Histogen’s HSC - Highly Anticipated Hair loss Treatment Due to Hit “Shelves” As

» Remember that the trialists in the preclinical trials were ONLY THINNING.
» No bald scalps were treated as far as I can remember, and the results were
» just Minoxidil-Class.
» But Naughton, in the 2nd video, is boldly talking about timelines “to get
» a full head of hair”, no less.
» Also, she seems satisfied with the efficacy observed in the preclinical
» trials and speculates using new sessions to add density, but at this point
» it is pure fantasy to speculate about this, because she doesn’t know if the
» results will be additive (most probably they won’t, as it happened with
» ICX-TRC).
» She seems satisfied with the efficacy in the preclinical trials, and she
» doesn’t talk about improving the efficacy per injection.
»
» She has not said anything about higher doses or improved formulations.
» Just repeated sessions. This seems to mean that the results we have seen so
» far can’t be improved rising the dose or improving the formulation, and its
» necessary to wait 3 months and inject again, and hopefully, see new
» hairs.
» It seems that she aims to reproduce full heads of hair with the current
» level of efficacy. I think this is impossible.
»
» As you see, everything is unknown, but Dr. Naughton is wet-dreaming about
» people flying to Asia in 2013 to get “full heads of hair”.
»
» @Rev:
» It is true that Histogen has done some good things. They have published
» pictures, which are top-notch, and they are proceeding quite fast, doing
» trials in foreign countries to cut-down costs, and speed everything up…
» also, they are going to test HSC on 50 trialists in Asia, in Phase I-II,
» so these are important trials.
» But the results are soso, and lately, I have seen a manipulative trend
» that reminds me of past charlatans. And I don’t like it.
»
» Regarding Washenik, I was very hard against him in the past, when he was
» constantly advertising HTs for Bosley, promising HM-timelines that never
» materialized.
» I said that “Washwenik was pathetic” after that sad interview when he
» dedicated most of the time to say how good were Propecia and Minoxidil.
» But now things have changed. ARI is doing multicentre Phase II trials in
» USA, ON VERY BALD PEOPLE, MEN AND WOMEN!!! It seems its 100 trialists.
» And Washenik is not giving interviews anymore (afaik). This means no
» propaganda, but real progress.
»
»
»
» » I truly don’t understand your resentment towards Histogen. They’ve been
» » upfront about everything thus far: from their lawsuit to how they’re
» » bracing their company against it… from their financial woes to how
» » they’ll raise funds to continue operations… from their trial
» commitments
» » to how they’ll deal with the corrupt little entity we know as the fda.
» »
» » They based HSC on a 7 year timeline, and there’s a slight chance we
» might
» » see this product slightly sooner. They even braced the public that HSC
» » won’t be a “DHT resistenant, one injection will give you a full head of
» » hair overnight” silver bullet. All-in-all, I like histogen because -
» unlike
» » aderans and follica - they’ve been transparent with their operations
» and
» » realistic with their goals.
» »
» » You keep cheering for Aderans, but what have they done for you
» lately…
» » except, that is, inundate us with a series of Washenik’s interviews
» where
» » he claimed their product is “less than 5 years away”. Don’t get me
» wrong, I
» » want Aderans to succeed as much as Histogen, but at this point I’m
» putting
» » more stock in the later.
» »
» »
» » » She is claiming victory even before the match has started.
» » » Very irresponsable or a plain charlatan.
» » » Lets wait for ARI’s phase II trial. Should be completed by the end of
» » the
» » » year.
» » » In the meantime, we will have fun with Dr. Naughton exagerations.
» » »
» » » Oh, still waiting for the promised Q&A… …
» …
» » »
» » »
» » » edit: I have just seen the video. Now I am even more pessimistic.
» » »
» » »
» » » » Histogen’s HSC - Highly Anticipated Hair loss Treatment Due to Hit
» » » » “Shelves” As Soon As 2013 - Dated 17th November
» » » »
» » » » Changing the lives of hair loss sufferers forever: Histogen Inc.
» » might
» » » be
» » » » doing just that, and sooner than many in the hair loss industry
» » » thought.
» » » »
» » » » Watch exclusive American Hair Loss Association Video Q&A of Dr.
» Gail
» » » » Naughton, Ph.D. as she answers user questions concerning Histogen’s
» » » Hair
» » » » Stimulating Complex’s availability, and how it might be used to
» » » effectively
» » » » treat hair loss in the very near future.
» » » »
» » » » See Link
» » » »
» » » »
» » »
» »

