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MPB research: Black tea reduces DHT 72%, Propecia 70%


#1

Note: These folks are trumpeting the same mouse study I was talking about a while back. They seem to be in favor of taking black tea theaflavins in the form of a supplement. I dont know how long theaflavins from black tea are “bioactive” in the body. The mice in this study were given only black tea to drink as their sole beverage, so when the little creatures were thirsty, they had to drink black tea (or green tea or soy-infused liquids, et cetera). Therefore, the mice were getting tea probably at least every four or five hours while awake. Is a theaflavin supplement going to last long enough with one pill a day to inhibit alpha five reductase for 24 full hours, or would it have to be taken 2-3 times a day? I dont know, and without human testing, we never will either. That caveat aside, here is the link and Ive pasted the article from MPB research (I get this in my email even though I didn’t ask for it):

http://www.hairloss-research.org/LinkUp … a7-09.html
Propecia Reduces DHT by 71% Black Tea Reduces DHT by 72%

Black Tea consumption, according to this study done on mice at Harvard University lowered DHT levels by 72% and raised testosterone by 35%. Finasteride, (Propecia/Proscar) reduces DHT levels in both male humans and rats by 70%.

Nutrition and Cancer

Soy Phytochemicals and Tea Bioactive Components Synergistically Inhibit Androgen-Sensitive Human Prostate Tumors in Mice

Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

ABSTRACT

Although high doses of single bioactive agents may have potent anticancer effects, the chemopreventive properties of the Asian diet may result from interactions among several components that potentiate the activities of any single constituent. In Asia, where intake of soy products and tea consumption are very high, aggressive prostate cancer is significantly less prevalent in Asian men. The objective of the present study was to identify possible synergistic effects between soy and tea components on prostate tumor progression in a mouse model of orthotopic androgen-sensitive human prostate cancer. Soy phytochemical concentrate (SPC), black tea and green tea were compared with respect to tumorigenicity rate, primary tumor growth, tumor proliferation index and microvessel density, serum androgen level and metastases to lymph nodes. SPC, black tea and green tea significantly reduced tumorigenicity. SPC and black tea also significantly reduced final tumor weights. Green tea did not reduce final tumor weight, although it tended to elevate (P = 0.14) the serum dihydrotestosterone (DHT) concentration. The combination of SPC and black tea synergistically inhibited prostate tumorigenicity, final tumor weight and metastases to lymph nodes in vivo. The combination of SPC and green tea synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo. Inhibition of tumor progression was associated with reduced tumor cell proliferation and tumor angiogenesis. This study suggests that further research is warranted to study the role of soy and tea combination as effective nutritional regimens in prostate cancer prevention.

Although the DHT lowering effect of Black Tea `was not mentioned in the abstract, we obtained and reviewed the entire study including this revealing snippet:

Combined effects of soy phytochemicals and tea on serum testosterone and DHT concentrations.

“Mice treated with black tea (via standard,steeped beverage)tended to have a greater serum testosterone concentration (34.4%, P = 0.50) and had a 72% lower DHT concentration than controls (P < 0.05), suggesting that black tea may contain components that inhibit the activity of 5 -reductase, an enzyme that converts testosterone to the more bioactive DHT.”

This study also showed that the consumption of Green Tea as a beverage combined with Soy Isoflavone Concentrate significantly reduced DHT levels, and to some degree testosterone. Curiously it was found that the singular consumption of Green Tea raised both testosterone and DHT levels.

The implications of potential benefits to humans with Androgenetic Alopecia are significant.

It would appear reasonable based upon these findings that exclusive consumption of Black Tea or Black Tea Extract (Theaflavins) would likely reduce serum DHT to the same level as Propecia, and that the concurrent consumption of Soy Isoflavones or Soy Isoflavones with Green Tea would produce an additive effect.

Human studies done thus far on Soy and its’ effects on reproductive hormones in men in males indicate no apparent negative effect. It has also been established that Green Tea to some degree, suppresses androgen receptor signaling and inhibits both 5 alpha reductase isozymes. Green Tea and Grape Seed Extracts have been successfully combined with Taurine by L’Oreal to stop hair loss and promote hair growth. Based on this study however, some may feel that Green Tea should only be consumed with Soy. Given Green Tea’s multitude of anti-androgenic actions and the increase in SHBG (low levels of SHBG are associated with male pattern hair loss) that Green tea consumption causes, it is our position that Green Tea, even if singularly consumed, will likely benefit those with hair loss.

