A new gene called dickkopf 1 (DKK-1)has been found to cause DHT driven balding. Its levels are found to be increased in persons with bald scalp.
In vitro studies have shown that neutralizing this gene reverses DHT-induced epithelial cell death in cultured hair follicles.
Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes.
J Invest Dermatol. 2008 Feb;128(2):262-9