More info on the apple stem cells:
"In contrast to embryonic stem cells, adult stem cells persist for the whole life. They are indispensable to the maintenance and repair of tissues. Some few stem cells in the basal layer of the epidermis produce all the other keratinocytes that differentiate to the stratum corneum and are renewed every four weeks. In older skin, the epidermal stem cells are less active and lower in number leading to wrinkles and an increased renewal time of the epidermis. Plants too have stem cells. After isolation, they can be cultured in liquid media. PhytoCellTec™ Malus Domestica, a preparation of apple stem cells, was found to stimulate the proliferation of human blood stem cells and to increase the lifespan of skin fibroblast cells and of isolated hair follicles.
"Results and Discussions Protection of Human Stem Cells Stem cells from umbilical cord blood represent an ethically correct source of human stem cells. An extract of Uttwiler Spätlauber stem cells was tested on cell viability of umbilical cord blood stem cells in two different studies. First, the effect of the extract on the proliferative activity of the human stem cells was analyzed. There was a clear, concentration-dependent effect found (Fig. 4). At only 0.1%, the extract stimulated cell proliferation by 80%. In a second experiment, the stem cells were stressed through irradiation with UV light.
“Retardation of Senescence in Isolated Hair Follicles Human hair follicles can be isolated by microdissection from skin fragments that are left after facelift surgery. Only follicles in the anagen phase are collected. Hair follicles are mini organs that represent a natural coculture model of epidermal and melanocyte stem cells and differentiated cells. The follicles can be maintained in a growth medium where they elongate until about day 14. Then the follicle cells gradually become senescent or undergo apoptosis which is a programmed cell death. Because of the lack of blood circulation, isolated hair follicles cannot be kept alive and growing for a longer period. But isolated hair follicles are test models to screen for actives that can delay the necrosis process. Addition of 0.2% of an extract of Uttwiler Spätlauber stem cells was found to slightly but clearly postpone senescenceand apoptosis-induced necrosis. Figure 6 shows that follicles kept in presence of the Uttwiler Spätlauber stem cell extract continued to elongate until day 18, whereas the control follicles started to shrink after day 14.”