Even if it can’t grow hair on bald spots, it can still be an effective tool to battle hair loss. If you can increase your density by 25% where you DO have hair, then that’s 25% more hair that can be used for a HT. It’s not the silver bullet, but it’s certainly good enough for alot of people.

» Even if it can’t grow hair on bald spots, it can still be an effective
» tool to battle hair loss. If you can increase your density by 25% where you
» DO have hair, then that’s 25% more hair that can be used for a HT. It’s not
» the silver bullet, but it’s certainly good enough for alot of people.

As I said, I’m skeptical of Histogen. They seem desperate and their success hinges on this product. That being said, I don’t know why people only consider a “cure” (NW6 to NW1) success. If there’s a new product that can achieve even rogain-like results, that’s of significant value. If you don’t respond to any of the current protocols, maybe you would respond to a new protocol. Anything that works is another arrow in the quiver. So Histogen could increase yield by even 15%, that would be huge.

Anything that gains or preserves hair without causing collateral dick damage gets my vote.

Histogen’s method is supposed to be DP-cell induced, am I right? That points to a long-term gain against the lifetime accumulation of androgen damage. No previous product of any kind has ever done that. If it’s true then whatever Histogen comes up with would be a major step forward.

» Anything that gains or preserves hair without causing collateral dick
» damage gets my vote.
»
»
»
» Histogen’s method is supposed to be DP-cell induced, am I right? That
» points to a long-term gain against the lifetime accumulation of androgen
» damage. No previous product of any kind has ever done that. If it’s true
» then whatever Histogen comes up with would be a major step forward.

Exactly. A 10% or 15% increase may not do much for a NW5-6, but for a NW2-3 its the difference between visible baldness and a cosmetically full head of hair. And for non-responders to the Big Three, having a totally different approach would be valuable.

I think hairloss will be remedied incrementally long before some magical single treatment comes along. It will be a holistic protocol, including anti-andros, hair stimulants like Rogain and Histogen, and more advanced treatments like Aderans or Follica. In my opinion, there will still also be a place for high-quality FUE transplants as well.

On another note, I was recently reading “The Singularity” by Ray Kurtzweil (sp). He’s a pretty prescient futurist, and he’s written several books on near future development. If he is even half right about some of the advances in biotech in the coming decades, I’m confident that hairloss will be a thing of the past for the next generation. While it may still be a decade or more before we see a true “cure”, at least we can take solace in knowing that we are probably the last generation to ever have to suffer through hair loss.

» Exactly. A 10% or 15% increase may not do much for a NW5-6, but for a
» NW2-3 its the difference between visible baldness and a cosmetically full
» head of hair.

if the procedure is repeatable then should make the difference for everyone, even for a nw5, that’s the question: is the procedure repeatable? I guess yes

» » Exactly. A 10% or 15% increase may not do much for a NW5-6, but for a
» » NW2-3 its the difference between visible baldness and a cosmetically
» full
» » head of hair.
»
» if the procedure is repeatable then should make the difference for
» everyone, even for a nw5, that’s the question: is the procedure repeatable?
» I guess yes

keep guessing… maybe this guessing activity makes you grow more hair than HSC will do.

