(Baseline subject: I was poking around looking for any natural possibilities to mimic Gefilitnib/Erlonitib in the Folica stuff.)
The Folica patents were categorically saying “must be a non-natural EGF-R inhibitor” and I had believed that at the time. I once read something suggesting that the natural EGF-R inhibiting substances we were talking about at the time were also inhibiting WNT action. I assumed that was a good enough reason (although probably not the only reason) for Folica ruling out anything but the drugs. When we were talking about all this a year or two ago, I had been more focused on the EGF-R angle and less on the WNT angle than the mood has been lately.
Recently I was surfing around for Tyrosine Kinase inhibitors (TK inhibition seems to be the front-page therapueutical reason for docs to prescribe Gefilitnib & Erlonitnib to cancer patients) and started reading about Genistein. Genistein inhibits TK. There is even some moderate discussion of its effects on cancer cells like Gefilitnib & Erlonitib.
Now I’m trying to make heads or tails of what this might mean in regards to WNT signalling. They’re mucking around with several of our usual suspects (WNT 5a & 7a, DKK-1, etc):