Interesting study

Stem cell; cell based hair therapy
21

I’m still not sure if they’re trying the Acell+PRP mix as a stand alone treatment, I think it should be the first thing to test, not in conjuction with transplants which is what it looks like they’re doing. If the Acell+PRP mix works to a certain extent without transplants, we then need to see if it’s compoundable, if it is we shouldn’t need to have any transplants.

They’re probably never gonna test anything that might put them outta work no matter how feasible it might appear. They aren’t in the business of doing whatever it takes to fix our baldness problems. They are in the business of selling us their surgical skills.

Although for the record I am not optimistic that just PRP+Acell would work anyway.

22

Follica Co-Founder and Team Find New Clues About Male Baldness
Ryan McBride 1/4/11

Hold on to your toupees. Scientists have spotted a trend in scalp samples from men with pattern baldness that could lead to a new way to treat hair-loss. The discovery hits close to home for Follica, a startup focused on hair-loss treatments, whose scientific co-founder was one of the main researchers behind the new findings.

The new research found that men with pattern baldness have plenty of hair follicle stem cells in their scalps. This might mean that the stem cells, important to hair follicle development, need to be activated in some way to treat baldness. George Cotsarelis, a dermatologist from the University of Pennsylvania and co-founder of Follica, co-authored a paper on the research released today from the Journal of Clinical Investigation. Follica itself did not participate in the research.

Follica CEO William Ju says that the findings in the paper are in line with the rationale for the company’s experimental device and drug treatment for baldness. The mostly virtual biotech firm, which was hatched and incubated at PureTech Ventures in Boston, has been developing a treatment for pattern baldness that stimulates the re-growth of hair follicles by harnessing a natural wound-healing response.

“Our hypothesis has always been that we could harness adult stem cells to grow new hair follicles,” Ju says. “I think what this recent paper shows is that the stem cells are indeed present.”

Cotsarelis agrees. He says that the findings of the research make a treatment to re-grow hair follicles even more plausible than before. Follica is trying to regenerate hair follicles anew, he says, and he and his colleagues show in the study that the hair follicle stem cells are already present in the scalp.

“It made us realize that male pattern baldness is probably not a stem cell problem as far as numbers go, but that it’s more or a problem of activation of the stem cells,” Cotsarelis says.

In fact, the study’s human scalp samples—collected from men with pattern baldness who were undergoing hair transplantations—lacked progenitor cells that help grow new shafts of hair. Those progenitor cells develop from stem cells. So some of the answers about the causes of male baldness might lie in understanding why the stem cells present in guys’ hair-deprived scalps don’t advance to the progenitor stage. The study found no significant difference in the amount of stem cells between scalp samples from haired and balding regions from the same people. Cotsarelis says that further research is needed to understand why this is.

An overseas human clinical study of Follica’s drug-device combo treatment for baldness is under way, Ju says. He declined to share key specifics of the ongoing study, such as where exactly it is taking place, yet he did say that the firm eventually plans to pursue approval of the treatment in the U.S.

“I will say that the trial is being done in a very quality fashion outside the United States,” Ju says. “They are being done under the same standards as one would see in the United States under FDA [oversight].”

Unfortunately, Ju wouldn’t provide a timeline for when a clinical trial of the firm’s treatment might open to those seeking to remedy their baldness in the U.S. But based on the avalanche of comments we typically get on our stories about the startup, it probably won’t have any trouble finding participants when and if it launches a study in this country.

THANKS to @rev and Mr. R. McBride (xconomy’s correspondent) & Mr. R. Buderi (xconomy’s founder) !

Article-related study:
http://www.jci.org/articles/view/44478

Study-related article:

23

» » »
» » » Thanks for the information, much appreciated.
» » »
» » » It would be fantastic if the PRP/Acell combination works
» » well. I’m ready
» » » to do something, but, won’t jump in on this until i see conclusive
» » » documentation that it works better than just PRP alone. Hopefully
» will
» » » know that within a year’s time.
» »
» » I’m still not sure if they’re trying the Acell+PRP mix as a
» stand alone
» » treatment, …
»
» I could give you ‘groundbreaking’ answers (fully scientifically supported)
» concerning your questions/thoughts, but if I would, this could knock off
» the socks from some hair scientists - and especially the ones from some HT
» doctors (the ones, who actually do not know what they do since years) …
»
»
» But some guys here say I’m an asshole. So, why should I disappoint them?
» :slight_smile:

you ARE an asshole… and even worse… your starting to sound like rev or was it roger_that? Someone who announced HUGE groundbreaking news… whats the point of saying I know something but wont tell you… you think you’re making us jealous/curious whatever? frankly u pretend u know everything about hair loss… even using phrases like “i know its hard for you (laymen) to understand”… kinda pretending you are a hairloss scientist :smiley: i’m sure you just like the rest of us have no insight in cell biology or anything… its just we at least dno’t pretend that we do.

