HOT Damn! Nearly 100% of mice subjects had full reversal!

Stem cell; cell based hair therapy
1

Stress-blocking drug restores hair in bald mice

CHICAGO, Feb. 16, 2011 (Reuters) — U.S. researchers studying the effects of stress on the gut may have stumbled on a chemical compound that stimulates hair growth. Scientists have reversed genetically induced baldness in mutant mice by injecting a stress-blocking compound called astressin-B. In row A, four month old mice were injected once daily for five days with the drug. Row B shows the mice three days after the last injection, and row C shows the same mice four weeks after the last injection.

“Almost 100 percent of the mice responded. The hair grows back fully. It is a very dramatic effect,” Million Mulugeta of the University of California at Los Angeles, who worked on the study, said in a telephone interview.

Moulage said the findings could open new areas of research on hair loss in humans, especially in people whose hair loss is caused by stress and aging.

The team, which included researchers from the Veterans Administration and the Salk Institute for Biological Studies in California, had been experimenting on mice that were genetically altered to overproduce a stress hormone called corticotrophin-releasing factor or CRF.

As these chronically stressed mice age, their hair turns gray and eventually falls off their backs. Mulugeta likens the effect to watching a U.S. president age over the course of two four-year terms in the White House.

The team injected these mice with a stress-blocking chemical compound called astressin-B, which blocks the action of the stress hormone CRF.

The mutant mice got a daily injection of the compound over five days, then the team measured the effects of this drug on their colons and put the mice back in their cages.

“When we came back three months later, their hair had all grown back. They were not distinguishable from their littermates who were not genetically altered,” Mulugeta said.

“It was totally unexpected.”

The effect lasted up to four months, a relatively long time in the life span of a mouse, Mulugeta said. Follow-up studies confirmed the findings.

The team also tested the compound in younger, mutant mice that had not yet lost their hair, and found astressin-B kept them from going bald.

“Not only does it restore hair, but it also prevents hair loss,” Mulugeta said.

2

It has been stated before that its harder to make a mouse lose hair than to grow hair…

i wldnt be surprised if smearing peanut butter on their backs would regrow hair… it has been shown time and time again that what works for mice… does not necessarily work for humans.

» Stress-blocking drug restores hair in bald mice
»
» CHICAGO, Feb. 16, 2011 (Reuters) — U.S. researchers studying the effects of
» stress on the gut may have stumbled on a chemical compound that stimulates
» hair growth. Scientists have reversed genetically induced baldness in
» mutant mice by injecting a stress-blocking compound called astressin-B. In
» row A, four month old mice were injected once daily for five days with the
» drug. Row B shows the mice three days after the last injection, and row C
» shows the same mice four weeks after the last injection.
»
»
»
» “Almost 100 percent of the mice responded. The hair grows back fully. It
» is a very dramatic effect,” Million Mulugeta of the University of
» California at Los Angeles, who worked on the study, said in a telephone
» interview.
»
» Moulage said the findings could open new areas of research on hair loss in
» humans, especially in people whose hair loss is caused by stress and
» aging.
»
» The team, which included researchers from the Veterans Administration and
» the Salk Institute for Biological Studies in California, had been
» experimenting on mice that were genetically altered to overproduce a stress
» hormone called corticotrophin-releasing factor or CRF.
»
» As these chronically stressed mice age, their hair turns gray and
» eventually falls off their backs. Mulugeta likens the effect to watching a
» U.S. president age over the course of two four-year terms in the White
» House.
»
» The team injected these mice with a stress-blocking chemical compound
» called astressin-B, which blocks the action of the stress hormone CRF.
»
» The mutant mice got a daily injection of the compound over five days, then
» the team measured the effects of this drug on their colons and put the mice
» back in their cages.
»
» “When we came back three months later, their hair had all grown back. They
» were not distinguishable from their littermates who were not genetically
» altered,” Mulugeta said.
»
» “It was totally unexpected.”
»
» The effect lasted up to four months, a relatively long time in the life
» span of a mouse, Mulugeta said. Follow-up studies confirmed the findings.
»
» The team also tested the compound in younger, mutant mice that had not yet
» lost their hair, and found astressin-B kept them from going bald.
»
» “Not only does it restore hair, but it also prevents hair loss,” Mulugeta
» said.

3

»
» Moulage said the findings could open new areas of research on hair loss in
» humans, especially in people whose hair loss is caused by stress and
» aging.

WTF???

The compound should be injected in humans right away to see what happens.

More and more I believe that baldness cure is just one of many suppressed cures.

4

You have enough faulty beliefs to fill a sinking ship.

» More and more I believe that baldness cure is just one of many suppressed
» cures.

5

» »
» » Moulage said the findings could open new areas of research on hair loss
» in
» » humans, especially in people whose hair loss is caused by stress and
» » aging.
»
» WTF???
»
» The compound should be injected in humans right away to see what happens.
»
» More and more I believe that baldness cure is just one of many suppressed
» cures.

Is this stuff available to the general public? Can anyone go out and buy it. Yes, it’s easier to grow hair on mice than humans but that does not mean that this stuff won’t grow hair on humans. It might!

6

» You have enough faulty beliefs to fill a sinking ship.

sorry to learn that you are retarded. It must be tough lacking intellectual skills.