10% or 15% on the best cases, on thinning people who is not using Minox nor Finas!!
People who is already using Minox or Finas will probably see no benefit at all because they have already rejuvenated all the rejuvenable hairs.
And totally bald guys will see no significant benefit either.

Ooooh, 2013,what a beautiful date. We are just 3 years away. Get ready guys!! I think I am going to buy the plane tickets now, because in 2013 there will be a short supply!!

HAHAHAHA

» 10% or 15% on the best cases, on thinning people who is not using Minox
» nor Finas!!
» People who is already using Minox or Finas will probably see no benefit at
» all because they have already rejuvenated all the rejuvenable hairs.
» And totally bald guys will see no significant benefit either.

The benefits of Histogen have nothing to do with those of Minoxidil or Finasteride. Neither of the latter substances do any rejuvenation or damage repair whatsoever. Finasteride just stops (or slows) the damage to the hair follicle from accumulating, while Minoxidil just encourages damaged follicles to squeeze out more hair. Therefore, people who benefit from Minoxidil or Finasteride to the max would still benefit from Histogen.

» » » Exactly. A 10% or 15% increase may not do much for a NW5-6, but for a
» » » NW2-3 its the difference between visible baldness and a cosmetically
» » full
» » » head of hair.
» »
» » if the procedure is repeatable then should make the difference for
» » everyone, even for a nw5, that’s the question: is the procedure
» repeatable?
» » I guess yes
»
» keep guessing… maybe this guessing activity makes you grow more hair
» than HSC will do.
»
» 10% or 15% on the best cases, on thinning people who is not using Minox
» nor Finas!!
» People who is already using Minox or Finas will probably see no benefit at
» all because they have already rejuvenated all the rejuvenable hairs.
» And totally bald guys will see no significant benefit either.
»
»
» Ooooh, 2013,what a beautiful date. We are just 3 years away. Get ready
» guys!! I think I am going to buy the plane tickets now, because in 2013
» there will be a short supply!!
»
» HAHAHAHA

Jesus Christ, what’s wrong with this guy? There’s a difference between keeping a healthy skepticism and just being a douche.

» » 10% or 15% on the best cases, on thinning people who is not using Minox
» » nor Finas!!
» » People who is already using Minox or Finas will probably see no benefit
» at
» » all because they have already rejuvenated all the rejuvenable hairs.
» » And totally bald guys will see no significant benefit either.
»
» The benefits of Histogen have nothing to do with those of Minoxidil or
» Finasteride. Neither of the latter substances do any rejuvenation or
» damage repair whatsoever. Finasteride just stops (or slows) the damage to
» the hair follicle from accumulating, while Minoxidil just encourages
» damaged follicles to squeeze out more hair. Therefore, people who benefit
» from Minoxidil or Finasteride to the max would still benefit from Histogen.

Finas and Minox “rejuvenate” damaged follicles. Follicles who were producing a vellus hair are then able to produce terminal hairs. You see more terminal hairs. The same happens with HSC. Call it rejuvenation or whatever.

I think Histogen is rejuvenating hair follicles. This is why they test it in thinning scalps, not totally bald ones. If they tested it in totally bald scalps, they would get nothing, as there are no rejuvenable hairs. Same happens with Minox/Finas.

» Jesus Christ, what’s wrong with this guy? There’s a difference between
» keeping a healthy skepticism and just being a douche.

One thing is to use healthy sarcasm and humor, and another is using insults.
If you need to wash your vagina, sorry I can’t help you, watch anywhere else.:slight_smile:

Minox is like a way to temporarily buff/shine up a car’s dulling paint finish. It visually helps, but it doesn’t last unless it’s constantly reapplied. And in the case of Minox it doesn’t slow the damage process at all.

Fin/Dut are more like protectant wax layers to slow the ongoing damage. They also lend a slight cosmetic improvement just by their nature.