24

» you ARE an asshole… and even worse… your starting to sound like rev or
» was it roger_that?

So what? rev or roger_that? That means, you do not even know who said what or who did what, and simply use the usernames of users (and thereby discredit them), who have absolutly nothing to do with one or the other.

So, you think it make sense to discuss with EXTEMELY useless users like you in detail about ‘things’ like cytokeratin 19 or how about cytokerin 14? Or about Bcl-2 proteins or Bax factors or about “CD200-rich and CD34-positive hair follicle progenitor cells”? Or why not about all the known 20 different cell types (besides many undiscovered cell types) in a hair follicle in general, or about what exactly finally promotes apoptosis and how can I avoid apoptosis? - and so on and so forth …

» you just like the rest of us have no insight in cell biology or anything…

Does that mean that you think that every HS user & reader is stupid?

You claim you have ‘master degree’ in physics? Ok. You have 5 minutes to provide a solution for the following extremely EASY question for masters:

There are chickens & rabbits in stable/stall. All in all there are 52 legs and 19 heads.
But how many, in fact, there are 1) chickens and 2) rabbits in the stable?

Show me your results, master. lol

» you ARE an asshole… and even worse… your starting to sound like rev or
» was it roger_that?

@HairSite - I thought you have ‘strict’ rules? :expressionless:

25

» » you ARE an asshole… and even worse… your starting to sound like
» rev or
» » was it roger_that?
»
» So what? rev or roger_that? That means, you do not even know who said what
» or who did what, and simply use the usernames of users (and thereby
» discredit them), who have absolutly nothing to do with one or the other.
»
» So, you think it make sense to discuss with EXTEMELY useless users like
» you in detail about ‘things’ like cytokeratin 19 or how about cytokerin
» 14? Or about Bcl-2 proteins or Bax factors or about “CD200-rich and
» CD34-positive hair follicle progenitor cells”? Or why not about all the
» known 20 different cell types (besides many undiscovered cell types) in a
» hair follicle in general, or about what exactly finally promotes apoptosis
» and how can I avoid apoptosis? - and so on and so forth …
»
» » you just like the rest of us have no insight in cell biology or
» anything…
»
» Does that mean that you think that every HS user & reader is stupid?
»
» You claim you have ‘master degree’ in physics? Ok. You have 5 minutes to
» provide a solution for the following extremely EASY question for masters:
»
» There are chickens & rabbits in stable/stall. All in all
» there are 52 legs and 19 heads.
» But how many, in fact, there are 1) chickens and 2) rabbits in the
» stable?
»
» Show me your results, master. lol
» -----------------------------
»
» » you ARE an asshole… and even worse… your starting to sound like
» rev or
» » was it roger_that?
»
» @HairSite - I thought you have ‘strict’ rules? :expressionless:

I would like you to explain Iron Man… Is there something that we don’t know about the capabilities of Acell/PRP/Growth Factors?

26

» I would like you to explain Iron Man… Is there something that we don’t
» know about the capabilities of Acell/PRP/Growth Factors?

My answer is - no! That means, IF you CAREFULLY (study) read all (my and others) recent posts/threads/topics - for instance …

http://www.hairsite.com/hair-loss/board_entry-id-76587-page-0-category-1-order-last_answer-descasc-DESC.html

… many answers ARE already there! So it just needs “a written form/brief summary/conclusion/discussion/suggestions for possible protocols”, based on ALL the gathered infos we/you already (finally) have. So WHO has the skills (as well as knowledge) to do this (to write such papers/posts)? hairman2??

27

Well I have to admit it is pretty nice to know that I have all the hair “cells” in my scalp. They are still there from 10-15 years ago, they haven’t gone anywhere.

They just need the proper kickstart.

It is a little frustrating that it took them this long to figure this out … I don’t really see why they couldn’t have more carefully compared balding and non-balding scalp and figured this out 5 or even 10 years ago.

Oh well.