It is well established that the incidence of male and female pattern balding in the rural Orient is a small fraction of what it is here in the United States, and that the incidence of Androgenetic Alopecia among Asians who live in the U.S. is much higher than those living in the Orient. Soy based foods, a dietary staple, and the regular beverage consumption of Green and Black Teas factor significantly, and are perhaps causative, in this phenomenon.

The sexual side effects, including oft occurring Gynocomastia,(male breast enlargement), and the more ominous potential neurological side effects associated with finasteride (Propecia/Proscar), uncovered in the last few years, seem to make it less of a viable option. This compelling in vivo study provides direct evidence that blood levels of DHT can be reduced to a level equivalent to that of Propecia, in a natural, healthy, more cost effective way.

Exclusive consumption of strongly brewed Black Tea, as done by rats in this study to obtain a decrease in DHT and increase in Testosterone would not be practical for humans. Black Tea Extracts (Theaflavins) are available and contain Black Tea constituents at concentrations well above what would be obtainable via oral consumption.

Theaflavin Standardized Extract

An increasing number of scientists recognize the critical need to protect the arterial wall against low-density lipoprotein (LDL) oxidation and inflammatory insults. Research has shown that unique extracts present in black tea called theaflavins can have multiple applications for arterial health.

Theaflavin Standardized Extract contains a number of beneficial flavonoids found naturally in tea leaves that help support levels of cholesterol that are already within the normal range.

Theaflavins have been shown in human studies to protect against LDL oxidation and favorably affect endothelial function, thus helping to maintain healthy circulation.

Scientists have also found that black tea flavonoids possess strong antioxidant properties, which can help mitigate oxidative damage to cells and tissues from free radicals. In addition, theaflavins have been found to be helpful in down-regulating key inflammatory mediators, (several of which factor significantly into hormone related hair loss) in the body, thus helping to preserve cellular integrity.


#2

:slight_smile: bump


#3

» :slight_smile: bump

More so than the DHT-reducing properties, I find the fact that black tea raises testosterone levels to be interesting.

I understand that nettles does (raise T) as well. And so do tocotrienols. I have had a lot more energy since taking them (tocotrienols). And my hair looks much better.


#4

Black tea also increased testosterone in male RATS in another experiment.

1: J Ethnopharmacol. 2008 Aug 13;118(3):373-7. Epub 2008 May 4. Links
Effect of black tea brew of Camellia sinensis on sexual competence of male rats.Ratnasooriya WD, Fernando TS.
Department of Zoology, University of Colombo, Colombo 03, Sri Lanka. wdr@zoology.cmb.ac.lk

AIM: In Sri Lankan traditional medicine black tea brew (BTB) of Camellia sinensis (L.) O. Kuntze (Theaceae) is claimed to have male sexual stimulant activity. As this claim is not scientifically tested and proven, this study was undertaken to evaluate the effects of BTB on male sexual competence. MATERIAL AND METHODS: Different doses of BTB made from Sri Lankan high grown dust grade no 1 tea (84, 167 and 501 mg/ml) or water were orally administered to separate groups of rats (n=9 per group) and 3h later their sexual behaviour were monitored (for 15 min) using receptive females. RESULTS: The overall results showed that BTB possesses marked aphrodisiac activity (in terms of prolongation of latency of ejaculation shortening of mount- and intromission latencies and elevation of serum testosterone level). The aphrodisiac action had a rapid onset and appears to be mediated via inhibition of anxiety and elevation of serum testosterone level. Further, this aphrodisiac action was not associated with impairment of other sexual parameters like libido, sexual motivation, sexual arousal, sexual vigour or penile erection. BTB was also nontoxic (in terms of overt signs, liver and renal toxicity). CONCLUSIONS: It is concluded that BTB can function as a quick acting, safe, oral aphrodisiac which may also be useful in certain forms of sexual inadequacies such as premature ejaculation and impaired libido and other sexual functions.
PMID: 18565706 [PubMed - in process]


#5

People in India drink a lot of Masala Tea which includes a lot of black tea in the recipe. Maybe that’s why they seem to hold onto their hair well. :slight_smile:


#6

» People in India drink a lot of Masala Tea which includes a lot of black tea
» in the recipe. Maybe that’s why they seem to hold onto their hair well. :slight_smile:

Perry,

Are you still taking green tea extract? I decided to drop it from my regimen; still drink the tea though. Love the stuff!