Anything, Histogen or otherwise, that works by rejuv-ing the DP cells, would be more equivalent to respraying some amount of fresh paint onto the car. (Even if it’s a very slight amount.) It’s a reversal of the root damage process that is not comparable to any of the other previous methods of preservation.

It’s difficult not to get a little bit excited about Histogen if this data continues to prove legit at all. Because if they can spray a thin layer of new paint onto the car with one round of injections, then I would expect the process to work several more times for several times to gains.

Okay, here is the deal.
The results so far are very dissapointing, and Dr. Naughton has behaved quite strange and erratic. No answers to the Q&A, no data at 5 months, and now drawing fantastic timelines.

Still, they are going to conduct trials on 50 trialists. This is a decent amount. The proper thing to do now is to wait for this trial, and ignore any fantasy from Dr. Naughton.

» Minox is like a way to temporarily buff/shine up a car’s dulling paint
» finish. It visually helps, but it doesn’t last unless it’s constantly
» reapplied. And in the case of Minox it doesn’t slow the damage process at
» all.
»
» Fin/Dut are more like protectant wax layers to slow the ongoing damage.
» They also lend a slight cosmetic improvement just by their nature.
»
»
» Anything, Histogen or otherwise, that works by rejuv-ing the DP cells,
» would be more equivalent to respraying some amount of fresh paint onto the
» car. (Even if it’s a very slight amount.) It’s a reversal of the root
» damage process that is not comparable to any of the other previous methods
» of preservation.
»
»
»
»
»
» It’s difficult not to get a little bit excited about Histogen if this data
» continues to prove legit at all. Because if they can spray a thin layer of
» new paint onto the car with one round of injections, then I would expect
» the process to work several more times for several times to gains.

Is 2013 in the US or other countries?

» Okay, here is the deal.
» The results so far are very dissapointing, and Dr. Naughton has behaved
» quite strange and erratic. No answers to the Q&A, no data at 5 months, and
» now drawing fantastic timelines.
»
» Still, they are going to conduct trials on 50 trialists. This is a decent
» amount. The proper thing to do now is to wait for this trial, and ignore
» any fantasy from Dr. Naughton.
»
»
» » Minox is like a way to temporarily buff/shine up a car’s dulling paint
» » finish. It visually helps, but it doesn’t last unless it’s constantly
» » reapplied. And in the case of Minox it doesn’t slow the damage process
» at
» » all.
» »
» » Fin/Dut are more like protectant wax layers to slow the ongoing damage.
»
» » They also lend a slight cosmetic improvement just by their nature.
» »
» »
» » Anything, Histogen or otherwise, that works by rejuv-ing the DP cells,
» » would be more equivalent to respraying some amount of fresh paint onto
» the
» » car. (Even if it’s a very slight amount.) It’s a reversal of the root
» » damage process that is not comparable to any of the other previous
» methods
» » of preservation.
» »
» »
» »
» »
» »
» » It’s difficult not to get a little bit excited about Histogen if this
» data
» » continues to prove legit at all. Because if they can spray a thin layer
» of
» » new paint onto the car with one round of injections, then I would
» expect
» » the process to work several more times for several times to gains.

DON’T BE LAZY! watch the videos, read the thread!