Maybe Acell (or Histogen) jump start something related to these malfunctioning stem cells, because if “Acell-ed grafts” are causing 2-3 additional surrounding hairs to also pop up in the balding area … perhaps the Acell is signaling something to the surrounding “sleeping” follicles.

28

» Well I have to admit it is pretty nice to know that I have all the hair
» “cells” in my scalp. They are still there from 10-15 years ago, they
» haven’t gone anywhere.
»
» They just need the proper kickstart.
»
» It is a little frustrating that it took them this long to figure this out
» … I don’t really see why they couldn’t have more carefully compared
» balding and non-balding scalp and figured this out 5 or even 10 years ago.
»
»
» Oh well.
»
» Maybe Acell (or Histogen) jump start something related to these
» malfunctioning stem cells, because if “Acell-ed grafts” are causing 2-3
» additional surrounding hairs to also pop up in the balding area … perhaps
» the Acell is signaling something to the surrounding “sleeping” follicles.

Everything you say is ‘technically’ fully correct.

29

»
» There are chickens & rabbits in stable/stall. All in all
» there are 52 legs and 19 heads.
» But how many, in fact, there are 1) chickens and 2) rabbits in the
» stable?
»
» Show me your results, master. lol
» -----------------------------
»

I know! I know, Teacher! Yes, I know!
There are seven rabbits and twelve chickens in the stall!
(while you read it imagine the speech of Martin Prince
from “The Simpsons” )

30

» »
» » There are chickens & rabbits in stable/stall. All in all
» » there are 52 legs and 19 heads.
» » But how many, in fact, there are 1) chickens and 2) rabbits in
» the
» » stable?
» »
» » Show me your results, master. lol
» » -----------------------------
» »
»
» I know! I know, Teacher! Yes, I know!
» There are seven rabbits and twelve chickens in the stall!

:ok:

31

» » you ARE an asshole… and even worse… your starting to sound like
» rev or
» » was it roger_that?
»
» So what? rev or roger_that? That means, you do not even know who said what
» or who did what, and simply use the usernames of users (and thereby
» discredit them), who have absolutly nothing to do with one or the other.

LOL sorry but contrary to you I have a LIFE… and wldnt even dream of spending time finding the original post to make a screenshot and paste it here like you wld because you are obviously unemployed. If i hurt someones feeling by discrediting them… i cldnt care less. They’ll just have to deal with it.

» So, you think it make sense to discuss with EXTEMELY useless users like
» you in detail about ‘things’ like cytokeratin 19 or how about cytokerin
» 14? Or about Bcl-2 proteins or Bax factors or about “CD200-rich and
» CD34-positive hair follicle progenitor cells”? Or why not about all the
» known 20 different cell types (besides many undiscovered cell types) in a
» hair follicle in general, or about what exactly finally promotes apoptosis
» and how can I avoid apoptosis? - and so on and so forth …

lol sorry to say but throwing around random words you’ve probably cut and pasted from somewhere doesnt make you a scientist…

» » you just like the rest of us have no insight in cell biology or
» anything…
»
» Does that mean that you think that every HS user & reader is stupid?

pretty much yea… there seem to be very few experts on this topic world wide… and precisely NONE in this forum.

» You claim you have ‘master degree’ in physics? Ok. You have 5 minutes to
» provide a solution for the following extremely EASY question for masters:
»
» There are chickens & rabbits in stable/stall. All in all
» there are 52 legs and 19 heads.
» But how many, in fact, there are 1) chickens and 2) rabbits in the
» stable?

Altho this really doesn’t have anything to do with physics and it has already been answered… I’ll still go ahead and finish your high school homework.

Abbreviations used:

Rabbit = r
Chicken = c
Legs = l
Heads = h
x = number of rabbits
y = number of chicken

rabbits have 4 legs while chicken have 2:
r = 4l + 1h
c = 2l + 1h

Ansatz:
x r + y c = 52l + 19h

x(4l + 1h) + y(2l +1h) = 52l + 19h
x4l + xh + y2l + yh = 52l + 19h

l und h ausklammern:
(4x + 2y)l + (x + y)h = 52l + 19h

comparison:
I) 4x + 2y = 52
II) x + y = 19

from II):
x = 19 - y

II) in I):
4 (19 - y) + 2y = 52
76 - 4y + 2y = 52
-2y = -24
y = 12

in I)
x + 12 = 19
x = 7

Amount of rabbit x = 7, amount of chicken y = 12

test:
7 (4l + 1h) + 12 (2l +1h) = 28l + 7h + 24l + 12h = 52l + 19h

The more elegant way of solving this wld be to use the determinant of a matrix as these are all linear equations… but writing matrices in ASCII is no trivial matter… and i sure wasnt going to write this on paper and scan it for your entertainment.
However, i have to emphasize again how funny it is that you deem it so unbelievable that i have a german DIPLOM (not masters) in physics. Amazing how having such a fairly common degree seems to be so hard for you to believe. By doing so, you don’t exactly place yourself in the most flattering light. If doubts still remain i can send you my degree via email (including a verification link of the uni würzburg).