#7

I’ve been pretty much doing the same as you. I just think it’s more fun drinking green tea as opposed to taking a pill. I might order some more green tea pills since I’m going on a major buying spree this week though. I might try drinking the black tea too. If anything I’ll drink masala tea more which has black tea in it. Masala tea is tastes so good. There are so many Indian restaurants in my area.

I’ve also been thinking about trying the red clover and red macca to help lower dht. Hopefully the four together won’t give me any beta sis type side effects.


#8

FIGURE 1 Effects of soy phytochemicals and tea combinations on final tumor weight (A) and serum prostate-specific antigen levels (B) in Severe combined immune deficient (SCID) mice bearing LNCaP human prostate cancer cells. Values are means ± SEM, n = 14–16. Means without a common letter differ, P < 0.05.

As you will see by looking at this chart, http://jn.nutrition.org/cgi/content/full/133/2/516/F1, black tea behaved just as one would think that Propecia would act. Human prostate cancer cells in these mice shrank by about 60% when they were given black tea to drink as their sole beverage, and their PSA levels (Prostate Specific Antigen) levels plummeted also.
Their tumor weights shrinking, PSA levels down…their DHT levels down by over 70%, but their Testosterone levels up by 34%.
If it walks like a duck and quacks like a duck…

The only way that black tea isn’t effective for -US- if if mice have type 1 alpha five reductase in their prostates and not type two. Even if that is so, then it means dutasteride should have comparitively few side effects because populations have been drinking black tea for eons, and they are OK.


#9

» I’ve been pretty much doing the same as you. I just think it’s more fun
» drinking green tea as opposed to taking a pill. I might order some more
» green tea pills since I’m going on a major buying spree this week though. I
» might try drinking the black tea too. If anything I’ll drink masala tea
» more which has black tea in it. Masala tea is tastes so good. There are so
» many Indian restaurants in my area.
»
» I’ve also been thinking about trying the red clover and red macca to help
» lower dht. Hopefully the four together won’t give me any beta sis type side
» effects.

Man, I love Indian food!

Yeah, I thought taking the green tea extract was overkill, so I dropped it. And as I think back, I am not sure that it ever did much for my hair.

You got me interested in the Masala tea.


#10

I was reading about black tea today and found out green tea, black tea, and oolong tea all come from the same plant. It’s just black tea is fermented longer and has more health benefits.

Anyway, I’ve been drinking black tea this week. I like it. It has more caffeine than green tea, but less than coffee. About the same amount of caffeine as a coke, but I don’t feel all jittery when I drink it. I’ve also been drinking masala tea which has black tea in it. Some places will load it with sugar though so you have to be careful.


#11

Finding something to reduce levels of DHT is not exactly newsworthy. Nor is finding a “natural” method IMHO.

The only thing that matters is whether any of these natural methods offer any significant improvement over the side effects of the man-made drugs. Do they? This is what is most worth studying.


#12

» I was reading about black tea today and found out green tea, black tea, and
» oolong tea all come from the same plant. It’s just black tea is fermented
» longer and has more health benefits.
»
» Anyway, I’ve been drinking black tea this week. I like it. It has more
» caffeine than green tea, but less than coffee. About the same amount of
» caffeine as a coke, but I don’t feel all jittery when I drink it. I’ve also
» been drinking masala tea which has black tea in it. Some places will load
» it with sugar though so you have to be careful.

I used to drink a lot of black tea, but had to stop because the caffeine would make me a bit “jittery.” Also, I couldn’t drink it with out cream (or lemon) and sugar.

For the past ten years though, I have been drinking green tea daily, straight. I love it. It has a relaxing effect on me.

I wonder if I could drink black tea without the other things added.

Have you changed up your regimen :wink: .