» Is 2013 in the US or other countries?
»
»
»
» » Okay, here is the deal.
» » The results so far are very dissapointing, and Dr. Naughton has behaved
» » quite strange and erratic. No answers to the Q&A, no data at 5 months,
» and
» » now drawing fantastic timelines.
» »
» » Still, they are going to conduct trials on 50 trialists. This is a
» decent
» » amount. The proper thing to do now is to wait for this trial, and
» ignore
» » any fantasy from Dr. Naughton.
» »
» »
» » » Minox is like a way to temporarily buff/shine up a car’s dulling
» paint
» » » finish. It visually helps, but it doesn’t last unless it’s
» constantly
» » » reapplied. And in the case of Minox it doesn’t slow the damage
» process
» » at
» » » all.
» » »
» » » Fin/Dut are more like protectant wax layers to slow the ongoing
» damage.
» »
» » » They also lend a slight cosmetic improvement just by their nature.
» » »
» » »
» » » Anything, Histogen or otherwise, that works by rejuv-ing the DP
» cells,
» » » would be more equivalent to respraying some amount of fresh paint
» onto
» » the
» » » car. (Even if it’s a very slight amount.) It’s a reversal of the
» root
» » » damage process that is not comparable to any of the other previous
» » methods
» » » of preservation.
» » »
» » »
» » »
» » »
» » »
» » » It’s difficult not to get a little bit excited about Histogen if this
» » data
» » » continues to prove legit at all. Because if they can spray a thin
» layer
» » of
» » » new paint onto the car with one round of injections, then I would
» » expect
» » » the process to work several more times for several times to gains.

» Finas and Minox “rejuvenate” damaged follicles. Follicles who were
» producing a vellus hair are then able to produce terminal hairs. You see
» more terminal hairs. The same happens with HSC. Call it rejuvenation or
» whatever.
»
» I think Histogen is rejuvenating hair follicles. This is why they test it
» in thinning scalps, not totally bald ones. If they tested it in totally
» bald scalps, they would get nothing, as there are no rejuvenable hairs.
» Same happens with Minox/Finas.

The mechanisms by which Histogen, Minoxidil, and Finasteride work are completely different from each other. You just call them all by the same name, i.e. “rejuvenation”, and then declare that therefore they are somehow the same, which logically wrong to do. Neither Minoxidil nor Finasteride add a single hair generating cell to the follicle, Histogen does.

Now then, I lurk on these sorts of boards but have never posted before. One common theme on all of the boards I have lurked is the pessimism associated with balding blokes. Whilst I can appreciate that people have been disappointed with the whole ‘5 years from now’ time and again but I think we mustn’t assume that something is destined to fail just as we mustn’t assume that something will give us a full head of hair, we must keep an open mind.

As for the whole Histogen’s results were crap, well Phase I trials (which Histogen have just completed) are to test safety and tolerability of a drug and NOT efficacy (whether the drug actually works).

The tested range of doses will usually be a fraction of the dose that causes harm in animal testing. In context Histogen have used a single injection at a very low dose to test it’s safety and they have had some positive results from it. To expect a major increase in hair density at phase I is unrealistic. Considering that the trial was to test safety at a low dose and the fact that they have had some regrowth and thickening of hairs is positive in my book.

Phase II (to be conducted in Asia) will be at a clinical dose (the dose that the patient will get when it hits the market) and are designed to test the efficacy (if it works). We already know it works to an extent so it will be interesting to see if higher doses and/or more injections give greater density and cosmetically acceptable hair.

» Now then, I lurk on these sorts of boards but have never posted before. One
» common theme on all of the boards I have lurked is the pessimism associated
» with balding blokes. Whilst I can appreciate that people have been
» disappointed with the whole ‘5 years from now’ time and again but I think
» we mustn’t assume that something is destined to fail just as we mustn’t
» assume that something will give us a full head of hair, we must keep an
» open mind.
»
» As for the whole Histogen’s results were crap, well Phase I trials (which
» Histogen have just completed) are to test safety and tolerability of a drug
» and NOT efficacy (whether the drug actually works).
»
» The tested range of doses will usually be a fraction of the dose that
» causes harm in animal testing. In context Histogen have used a single
» injection at a very low dose to test it’s safety and they have had some
» positive results from it. To expect a major increase in hair density at
» phase I is unrealistic. Considering that the trial was to test safety at a
» low dose and the fact that they have had some regrowth and thickening of
» hairs is positive in my book.
»
» Phase II (to be conducted in Asia) will be at a clinical dose (the dose
» that the patient will get when it hits the market) and are designed to test
» the efficacy (if it works). We already know it works to an extent so it
» will be interesting to see if higher doses and/or more injections give

welcome. good post, makes sense.
» greater density and cosmetically acceptable hair.

