Home | News | Find a Doctor | Ask a Question | Free

Follica - Retinoid


#1

A retinoid is in the patent, but nobody mentions trying it. Tretinoin disrupts skin cell growth in warts. Is this something that should be considered?

http://www.questdiagnostics.com/kbase/topic/detail/drug/tn8311/detail.htm


#2

» A retinoid is in the patent, but nobody mentions trying it. Tretinoin
» disrupts skin cell growth in warts. Is this something that should be
» considered?
»
» http://www.questdiagnostics.com/kbase/topic/detail/drug/tn8311/detail.htm

retinoids are certainly mentioned in the patents as adjuvants…

I keep going back to the human skin on a immunodeficient mouse example myself, in wondering what we could do to have success. Its experiment number 7 in the patent. They just depilated three days before abrasion and had hair placodes forming at day 7 post-wounding. They didn’t even inhibit EGF.

CMS, the “kit” that follica eventually comes up with will probably have a retinoid in its formulation. If I were good at kitchen sink chemistry (I have ten thumbs in this area), I’d probably try to add one—but Im not. They (retinoids) would probably add to the number of hairs or size of hairs, etc.

Here is everything Ive seen mentioned as “possibles” in the patent.

1-anti-androgen (finas, dutas, fluridil, spiro, ketoconazole, a few others)
2-channel opener (phenytoin, mionox, somthing else starting with “d”)
3-EGF-antagonist (getfitnib, erlonitib, and a bunch of others)
4-antiinflammatory (COX inhibitors of various kinds)
5-retinoid (trenitoin, retinoic acid, some others)
6-anti-histamine
7-anti-bacterial
8-anti-microbial
9-fiberblast growth factor
10-ectodyslplasin, called EDAR
11-beta catenin
12-wnt protiens (older patent)
13-lithium compounds

I think thats about it. I’d have to recheck and see if I missed a couple.

When I look at the various experiments with mice, they start using minox or FGF at day 11 on the mice, which should correspond to day 3 or 4 on us because we apparently heal more quickly, to get better results using the two substances. They also BLOCKED hair follicle formation by using Epidermal Growth Factor injections in the mice on day 11----which tells me that what happens before day 3 apparently doesn’t need much (if any) chemical help. They only warn you not to use any substance normally put on a wound to help it heal and to let it heal on its own.

It really does look like all they are going to do is wound, wait x-amount of days, start putting a topical on for about a week comprised of the some of the stuff above, wait for hair to sprout.


#3

» 5-retinoid (trenitoin, retinoic acid, some others)

nothing important, just to say that tretinoin and retinoic acid are the same thing, other retinoids : isotretinoin, tazarotene , adapalene


#4

» » A retinoid is in the patent, but nobody mentions trying it. Tretinoin
» » disrupts skin cell growth in warts. Is this something that should be
» » considered?
» »
» »
» http://www.questdiagnostics.com/kbase/topic/detail/drug/tn8311/detail.htm
»
»
»
»
» retinoids are certainly mentioned in the patents as adjuvants…
»
»
» I keep going back to the human skin on a immunodeficient mouse example
» myself, in wondering what we could do to have success. Its experiment
» number 7 in the patent. They just depilated three days before abrasion and
» had hair placodes forming at day 7 post-wounding. They didn’t even inhibit
» EGF.
»
»
» CMS, the “kit” that follica eventually comes up with will probably have a
» retinoid in its formulation. If I were good at kitchen sink chemistry (I
» have ten thumbs in this area), I’d probably try to add one—but Im not.
» They (retinoids) would probably add to the number of hairs or size of
» hairs, etc.
»
»
»
» Here is everything Ive seen mentioned as “possibles” in the patent.
»
» 1-anti-androgen (finas, dutas, fluridil, spiro, ketoconazole, a few
» others)
» 2-channel opener (phenytoin, mionox, somthing else starting with “d”)
» 3-EGF-antagonist (getfitnib, erlonitib, and a bunch of others)
» 4-antiinflammatory (COX inhibitors of various kinds)
» 5-retinoid (trenitoin, retinoic acid, some others)
» 6-anti-histamine
» 7-anti-bacterial
» 8-anti-microbial
» 9-fiberblast growth factor
» 10-ectodyslplasin, called EDAR
» 11-beta catenin
» 12-wnt protiens (older patent)
» 13-lithium compounds
»
»
» I think thats about it. I’d have to recheck and see if I missed a couple.
»
»
»
» When I look at the various experiments with mice, they start using minox
» or FGF at day 11 on the mice, which should correspond to day 3 or 4 on us
» because we apparently heal more quickly, to get better results using the
» two substances. They also BLOCKED hair follicle formation by using
» Epidermal Growth Factor injections in the mice on day 11----which tells me
» that what happens before day 3 apparently doesn’t need much (if any)
» chemical help. They only warn you not to use any substance normally put on
» a wound to help it heal and to let it heal on its own.
»
»
» It really does look like all they are going to do is wound, wait x-amount
» of days, start putting a topical on for about a week comprised of the some
» of the stuff above, wait for hair to sprout.

I was just thinking that Tretinoin may help keep the stem cells from forming skin and allow for more hair follicles to form, allowing for more density.