[quote][postedby]Originally Posted by roger_that[/postedby]
Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds’ chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist.
[postedby]Originally Posted by jarjarbinx[/postedby]
I don’t think you can get a pharmacist in the civilized world to do this.
Also, when I said that science first needs to find out what dose produces the desired effect what I meant was that scientists would use a piece of detached human skin or human skin grafted to mice and apply the topicalized (liquid) version of the drug to it. The scientists would be looking to see what dose effectively blocks the enzymes they’re trying to block, and they would be watching what effect doing so has on the human follicles inside the skin. This would involve biopsies and stuff like that. I’m talking about pre-clinical basic science.
I don’t think you’re going to get a pharmacist in the civilized world to do what you’re suggesting until more basic science is performed with this treatment concept.[/quote]
Jarjar – I understand what you’re saying. This was just a suggestion for a “quick and dirty” approach to getting this stuff tested as soon as possible, even if the testing is somewhat risky and may not yield results as accurate and reliable as we want. It seems you’re always looking ways we can get things done fast, with minimal waiting and expense, so I just thought I’d throw the idea out there as a suggestion. I totally agree that few pharmacists in the “civilized world” might want to do this, but these days you never know. We could even get someone in Russia, Eastern Europe, China, etc., where people are much less worried about lawsuits, but places that still have some well-trained lab scientists and pharmacists/pharmacologists. Just an idea.
As for your suggestion, yes, I realize that would be the way to go, but again, waiting for someone to do in vitro skin testing, biopsies, etc., will take a long time. I assume Dr. Christiano’s on this, but who knows how long it’ll be before she publicly comes out with some results? 6 months? A year? Who knows? It’s not likely to be very soon, though. She’ll have to get funding squared away, and will likely only announce results in a formal journal article, which will take many months if not more than a year to complete.