Now then, I lurk on these sorts of boards but have never posted before. One common theme on all of the boards I have lurked is the pessimism associated with balding blokes. Whilst I can appreciate that people have been disappointed with the whole ‘5 years from now’ time and again but I think we mustn’t assume that something is destined to fail just as we mustn’t assume that something will give us a full head of hair, we must keep an open mind.

As for the whole Histogen’s results were crap, well Phase I trials (which Histogen have just completed) are to test safety and tolerability of a drug and NOT efficacy (whether the drug actually works).

The tested range of doses will usually be a fraction of the dose that causes harm in animal testing. In context Histogen have used a single injection at a very low dose to test it’s safety and they have had some positive results from it. To expect a major increase in hair density at phase I is unrealistic. Considering that the trial was to test safety at a low dose and the fact that they have had some regrowth and thickening of hairs is positive in my book.

Phase II (to be conducted in Asia) will be at a clinical dose (the dose that the patient will get when it hits the market) and are designed to test the efficacy (if it works). We already know it works to an extent so it will be interesting to see if higher doses and/or more injections give greater density and cosmetically acceptable hair.

Thank you Brit-lad. I’m glad someone else understands the distinction between Phase I & II. This forum is full of people eager to discredit Histogen because it’s safety trails didn’t yield full heads of hair on its test subjects. It’s exhausting to argue with those people.

» Now then, I lurk on these sorts of boards but have never posted
» before. One common theme on all of the boards I have lurked is the
» pessimism associated with balding blokes. Whilst I can appreciate that
» people have been disappointed with the whole ‘5 years from now’ time and
» again but I think we mustn’t assume that something is destined to fail just
» as we mustn’t assume that something will give us a full head of hair, we
» must keep an open mind.
»
» As for the whole Histogen’s results were crap, well Phase I trials (which
» Histogen have just completed) are to test safety and tolerability of a drug
» and NOT efficacy (whether the drug actually works).
»
» The tested range of doses will usually be a fraction of the dose that
» causes harm in animal testing. In context Histogen have used a single
» injection at a very low dose to test it’s safety and they have had some
» positive results from it. To expect a major increase in hair density at
» phase I is unrealistic. Considering that the trial was to test safety at a
» low dose and the fact that they have had some regrowth and thickening of
» hairs is positive in my book.
»
» Phase II (to be conducted in Asia) will be at a clinical dose (the dose
» that the patient will get when it hits the market) and are designed to test
» the efficacy (if it works). We already know it works to an extent so it
» will be interesting to see if higher doses and/or more injections give
» greater density and cosmetically acceptable hair.
»
» Thank you Brit-lad. I’m glad someone else understands the distinction
» between Phase I & II. This forum is full of people eager to discredit
» Histogen because it’s safety trails didn’t yield full heads of hair on its
» test subjects. It’s exhausting to argue with those people.

Rev you need word your lines a little more carefully. I wasn’t out to discredit histogen, I’ve always actually done the opposite to the pessimists. But that doesn’t mean I can’t voice a concern in hopes that it will become clarified by someone here. Do realize that some of us may not be reading here or posting here as often as you are or others are. And nobody is arguing with you and or anyone else nor do I invite an argument with anyone…why can’t people share views without resulting in arguing or fighting?

» Rev you need word your lines a little more carefully. I wasn’t out to
» discredit histogen, I’ve always actually done the opposite to the
» pessimists. But that doesn’t mean I can’t voice a concern in hopes that it
» will become clarified by someone here. Do realize that some of us may not
» be reading here or posting here as often as you are or others are. And
» nobody is arguing with you and or anyone else nor do I invite an argument
» with anyone…why can’t people share views without resulting in arguing or
» fighting?

I wasn’t talking about you. No need for the paranoia.