s a valid subject that may indeed have a relevance to us
» eventually.