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Kotsarelis on BBC. Its global news now


#21

» » » Is this the case basically or they just realized that they were doing
» it
» » » wrong and they try to sugarcoat it?
» »
» »
» » Exactly.
»
» Oh, c’mon. You have absolutely no idea what you’re talking about. Maybe
» you’re just having a bad day - which is totally fine - but for goodness
» sake, at least try to understand the science before making useless and
» cynical comments such as this one.
»
» hey Shooter. the only question that i have is why someone (follica)will try through trials to develop something, while knowing that this technology before even to hit the market is already out-fashioned by something which works better & faster, To my eyes cream solution seems to be by far less primitive than the wounding process. I dont get the point. that’s it.

cheers.


#22

» » » » Is this the case basically or they just realized that they were
» doing
» » it
» » » » wrong and they try to sugarcoat it?
» » »
» » »
» » » Exactly.
» »
» » Oh, c’mon. You have absolutely no idea what you’re talking about. Maybe
» » you’re just having a bad day - which is totally fine - but for goodness
» » sake, at least try to understand the science before making useless and
» » cynical comments such as this one.
» »
» » hey Shooter. the only question that i have is why someone (follica)will
» try through trials to develop something, while knowing that this technology
» before even to hit the market is already out-fashioned by something which
» works better & faster, To my eyes cream solution seems to be by far less
» primitive than the wounding process. I dont get the point. that’s it.
»
» cheers.

I think your question has validity. Perhaps it is because Follica knows that, although a cream will be a superior solution long-term, wounding + a drug that is already available will be a superior solution near-term. If they can release their wounding protocol within a few years, they can use the revenue to invent a cream that will ultimately be more patient-friendly. It’s like the planned obsolescence that Apple uses on its electronics. Cheers to you as well.


#23

»
» First of all, Dr. G. Cotsarelis himself, did practically nothing for this
» study (just his name has been used for hyping). Secondly, the skin (biggest
» organ) couldn’t exist without specific types of “stem cells” in it
» and everywhere in it (which regenerates themself DAILY)!
»
» “Cots study” is, in fact, a study for amateurs or maybe something for
» students in their 1st biology semester. This is no joke!

I think there are a few reasons why they used Dr Cotsarelis in the press, first of all the Dr who did most of the work has left UPENN, but it was UPENN as a Universisty who were being funded to do the study so it makes sense they would speak to someone from there, and secondly Cotsarelis is the head of the deparment and is experienced with dealing with the media.

I don’t think it was hype, it was just common sense that he’d be the guy to go on camera.


#24

Why couldn’t you use an inert retrovirus to deliver the proper code? You could probably create an acquired tolerance within the body.


#25

» Why couldn’t you use an inert retrovirus to deliver the proper code? You
» could probably create an acquired tolerance within the body.

Because such a retrovirus is inert. (lol)


#26

» » » » Is this the case basically or they just realized that they were
» doing
» » it
» » » » wrong and they try to sugarcoat it?
» » »
» » »
» » » Exactly.
» » --------------------
» » Oh, c’mon. You have absolutely no idea what you’re talking about.
»
» Sorry shooter (you’re an appreciated user), but in this case, it is YOU who
» seems to have no idea.
»
» For instance:
» » Cotsarelis’s new findings conclusively prove that stem cells do exist in
» » ample amounts in bald scalps, …
»
» First of all, Dr. G. Cotsarelis himself, did practically nothing for this
» study (just his name has been used for hyping). Secondly, the skin (biggest
» organ) couldn’t exist without specific types of “stem cells” in it
» and everywhere in it (which regenerates themself DAILY)!
»
» “Cots study” is, in fact, a study for amateurs or maybe something for
» students in their 1st biology semester. This is no joke!

For your information it is common academic practice that the person in charge of supervision (such your supervision professor) is automatically credited for work - even if he is has absolutely nothing to do with… it may appear unfair to some but thats just simply the way things are done at universities… and its not even all that unfair…


#27

» Why couldn’t you use an inert retrovirus to deliver the proper code? You
» could probably create an acquired tolerance within the body.

that sounds extremely risky… as far as i know, modification of dna code via a retroviral vector is hardly a safe procedure… and i’m not even convinced they would know what to change.


