Home | News | Find a Doctor | Ask a Question | Free

Histogen\'s new product


#1

Take a look at this: http://www.bionuesis.com/
Histogen has launched a new extracellular matrix product for humans use. It contains Laminin. Recall the Stanford study about Laminin and hair growth. Maybe we should contact Histogen and ask them what it can be used for? What they expect and think?


#2

» Take a look at this: http://www.bionuesis.com/
» Histogen has launched a new extracellular matrix product for humans use.
» It contains Laminin. Recall the Stanford study about Laminin and hair
» growth. Maybe we should contact Histogen and ask them what it can be used
» for? What they expect and think?

a “soluble human extracellular matrix”?

I remember suggesting we should try making Acell soluble (mix it with minox or emu oil), and apply it topically with the aid of a penetrating tool (like a dermaroller), so we can deliver it to our dormant follicles.


#3

» » Take a look at this: http://www.bionuesis.com/
» » Histogen has launched a new extracellular matrix product for humans
» use.
» » It contains Laminin. Recall the Stanford study about Laminin and hair
» » growth. Maybe we should contact Histogen and ask them what it can be
» used
» » for? What they expect and think?
»
» a “soluble human extracellular matrix”?
»
» I remember suggesting we should try making Acell soluble (mix it with
» minox or emu oil), and apply it topically with the aid of a penetrating
» tool (like a dermaroller), so we can deliver it to our dormant follicles.

God ! I remember that we talked about a solution at the cellular level and we tried to enumerate the players and I talked about the ones who are playing it behind the scenes. Histogen was just under the Radar. What a dramatic scenario the one we are living. I just hope a happy ending for it !


#4

» » » Take a look at this: http://www.bionuesis.com/
» » » Histogen has launched a new extracellular matrix product for humans
» » use.
» » » It contains Laminin. Recall the Stanford study about Laminin and hair
» » » growth. Maybe we should contact Histogen and ask them what it can be
» » used
» » » for? What they expect and think?
» »
» » a “soluble human extracellular matrix”?
» »
» » I remember suggesting we should try making Acell soluble (mix it with
» » minox or emu oil), and apply it topically with the aid of a penetrating
» » tool (like a dermaroller), so we can deliver it to our dormant
» follicles.
»
»
» God ! I remember that we talked about a solution at the cellular level and
» we tried to enumerate the players and I talked about the ones who are
» playing it behind the scenes. Histogen was just under the Radar. What a
» dramatic scenario the one we are living. I just hope a happy ending for it!

You and me both brother.


#5

Wow, very interesting indeed, I was holding out for the possibility that acell contained Laminin but now we have something that is confirmed, we just need to find out if it has Laminin-511 as thats the one that triggers hair regeneration:

"The Stanford University researchers said that the molecule, called
laminin-511, acts like an operator, transferring messages, or proteins,
between the outer and inner layers of skin, an exchange that ultimately
drives hair formation.

It is expected that laminin-511 could potentially regenerate the actual
follicles that grow hair, unlike existing products that slow hair loss.
“Loss of hair is not going to kill anybody. At the same time, for some
people, hair loss can be a really traumatic thing, especially for
women,” said Dr. Peter Marinkovich, the study’s senior author and an
associate professor at Stanford University’s School of Medicine.

In the study, mice injected with the purified molecule grew back hair in
two weeks, at half the thickness of a normal rodent.

Laminin-511 is an epithelial message promoting dermal papilla
development and function during early hair morphogenesis"

Someone should contact these guys asap, this could be very useful.

How do you know its from Histogen? I see no reference?


#6

» Maybe we should contact Histogen and ask them what it can be used
» for? What they expect and think?

“BioNuesis is a soluble human extracellular matrix grown under hypoxic conditions, developed as a culturing kit for stem cell growth. .”

Culturing kits are for lab use only! It’s of no use to humans.


#7

Reliable
Our manufacturing process and QC testing provide uniform ECM

Human Feeder Layer ECM
In a tube and ready to use, no messy gels

No Tumor Growth Factors

Laminin, Fibronectin & Collagen 4
BioNuesis contains only soluble, natural human ECM

All Human
Extracellular Matrix from human fibroblasts

Then why say this?
I thought it could be a similar ECM to Acell, but liquid. Could be more like a liquid used to grow cells in a culture though.