7

I don’t think that peptide is available for purchase. However, I posted this in another thread. It is also a CRF blocker. There’s no way to know if this would work as well. Assuming that it is the blocking of CRF that causes the peptide to work, it’s possible. But somebody would have to purchase this and try it.

8

» I don’t think that peptide is available for purchase. However, I posted
» this in another thread. It is also a CRF blocker. There’s no way to know
» if this would work as well. Assuming that it is the blocking of CRF that
» causes the peptide to work, it’s possible. But somebody would have to
» purchase this and try it.
»
» http://www.tocris.com/dispprod.php?ItemId=5283

I think it would be best to get the one in the study beause it might work by a different mode of action also there is the chance that it could work by the same mode of action as the other one but the other one might not be as strong as the one in the study.

It is best to get the one in the study.

9

Well, of course. But you can’t get the one in the study. And when you can’t get the one in the study, you try and find something close.

10

if we will be to wait the clinical results we will only know this after years of study.

11

» Well, of course. But you can’t get the one in the study. And when you
» can’t get the one in the study, you try and find something close.

are you 100% sure we can not get the one in the study???

12

I’m not 100% sure, no. But I think it would be very difficult to get a custom made peptide like this, unless you new exactly what it was and had somebody make it up. I think getting something that works in a similar manner is the best bet if you want to try something now instead of waiting 5-10 years.

13

» I’m not 100% sure, no. But I think it would be very difficult to get a
» custom made peptide like this, unless you new exactly what it was and had
» somebody make it up. I think getting something that works in a similar
» manner is the best bet if you want to try something now instead of waiting
» 5-10 years.

I was reading where someone found something similar but it’s not a peptide. I think the one in the study is a peptide. So if one is a peptide and the other is not a peptide then that is a big difference and so it can’t just do a similar thing; it also has to be the same kind of drug/agent, and it also has to be similar in power. It has to be very similar, not just kind of similar so if the one in the study is a peptide then the one you would use would also have to be a peptide if you want any chance of it working.

14

Not true. In fact the drug I mentioned as well as the peptide have been used in other experiments with similar results (not hair related). That’s because they are both CRF blockers. The body doesn’t care whether it is a peptide or not.

The big thing is whether it is the CRF-blocking part is what is responsible for the hair growth. If it is, then what I linked to would be worth a try. Perhaps that’s not what is responsible for the hair growth. But perhaps it is. It’s too soon to tell.

So you can wait another 5-10 years to find out, or try something that is obtainable now. There’s no way to know without trying.

15

» Not true. In fact the drug I mentioned as well as the peptide have been
» used in other experiments with similar results (not hair related). That’s
» because they are both CRF blockers. The body doesn’t care whether it is a
» peptide or not.
»
» The big thing is whether it is the CRF-blocking part is what is responsible
» for the hair growth. If it is, then what I linked to would be worth a try.
» Perhaps that’s not what is responsible for the hair growth. But perhaps
» it is. It’s too soon to tell.
»
» So you can wait another 5-10 years to find out, or try something that is
» obtainable now. There’s no way to know without trying.

I think we should give it a try, how would you deliver it though, injections all over the scalp?

16

I was just reading an article about it on Sciencedaily, and I found this part about the fact they tried Minoxidil on the same mice interesting and promising.

So far, this effect has been seen only in mice. Whether it also happens in humans remains to be seen, said the researchers, who also treated the bald mice with minoxidil alone, which resulted in mild hair growth, as it does in humans. This suggests that astressin-B could also translate for use in human hair growth. In fact, it is known that the stress-hormone CRF, its receptors and other peptides that modulate these

Maybe there could be something to this.

17

» » You have enough faulty beliefs to fill a sinking ship.
»
» sorry to learn that you are retarded. It must be tough lacking intellectual
» skills.

It might be nice to be retarded; after all, you seem content.

18

I’d like to get excited about these findings, but there’s a long way to go from applying for a patent to having a marketable product.

» I was just reading an article about it on Sciencedaily, and I found this
» part about the fact they tried Minoxidil on the same mice interesting and
» promising.
»
» So far, this effect has been seen only in mice. Whether it also
» happens in humans remains to be seen, said the researchers, who also
» treated the bald mice with minoxidil alone, which resulted in mild hair
» growth, as it does in humans. This suggests that astressin-B could also
» translate for use in human hair growth. In fact, it is known that the
» stress-hormone CRF, its receptors and other peptides that modulate these
»
»
» Regrowing hair: Researchers may have accidentally discovered a solution | ScienceDaily
»
»
» Maybe there could be something to this.

19

» It has been stated before that its harder to make a mouse lose hair than to
» grow hair…
»
» i wldnt be surprised if smearing peanut butter on their backs would regrow
» hair… it has been shown time and time again that what works for mice…
» does not necessarily work for humans.

i would not disparage the findings in that way.

this looks like another interesting puzzle to hair (re)-growth.

20

» I don’t think that peptide is available for purchase. However, I posted
» this in another thread. It is also a CRF blocker. There’s no way to know
» if this would work as well. Assuming that it is the blocking of CRF that
» causes the peptide to work, it’s possible. But somebody would have to
» purchase this and try it.
»
» http://www.tocris.com/dispprod.php?ItemId=5283

Allright, who’s going to give this a shot?