#28

» For your information it is common academic practice that the person in
» charge of supervision (such your supervision professor) is automatically
» credited for work - even if he is has absolutely nothing to do with… it
» may appear unfair to some but thats just simply the way things are done at
» universities… and its not even all that unfair…

Your so-called “information” demonstrates just 1 reason, why we, in Austria, rarely (i.e. extremely unwilling) accept students from Germany neither at our universities, nor any graduates in our companies. In the past, until now - nothing has changed concerning that issue. And as already mentioned, you’re a typical example.


#29

» » For your information it is common academic practice that the
» person in
» » charge of supervision (such your supervision professor) is automatically
» » credited for work - even if he is has absolutely nothing to do with…
» it
» » may appear unfair to some but thats just simply the way things are done
» at
» » universities… and its not even all that unfair…
»
» Your so-called “information” demonstrates just 1 reason, why we, in
» Austria, rarely (i.e. extremely unwilling) accept students from
» Germany neither at our universities, nor any graduates in our companies. In
» the past, until now - nothing has changed concerning that issue. And as
» already mentioned, you’re a typical example.

I studied at UC Berkeley and wrote a paper on the bandgap of Indium Nitrite… my official supervisor was the chairman of the material science department and was co-authored eventho i had merely spoken o the man ONCE when i started out. He organized the funding and put the people in charge to enable me to do research… so obviously he is entitled to be on the publication. It’s not only common practice in germany its INTERNAL common practice - even in austria… if you had ever stepped foot in an academic entity you wld have known this.


#30

» » » For your information it is common academic practice that the
» » person in
» » » charge of supervision (such your supervision professor) is
» automatically
» » » credited for work - even if he is has absolutely nothing to do with…
» » it
» » » may appear unfair to some but thats just simply the way things are
» done
» » at
» » » universities… and its not even all that unfair…
» »
» » Your so-called “information” demonstrates just 1 reason, why we, in
» » Austria, rarely (i.e. extremely unwilling) accept students from
» » Germany neither at our universities, nor any graduates in our companies.
» In
» » the past, until now - nothing has changed concerning that issue. And as
» » already mentioned, you’re a typical example.
»
» I studied at UC Berkeley and wrote a paper on the bandgap of Indium
» Nitrite… my official supervisor was the chairman of the material science
» department and was co-authored eventho i had merely spoken o the man ONCE
» when i started out. He organized the funding and put the people in charge
» to enable me to do research… so obviously he is entitled to be on the
» publication. It’s not only common practice in germany its INTERNAL common
» practice - even in austria… if you had ever stepped foot in an academic
» entity you wld have known this.

INTERNATIONAL

Hairsite: remove the 2 minute editing ban!??!?


#31

» I studied at UC Berkeley and wrote a paper on the bandgap of Indium
» Nitrite… my official supervisor was the chairman of the material science
» department and was co-authored eventho i had merely spoken o the man ONCE
» when i started out. He organized the funding and put the people in charge
» to enable me to do research… so obviously he is entitled to be on the
» publication. It’s not only common practice in germany its INTERNAL common
» practice - even in austria… if you had ever stepped foot in an academic
» entity you wld have known this.

No, I’m just the one who is (partly) responsible for not accepting such “individuals” like you neither at our universities, nor in our industry. And your 2nd post just demonstrates one more reason, why we do so.


#32

» » I studied at UC Berkeley and wrote a paper on the bandgap of Indium
» » Nitrite… my official supervisor was the chairman of the material
» science
» » department and was co-authored eventho i had merely spoken o the man
» ONCE
» » when i started out. He organized the funding and put the people in
» charge
» » to enable me to do research… so obviously he is entitled to be on the
» » publication. It’s not only common practice in germany its INTERNAL
» common
» » practice - even in austria… if you had ever stepped foot in an
» academic
» » entity you wld have known this.
»
» No, I’m just the one who is (partly) responsible for not accepting such
» “individuals” like you neither at our universities, nor in our industry.
» And your 2nd post just demonstrates one more reason, why we do so.

you are completely delusional if u think austrian universities are any different.