» Show me your results, master. lol
» -----------------------------
»
» » you ARE an asshole… and even worse… your starting to sound like
» rev or
» » was it roger_that?
»
» @HairSite - I thought you have ‘strict’ rules? :expressionless:

u’re the one who used the word “asshole” i was basically just quoting you on it

32

» » Well I have to admit it is pretty nice to know that I have all the hair
» » “cells” in my scalp. They are still there from 10-15 years ago, they
» » haven’t gone anywhere.
» »
» » They just need the proper kickstart.
» »
» » It is a little frustrating that it took them this long to figure this
» out
» » … I don’t really see why they couldn’t have
» more carefully compared
» » balding and non-balding scalp and figured this out 5 or even 10 years
» ago.
» »
» »
» » Oh well.
» »
» » Maybe Acell (or Histogen) jump start something related to these
» » malfunctioning stem cells, because if “Acell-ed grafts” are causing 2-3
» » additional surrounding hairs to also pop up in the balding area …
» perhaps
» » the Acell is signaling something to the surrounding “sleeping”
» follicles.
»
» Everything you say is ‘technically’ fully correct.

good thing we have ironman - the scientist, to verify the technicalities

33

» The more elegant way of solving this wld be to use the determinant of a
» matrix as these are all linear equations… but writing matrices in ASCII is …

Cool. And now tell me something about how to calculate the amount (below/above) of the matrix cells (follicle bulb) in case of internal cellular disruption (e.g through ‘accident’ during hair plucking) IF the disruption zone happend at the critical level at the so-called ‘line of Auber’?

If you can give me a hint - we may could incorporate our own hair research lab.

34

» They just need the proper kickstart.
»
» It is a little frustrating that it took them this long to figure this out
» … I don’t really see why they couldn’t have more carefully compared
» balding and non-balding scalp and figured this out 5 or even 10 years ago.
»
»
» Oh well.

Or …
http://www.theatlanticwire.com/opinions/view/opinion/Science-Reveals-the-Secret-of-Baldness-6446

“Breakthrough: Dr George Cotsarelis has spent years studying follicles in order to find the causes of hair loss”

Actually, this is not a ‘breakthrough’ - and besides ‘frustrating’, I simply would call this …

A JOKE!

35

» » The more elegant way of solving this wld be to use the determinant of a
» » matrix as these are all linear equations… but
» writing matrices in ASCII is …
»
» Cool. And now tell me something about how to calculate the amount
» (below/above) of the matrix cells (follicle bulb) in case of internal
» cellular disruption (e.g through ‘accident’ during hair plucking) IF the
» disruption zone happend at the critical level at the so-called ‘line of
» Auber’?
»
» If you can give me a hint - we may could incorporate our own hair research
» lab.

let me help both of you.

1: if you have 19 heads then you need at least 38 legs for a bipedal. That leaves an extra 14 legs so 7 animals must walk on all fours. Both of you seem to lose clarity in your thinking getting to the biger picture

2: The inability to differentiate a cell line of any sort may relate to intrinsic or extrinsic factors as anyone familiar with co-culture will explain. Extrinsic factors maybe auto-, para- crine or even anatomical so there is someway to go. Genotyping, sequencing and even pharmacogenomics may help but if the factors are extrinsic then they may not help too much. Essentially no one has a monopoly of wisdom in this area.

I am a 20 year post doc and CEO of a biotech company, having been a director in big pharma. Frankly ironman I find you arrogant and condescending which is the tone of this post and not very attractive as you can see.

36

» let me help both of you.
»
» 1: if you have 19 heads then you need at least 38 legs for a bipedal. That
» leaves an extra 14 legs so 7 animals must walk on all fours. Both of you
» seem to lose clarity in your thinking getting to the biger picture

What the hell … ??

