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Histogen launches All-Human Stem Cell Culturing Kit


#1

I also stumbled upon this while checking out the Histogen ISHRS stuff, sounds like they are doing something truly exciting!!

Histogen Launches BioNuesis, the Only All-Human Stem Cell Culturing Kit

SAN DIEGO, September 22, 2008 - Histogen, Inc., a regenerative medicine company developing solutions based on the products of newborn fibroblasts, today launched BioNuesis, the only soluble human extracellular matrix (ECM) developed as a culturing kit for stem cell growth. The kit was launched and is being exhibited at the 2008 World Stem Cell Summit taking place in Madison, Wisconsin.

Through its proprietary bioreactors, Histogen is uniquely capable of simulating the embryonic environment, creating products that are embryonic-like in nature without the utilization of embryonic stem cells. Products are developed by extracting the proteins and growth factors produced by these fibroblasts. In working with the unique liquid formulation, Histogen researchers identified the potential for the human soluble ECM in the field of stem cell research, as compared to currently available products.

“There is a significant need for an all-human ECM product that can support pluripotent huES cell expansion in culture, without the complications inherent with mouse tumor-derived ECM extracts that are still the best replacement for feeder-layer cells,” Dr. Jeanne Loring, Director of the Center for Regenerative Medicine at Scripps Research Institute. “Histogen’s technology may provide the solution and help accelerate both basic science and translational research using huES cells.”

BioNuesis is the first product that provides a limitless source of the natural human ECM proteins, such as laminin, collagen type 4 and fibronectin, which are required to expand human ES cells to commercial-scale.

Because current products utilize non-human sources, and can even contain mouse viruses, stem cell therapies developed using these animal products are not likely to be approved by the FDA. The technology behind the BioNuesis research kit, soluble natural human ECM, offers a solution which will eventually facilitate translation of stem cell cures to the public.

The launch of BioNuesis marks the entrance of Histogen into the marketplace as a number of products based on Histogen’s proprietary technology continue down the pipeline.

“Histogen is uniquely capable of utilizing every aspect of the liquid and solid created by the Company’s proprietary technology process, and developing high-value, all-human products at a commercial scale,” said Dr. Gail Naughton, CEO of Histogen. “We are excited to bring our first product to the stem cell research market, and look forward to launching products in the cosmeceutical and medical fields in the near future.”

About the World Stem Cell Summit
The World Stem Cell Summit, to be held Sept. 22-23, 2008 at Madison’s Alliant Center, is a gathering of scientists, company leaders, ethicists, investors and others. The Summit will provide an opportunity for the exchange of important stem cell information among key players from throughout the globe. The event will coincide with the 10-year anniversary of UW-Madison scientist James Thomson becoming the first to successfully isolate and culture human embryonic stem cells. For more information about the Summit, visit www.worldstemcellsummit.com.


#2

Nice!
And now!
Histogen works!
Make they a trail 2.
Need histogen the fda!
When can we get it?I dont want wait to 2015 if it works now!


#3

» Nice!
» And now!
» Histogen works!
» Make they a trail 2.
» Need histogen the fda!
» When can we get it?I dont want wait to 2015 if it works now!
And when it save is!
How is the problem???ß


#4

Is this stem cell culturing kit developed for hair growth? There is no mention in the article. Can you post the link?


#5

» Is this stem cell culturing kit developed for hair growth?

I don’t think so. And the article is old. Please, focus on Histogen’s REGENICA (now rebranded as HSC-Hair Stimulating Complex). This is the product to watch.


#6

is a matrix that provides a good productions of stem cells, for any use, i think skin hairs bones… is like an “instrument” to promote te growth of cells. They will be use it for hairs sure, but they don’t speak about them.


#7

» is a matrix that provides a good productions of stem cells, for any use, i
» think skin hairs bones… is like an “instrument” to promote te growth of
» cells. They will be use it for hairs sure, but they don’t speak about them.

If so, they will launch a specific product for hair, and they will tell us.
For now, the only thing for hair is Regenica a.k.a. HSC.


#8

It is for general use only, not for hair. It does make me wonder though, they can possibly use this for hair too. Isn’t Acell’s stuff also some kind of extracellular matrix (ECM)? Acell stuff is made from pigs and Histogen is made from humans, that’s the only difference.


#9

» It is for general use only, not for hair. It does make me wonder though,
» they can possibly use this for hair too. Isn’t Acell’s stuff also some kind
» of extracellular matrix (ECM)? Acell stuff is made from pigs and Histogen
» is made from humans, that’s the only difference.

You can email Dr. Naughton @Histogen and ask :wink:
But remember that Acell doesn’t seem to work for hair restoration.


#10

»
» You can email Dr. Naughton @Histogen and ask :wink:
» But remember that Acell doesn’t seem to work for hair restoration.

Acell hasn’t been adequately tested to know one way or the other.

I would admit the odds are probably not great. But we’d be stupid to completely write off this stuff based on what we know right now.


#11

Imagine the possibilities if we combine Histogen’s stem cells culture with their WNT injection and add to it Jones’ platelet rich plasma, wouldn’t it be great if this turns out to be the magic formula that we have all been waiting for :slight_smile: ? there has to be some synergies among these treatments, don’t you think?


#12

» Is this stem cell culturing kit developed for hair growth? There is no
» mention in the article. Can you post the link?

The article posted was from almost a year ago.