#33

I don’t understand why it takes 10 years to develop a cream that can deliver the progenitor cells, surely Aderans or Follica would come up with something by then


#34

» I don’t understand why it takes 10 years to develop a cream that can
» deliver the progenitor cells, surely Aderans or Follica would come up with
» something by then

its not about developing a cream that delivers cells. its about a cream that activates the existing stem cells to produce progenitor cells. For this u have to figure out which cell signals are required to make the stem cells turn into progenitor cells and then produce a cream which artificially creates that sort of a cell environment.

perhaps it can be figured out through chemical compound comparison of a “healthy” scalp and a hairless scalp to see whats missing… its most likely not a trivial task… thus the 10 years of research.


#35

» » I don’t understand why it takes 10 years to develop a cream that can
» » deliver the progenitor cells, surely Aderans or Follica would come up
» with
» » something by then
»
» its not about developing a cream that delivers cells. its about a cream
» that activates the existing stem cells to produce progenitor cells. For
» this u have to figure out which cell signals are required to make the stem
» cells turn into progenitor cells and then produce a cream which
» artificially creates that sort of a cell environment.
»
» perhaps it can be figured out through chemical compound comparison of a
» “healthy” scalp and a hairless scalp to see whats missing… its most likely
» not a trivial task… thus the 10 years of research.

But this 10-year talk is hogwash. They are saying it will take 10 years to determine which compounds are needed and get those compounds into the marketplace in the form of a cream but that is total nonesense. These people are not factoring in recent events such as the ongoing research with Acell and Histogen. Both Acell and Histogen can make the scalp skin environment the same as it was when the scalp skin was younger and properly producing these progenitor cells. That is the point to Acell’s hair loss reseach and it is also the point to Histogen’s hair growth treatment. Acell and Histogen do exactly what this new study says it will take 10 years to do. Acell’s and Histogen’s hair loss treatments are very similar to what we are being told it will take 10 years to bring to market.


#36

» » » I don’t understand why it takes 10 years to develop a cream that can
» » » deliver the progenitor cells, surely Aderans or Follica would come up
» » with
» » » something by then
» »
» » its not about developing a cream that delivers cells. its about a cream
» » that activates the existing stem cells to produce progenitor cells. For
» » this u have to figure out which cell signals are required to make the
» stem
» » cells turn into progenitor cells and then produce a cream which
» » artificially creates that sort of a cell environment.
» »
» » perhaps it can be figured out through chemical compound comparison of a
» » “healthy” scalp and a hairless scalp to see whats missing… its most
» likely
» » not a trivial task… thus the 10 years of research.
»
»
» But this 10-year talk is hogwash. They are saying it will take 10 years to
» determine which compounds are needed and get those compounds into the
» marketplace in the form of a cream but that is total nonesense. These
» people are not factoring in recent events such as the ongoing research with
» Acell and Histogen. Both Acell and Histogen can make the scalp skin
» environment the same as it was when the scalp skin was younger and properly
» producing these progenitor cells. That is the point to Acell’s hair loss
» reseach and it is also the point to Histogen’s hair growth treatment.
» Acell and Histogen do exactly what this new study says it will take 10
» years to do. Acell’s and Histogen’s hair loss treatments are very similar
» to what we are being told it will take 10 years to bring to market.

I dont Agree that Acell is making “the scalp skin environment the same as it was when the scalp skin was younger”. Acell is culturing the resistant cells (from the donor area) and implanting them to the recipient site, they are not applying a chemical compound to induce signaling for the existing stem cells to form progenitor cells. They are basically generating new DHT resistant follicles not reviving the existing ones.

What Histogen is doing is kind of in the dark… as no one seems to know exactly which compound they are using… perhaps they have figured out that certain substances are doing exactly what this discovery is speaking about… apparently the compound they are using is reviving existing follicles and therefore must be inducing progenitor cell growth…


