» I don’t get how suppressing your immune system will help the follica
. Cylcosporin, Tacromilus, Pinecromilus and a couple of other immunosuppressants are mentioned in the patent as possible adjuvants to the process. The two getfitinib patients with freak hairgrowth were on chemotherapy, and had compromised immune systems. All of the SCID mice with human skin grafted onto them that grew human hair on their backs during the experiments were SCID mice, which means they dont have immune function at any legitimately functioning level. We have not seen experimental humans get hair growth in resonse to wounds yet that have working immune systems. This may be something (the immune system) that might have to be suppressed during the embryonic window after skin-reepilithialization post-epidermal disruption to get new hair, but we are hoping not.
Most people I know who have their immune system suppressed lose
» their hair. I am no doctor, but I think it has something to do with the
» brain. Just like a brain tumor will make someone grow extremely tall, some
» type of signal tells your hair to grow and stop growing. Maybe that is what
» happens with the follica procedure. the skin goes into embryonic state and
» with the right compound the brain tells the body to create stem cells and
» grow hair. The epidermal stem cells are creating the hair very near to the surface of the skin in response to epidermal disruption after the skin re-epilithializes on human skin grafted onto SCID mice, and larger and more numerous hairs are being created if epidermal growth factor is “blocked” by an antagonist of it or its receptor. More and larger hairs are also being created if androgens are blocked, potassium channel openers are used, keratinocyte growth factor is introduced, EDAR signalling is agonized, etc. They will be experimenting to find out the optimal pathways to either suppress or agonize.
I don’t think the founders of follica really know what caused
» the mice to grow hair. They know EXACTLY what caused the mice with human skin grafted onto their backs to grow HUMAN hair. They know what compounds they used and they are
» pretty confident that they can grown hair on a bald head with those
» compounds. They DIDN’T use ANY CHEMICAL COMPOUDS in some of the experiments and still got hair on SCID mice by simply using dermabrasion on them. These mice dont have immune systems though, and we do, so there is a big difference in the two dermal system’s response to wounds because of that.
I think this is the reason it is taking so long for the clinical
» trials to start. Actually clinical trials have been in recruitment and may have already started at HARVARD. They are simply going to wound men’s scalps (very shallow wounds like dermabrasion or laser resurfacing) and see pathways are active, what the immune system might be doing, etc. Hopefully they will find that the human immune system doesn’t have to be suppressed either locally or systemically to upreg the correct pathways for the epidermal stem cells to make hair in response to the epidermal disruption. We will see.
Suggestion: READ the patent and all of the experiments in the patent. It will take about one hour or so. Google “Follica and kits patent” and you should get the WIPO patent in page 2 or so. After reading it, you will know pretty much what happened in experiments and why they think they can make brand new hair to be made out of human skin on real people in a cosmetically pleasing way. There is a paper about this in the Journal, Nature, also.