The mice in the experiment Kligman moved human vellus hairs to that regrew to 50% of normal hair size (while donor hairs also grew to 50% of normal hair size on the same mice at 22 weeks), were SCID mice without an immune system. These are not the healthiest little creatures on earth. Their androgen levels might have been very low…
The reason I speculate that their androgen levels were probably low is because a RU58841 study was done with human MPB hairs transplanted to mice. Only 2% of the control mice regrew the MPB hairs for a second cycle, while 28% of the RU58841 mice did (they didn’t use nearly enough RU58841…something like .1% or less…so they didn’t get enough androgen receptors blocked). These mice probably had normal testosterone profiles if they were testosterone conditioned mice being studied for a baldness indication.
If you moved your “vellus” hairs to your leg, they will still be uptaking androgens via the androgen receptors on the hair and will remain suppressed. Their DNA does not change when they are moved. To get the vellus hairs to possibly regrow, we’d have to remove androgens and somehow get the immune system to not attack them anymore, and we’d probably need some growth stimulant on top of that. …Or we would need to change the DNA in the vellus hairs somehow so they weren’t suppressed by androgens. That isn’t going to be happening in the near future so its a moot point.
The “back of the leg” idea WOULD BE A GOOD IDEA for HM cell injections in my opinion. I wish they would do this. I still have a firm belief that the MPB-area scalp is changed enough through the chronic inflammation as to be a very bad environment for these cells to “make” hairs up there. I’d love to see what the results would be if the HM-cell-injections were done on the thigh…allowed to grow…and then transplanted to the scalp. I bet they’d have a hell of alot more success with fully differentiated hairs up there than mere cells. If they can grow the hairs in a tissue matrix outside the body (what Aderans is rumored to be working on if you look at one of their patents), then I see no reason for the yield not to be very good when injected. In short, I think the changes in bald scalp via the immunological baldness process is what is giving HM trouble as far as results.
The very same thing may trouble follica…hence why you see me wanting to see them also trying to “thicken up” the donor area of these men and see if better results are seen there, thus making more hair back there for transplantation later.