#37

» » » » I don’t understand why it takes 10 years to develop a cream that can
» » » » deliver the progenitor cells, surely Aderans or Follica would come
» up
» » » with
» » » » something by then
» » »
» » » its not about developing a cream that delivers cells. its about a
» cream
» » » that activates the existing stem cells to produce progenitor cells.
» For
» » » this u have to figure out which cell signals are required to make the
» » stem
» » » cells turn into progenitor cells and then produce a cream which
» » » artificially creates that sort of a cell environment.
» » »
» » » perhaps it can be figured out through chemical compound comparison of
» a
» » » “healthy” scalp and a hairless scalp to see whats missing… its most
» » likely
» » » not a trivial task… thus the 10 years of research.
» »
» »
» » But this 10-year talk is hogwash. They are saying it will take 10 years
» to
» » determine which compounds are needed and get those compounds into the
» » marketplace in the form of a cream but that is total nonesense. These
» » people are not factoring in recent events such as the ongoing research
» with
» » Acell and Histogen. Both Acell and Histogen can make the scalp skin
» » environment the same as it was when the scalp skin was younger and
» properly
» » producing these progenitor cells. That is the point to Acell’s hair
» loss
» » reseach and it is also the point to Histogen’s hair growth treatment.
» » Acell and Histogen do exactly what this new study says it will take 10
» » years to do. Acell’s and Histogen’s hair loss treatments are very
» similar
» » to what we are being told it will take 10 years to bring to market.
»
» I dont Agree that Acell is making “the scalp skin environment the same as
» it was when the scalp skin was younger”. Acell is culturing the resistant
» cells (from the donor area) and implanting them to the recipient site, they
» are not applying a chemical compound to induce signaling for the existing
» stem cells to form progenitor cells. They are basically generating new DHT
» resistant follicles not reviving the existing ones.
»
» What Histogen is doing is kind of in the dark… as no one seems to know
» exactly which compound they are using… perhaps they have figured out that
» certain substances are doing exactly what this discovery is speaking
» about… apparently the compound they are using is reviving existing
» follicles and therefore must be inducing progenitor cell growth…

It’s my understanding that Acell’s compound also grows limbs in animals, and has grown a thumb or two for humans, and that has nothing to do with dht-resistant cells. It’s my understanding that Acell involves a compound that is regenerative due to its’ growth factors. That is what I believe Dr. Roberts in Canada experimented with on a human patient. It has NOT been my understanding that the hair reseach involving Acell only involves dht-resistant cells, but rather I have been under the impression that the Acell hair growth research involves a regerative compound that contains growth factors designed to make healing better by applying the growth factors needed to make the healing area more as it should be and loaded with these growth factors.

It is also my understanding that Histogen uses growth factors to make the environment more like it was when the person was younger and the environment was at its’ healthiest.


#38

I think the more we go into this the more it sounds like science fiction. At least if it was the stemcells which we know how to harvest and they are basically more simple than progenitor cells we could have something sooner.Almost everyone even now offers stemcell treatments.

These progenitor cells sounds much more difficult because they are more advanced cells something between a stem cell and a fully differentiated cell.

this wounding and the growth factors seems to hoax them into activation but we dont even know how many times this has to be repeated or if it works consistently enough.

I basically think we are back to 0 with this finding. Or to put it better i think we basically have a starting point which we didnt have all these years. through trial and error and a bit of luck they basically understand a bit more about the problem.

Activating these progenitor cells its a whole new ball game. I think we are in for a long run…


#39

» I think the more we go into this the more it sounds like science fiction.
» At least if it was the stemcells which we know how to harvest and they are
» basically more simple than progenitor cells we could have something
» sooner.Almost everyone even now offers stemcell treatments.
»
»
» These progenitor cells sounds much more difficult because they are more
» advanced cells something between a stem cell and a fully differentiated
» cell.
»
»
» this wounding and the growth factors seems to hoax them into activation but
» we dont even know how many times this has to be repeated or if it works
» consistently enough.
»
» I basically think we are back to 0 with this finding. Or to put it better i
» think we basically have a starting point which we didnt have all these
» years. through trial and error and a bit of luck they basically understand
» a bit more about the problem.
»
» Activating these progenitor cells its a whole new ball game. I think we are
» in for a long run…

I think Histogen is the answer if the results are compoundable… I think their mixture of growth factors is what is waking them up… Until then maintain or Acell/PRP transplants.


#40

I’ve seen non-cancerous tumours cut out of people (large ones) and some have hair and even teeth forming on them.

It indicates that hair formation is indeed possible. Just got to figure out HOW! First guy to figure out a method and market it will be richer than Bill Gates easily.