You can also buy cell culturing kits for home use, not that it would be useful to us, unless someone wants to multiply some DP cells and try a home made TRC lol :stuck_out_tongue:
But seriously that would be near impossible unless you had some sort of at home lab to keep the culture at the right conditions.

We need to contact the company to find out what exactly it is and what for.


#8

Ah I see, theres a link to it on histogens website.

BioNuesis new website launches on the 22/9/2008, so I guess we may know more then.


#9

» » Maybe we should contact Histogen and ask them what it can be used
» » for? What they expect and think?
»
» “BioNuesis is a soluble human extracellular matrix grown under hypoxic
» conditions, developed as a culturing kit for stem cell growth.
»
.”
»
» Culturing kits are for lab use only! It’s of no use to humans.

When there’s a will there’s a way :wink:
All you need to do is befriend someone at a lab.

.


#10

The thing that looks good is the fact that it has Laminin and is a liquid.

Thinking about it though, if it does contain laminin-511? if one could get hold of it, it could be made into a useful topical regardless of what it was originally intended for.

It even looks like a more basic version of Histogens hair loss product starting trials later this year, ReGenica:

http://www.histogeninc.com/products/regenica.htm

"ReGenicaTM is a proprietary liquid formula created by the culturing of newborn fibroblasts in an embryonic-like environment and then harvesting the naturally secreted growth factors, anitoxidants and other synergistic bioproducts that are produced. It is the first naturally stabilized and bioactive formulation of wnt proteins and natural cofactors - offering exceptional opportunities for applications including research tools and as a natural additive in products.
The formula contains naturally stabilized and bioactive wnt proteins with activity
The formula contains naturally secreted growth factors
ReGenicaTM is soluble and can be in both a topical or injectible format. injectible
The formula requires no purification process
Capabilities for Skin & Hair Care

ReGenicaTM is currently being researched as an additive to cosmeceutical products, with applications from post-resurfacing treatments to commercial anti-aging products.

The liquid formulation contains a complex mixture of actives, including human growth factors such as Keratinocyte Growth Factor, soluble human ECM such as collagen, and natural cellular antioxidants which supports the epidermal stem cells that renew skin throughout life.

In May 2008, an evaluation of ReGenicaTM’s as a treatment for post-laser patients was completed. Preliminary ‘proof of concept’ results from this first evaluation suggest that topical application of a skin gel supplemented with ReGenicaTM can provide overall improved visible re-epithelialization of post ablative laser facial skin, and thereby accelerate patient recovery, keeping superficial cutaneous side effects to a minimum. More details can be found within the news announcement at: http://www.histogeninc.com/aboutus/news_events.htm#8"

Additional studies are planned for late 2008, including further evaluation of ReGenicaTM as a treatment for post-resurfacing as well as preliminary evaluation of ReGenicaTM for anti-aging applications.

Histogen is also evaluating ReGenicaTM as an active ingredient for hair care products such as shampoos and conditioners. The Company anticipates ReGenicaTM’s interaction with hair follicles will help hair to grow thicker, stronger and more flexible.

Capabilities for Hair growth

Hair loss affects 35 million men and 21 million women in the United States.
One of Histogen’s significant applications for ReGenicaTM is its utilization as an injectable for hair growth. The combination of wnt proteins and growth factors making up ReGenicaTM has been shown to both stimulate resting hair follicles and induce new follicle formation.

In May 2007, these findings were substantiated by research performed byDr. George Cotsarelis, which offered further evidence that these growth factors and proteins in combination lead to a significant increase in the creation of new hair follicles in mice.
Histogen’s injectible ReGenicaTM for hair growth will begin clinical trials in Q4 2008, and launch is planned for 2015.


#11

» » Culturing kits are for lab use only! It’s of no use to humans.
»
» When there’s a will there’s a way :wink:
» All you need to do is befriend someone at a lab.

I appreciate your spirit But would you use motor oil as a sex lubricant??


#12

» » » Culturing kits are for lab use only! It’s of no use to humans.
» »
» » When there’s a will there’s a way :wink:
» » All you need to do is befriend someone at a lab.
»
» I appreciate your spirit But would you use motor oil as a sex lubricant??
Sounds kinky lol.

But seriously, if it’s determined to be safe on humans, and if it contains Laminin than why not give it a go. Sitting around and arguing isn’t going to get us anywhere. It’s time to get proactive.