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Male-pattern baldness susceptibility locus at 20p11


#1

Male-pattern baldness susceptibility locus at 20p11

Nat Genet. 2008 Nov;40(11):1282-4

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).


#2

Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.

Am J Hum Genet. 2008 Mar;82(3):737-43

Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.


#3

» Male-pattern baldness susceptibility locus at 20p11
»
» Nat Genet. 2008 Nov;40(11):1282-4
»
» We conducted a genome-wide association study for androgenic alopecia in
» 1,125 men and identified a newly associated locus at chromosome 20p11.22,
» confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x
» 10(-14) for rs1160312). The one man in seven who harbors risk alleles at
» both 20p11.22 and AR (encoding the androgen receptor) has a
» sevenfold-increased odds of androgenic alopecia
(OR = 7.12, P = 3.7 x
» 10(-15)).

that pretty much says it all


#4

» » Male-pattern baldness susceptibility locus at 20p11
» »
» » Nat Genet. 2008 Nov;40(11):1282-4
» »
» » We conducted a genome-wide association study for androgenic alopecia in
» » 1,125 men and identified a newly associated locus at chromosome
» 20p11.22,
» » confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x
» » 10(-14) for rs1160312). The one man in
» seven who harbors risk alleles at
» » both 20p11.22 and AR (encoding the androgen receptor) has a
» » sevenfold-increased odds of androgenic alopecia
(OR
» = 7.12, P = 3.7 x
» » 10(-15)).
»
»
»
» that pretty much says it all

Ok, this may help my grandson one day if we can correct the chromosome before he is born, but what about ME right here right now???


#5

» Ok, this may help my grandson one day if we can correct the chromosome
» before he is born, but what about ME right here right now???

HT


#6

» » Ok, this may help my grandson one day if we can correct the chromosome
» » before he is born, but what about ME right here right now???
»
» HT

So in the year 2312 the gene will be taken out of newborns…awesome!!!


#7

Susceptibility variants for male-pattern baldness on chromosome 20p11

Nat Genet. 2008 Nov;40(11):1279-81

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.