#13

» It is for general use only, not for hair. It does make me wonder though,
» they can possibly use this for hair too. Isn’t Acell’s stuff also some kind
» of extracellular matrix (ECM)? Acell stuff is made from pigs and Histogen
» is made from humans, that’s the only difference.

That’s a really good question …

“What happens if we put that by …” – hair follicles?

Actually, we already have the answer, because …

“In fact, it seemed to work - Eureka!

lol …


#14

some of us don’t want to wait years. Is there any way to use this kit to essentially create a reasonable facsimile of HSC-Hair Stimulating Complex? That is the point. The point is that we want to find a way to get a reasonable facimile of HSC-Hair Stimulating Complex that we can use until the real deal comes to market. Histogen is taking its’ sweet time. They could have, and should have started phase two this year, and they were going to, but then they announced a delay. I am tired of drug companies delays and time-wasting. They do not care about our situation; they care about profit only and I think we should strongly consider trying to find a way to get a reasonable facimile of HSC-Hair Stimulating Complex made on the side right now. If there is a kit out there that will make it possible to getHSC-Hair Stimulating Complex made then let’s do it. Histogen is wasting time.

» » Is this stem cell culturing kit developed for hair growth?
»
» I don’t think so. And the article is old. Please, focus on Histogen’s
» REGENICA (now rebranded as HSC-Hair Stimulating Complex). This is the
» product to watch.


#15

if the kit is out there then that means there’s a chance that it could be used to make a reasonable facimile of HSC-Hair Stimulating Complex. I think we should look into doing this. Histogen is wasting time - our time. They don’t really care when they launch HSC-Hair Stimulating Complex because sooner or later they will launch HSC-Hair Stimulating Complex, they will become profitable, and they will make their money. That is all that matters to them. But the quality of our real lives are on the line here and I think we should strongly consider getting a reasonable facimile of HSC-Hair Stimulating Complex made right now.

» It is for general use only, not for hair. It does make me wonder though,
» they can possibly use this for hair too. Isn’t Acell’s stuff also some kind
» of extracellular matrix (ECM)? Acell stuff is made from pigs and Histogen
» is made from humans, that’s the only difference.


#16

Look, if this kit can be used to make the types of substances that Histogen is developing then you have no reason to believe that it won’t create the substances used to make HSC-Hair Stimulating Complex. The point is that they may have just one kit and it may work to create all of the types of substances that histogen is working with, including the substances found in HSC-Hair Stimulating Complex. You have no reason to believe otherwise.

» »
» » You can email Dr. Naughton @Histogen and ask :wink:
» » But remember that Acell doesn’t seem to work for hair restoration.
»
» Acell hasn’t been adequately tested to know one way or the other.
»
» I would admit the odds are probably not great. But we’d be stupid to
» completely write off this stuff based on what we know right now.


#17

We have no reason to believe that the kit that Histogen put out will not produce the substances needed to make HSC-Hair Stimulating Complex. I think the greater likelihood is that this kit could be used to make HSC-Hair Stimulating Complex.

» » It is for general use only, not for hair. It does make me wonder
» though,
» » they can possibly use this for hair too. Isn’t Acell’s stuff also some
» kind
» » of extracellular matrix (ECM)? Acell stuff is made from pigs and
» Histogen
» » is made from humans, that’s the only difference.
»
» That’s a really good question …
»
» http://www.youtube.com/watch?v=3njZkP_3N48
»
» “What happens if we put that by …” – hair follicles?
»
» Actually, we already have the answer, because …
»
» “In fact, it seemed to work - Eureka!
»
» http://www.youtube.com/watch?v=_-HyF49K7qU
»
» lol …


#18

Even if it’s not for hair growth there might be a way to tweak it to turn it into a reasonable facimile of HSC-Hair Stimulating Complex. Of course the kit is not specifically for hair growth, but what can we do to the kit to turn it into something very similar to HSC-Hair Stimulating Complex? That is the million dollar question.

» » Is this stem cell culturing kit developed for hair growth? There is no
» » mention in the article. Can you post the link?
»
» The article posted was from almost a year ago.


#19

Maverick 11/27/10 3:45 am
Letter from Histogen.

“Thank you for your interest and message.

Histogen’s Hair Stimulating Complex (HSC) is currently in clinical trials as an injectable for hair regrowth in Male Pattern Hair Loss. More information, and the latest news from our pilot clinical trial of HSC, can be found on the news section of our website at: http://www.histogen.com/aboutus/news_events.htm#25.

Our next clinical trial is scheduled to begin in early 2011 in Singapore. While we don’t expect our product to be launched in the US until the 2015 timeframe, Histogen hopes that we can launch sooner outside the US if our international trials go well. However, that timeframe would also be a few years out. As an estimation, Histogen hopes to get product approval in Asia by mid-2013. Histogen expects that launching the HSC product in the EU will be around the same time as a US product in 2015. As the product progresses through development, Histogen will identify whether trials in the UK/EU are necessary.

As for hair loss in women, the Histogen team and hair specialists we work with believe that our product should work in women. While these initial studies are focused on male pattern hair loss, Histogen is considering a small side study for hair loss in women and diffused hair loss.

If I can answer any further questions, please feel free to contact me directly at the email below.

Best regards,

Thomas L Hubka

ReGenica Brand Manager”


#20

Iron_Man posted this ages ago :-/