» 2: The inability to differentiate a cell line of any sort may relate to
» intrinsic or extrinsic factors as anyone familiar with co-culture will
» explain. Extrinsic factors maybe auto-, para- crine or even anatomical so
» there is someway to go. Genotyping, sequencing and even pharmacogenomics
» may help but if the factors are extrinsic then they may not help too much.
» Essentially no one has a monopoly of wisdom in this area.

What the hell … ??

» I am a 20 year post doc and CEO of a biotech company, having been a
» director in big pharma. Frankly ironman I find you arrogant and
» condescending which is the tone of this post and not very attractive as you
» can see.

What the hell …??

Anyway, hopefully you have more success with your “concealer-geometry” …

http://www.hairsite.com/hair-loss/personal_journal-pj-109.html

37

Iron man - you may be a prick to a large number of people including me but you are one of the BEST information researchers by far on this board.

I think Freddie555 makes a fair point.

38

» Iron man - you may be a prick to a large number of people including me
» but you are one of the BEST information researchers by far on this board.
»
»
» I think Freddie555 makes a fair point.

Point!?!? Because of pencil diks like iron_bytch most of the informed, decent, and intelligent fellas are not only hesitant in posting and/or joining, but the existing good fellas and smart dudes simply stop posting all together, i.e. Cal. Besides, what else would you expect from someone who has no job, lives off public assistance, lives in his mother’s basement, has virtually zero friends, no girl, no cable teleivision, and trolls dozens of forums online literally 18 hours a day 7 days a week? The most action and thrills he gets out of his day is copying and pasting insulting pics and insulting remarks here - how pathetic is that? You give anyone as much time as he spends, trolls, and lurks the internet and hairloss forums and I assure you by now they’d be pioneers in the industry. Sadly, if this tweezer jer-off put this much time & energy into ANY field, he MIGHT be someone today. Many yrs ago granted we had a-holes, the sites were usually moderated. Today, it’s all BS allowing cok suckers like this douchebag to post freely yet ban anyone on the hair transplant forum that gets close to revealing the truth about a hair transplant docotor. I’d rather have an informed, honest and intelligent conversation with someone over a disrespectful, rude, arrogant, prick, self-proclaimed-hairloss-guru any given day. After relentless email and notifications sent to hairsite, what was hairsite’s response? A “thread” warning him. What a joke, what a publicity stunt. Why not simply send him a private email and ban the fag for a few days to get the point acorss? Because obviously the tree hopper still hops freely.

I LITERALLY can’t read a SINGLE thread in this forum without coming across a ridiculous post of his attacking someone. Gets pretty fukcing annoying after awhile.

Btw marco, don’t even get yourself caught with this BS. You’re way too informed and much of a good dude to stoop to his level in the negative digits.

39

So does that mean that all you guys agree that Dr. Cotsarelis’ new study has some degree of BS ?

40

» » » The more elegant way of solving this wld be to use the determinant of
» a
» » » matrix as these are all linear equations…
» but
» » writing matrices in ASCII is …
» »
» » Cool. And now tell me something about how to calculate the amount
» » (below/above) of the matrix cells (follicle bulb) in case of internal
» » cellular disruption (e.g through ‘accident’ during hair plucking) IF the
» » disruption zone happend at the critical level at the so-called ‘line of
» » Auber’?
» »
» » If you can give me a hint - we may could incorporate our own hair
» research
» » lab.
»
» let me help both of you.
»
» 1: if you have 19 heads then you need at least 38 legs for a bipedal. That
» leaves an extra 14 legs so 7 animals must walk on all fours. Both of you
» seem to lose clarity in your thinking getting to the biger picture
»
» 2: The inability to differentiate a cell line of any sort may relate to
» intrinsic or extrinsic factors as anyone familiar with co-culture will
» explain. Extrinsic factors maybe auto-, para- crine or even anatomical so
» there is someway to go. Genotyping, sequencing and even pharmacogenomics
» may help but if the factors are extrinsic then they may not help too much.
» Essentially no one has a monopoly of wisdom in this area.
»
» I am a 20 year post doc and CEO of a biotech company, having been a
» director in big pharma. Frankly ironman I find you arrogant and
» condescending which is the tone of this post and not very attractive as you
» can see.

With all due respect it’s easy on small set of variables but becomes far more difficult with more complex problems… my formalism is universal (you can add a third, forth or n-th animal to the equation - or simply vectorize it and use a matrix). It seems YOU are lacking the “bigger picture”.

nevertheless i have no doubts of your expertise in your field of biotech and find it great to have someone like you on board this forum. I wish you would chime in more often so we cld get more qualified statements on the ongoing events.