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Dr Garza identifies drug candidate for skin and hair regeneration


#1

The discovery, summarized in an article published Aug. 6 in the journal Cell Stem Cell, could, they say, eventually help spur the growth of new hair, skin or other organ tissue in scarred victims of burns and other injuries.

Our study “uncovers a novel role for a protein that works as a master regulator of regeneration in the skin,” says senior study author Luis A. Garza, M.D., Ph.D., associate professor of dermatology at the Johns Hopkins University School of Medicine. “Medications that turn on this protein have the powerful potential to decrease scarring as healing of wounds takes place, thereby promoting skin and hair follicle regeneration.”


#2

Sounds like only for scarring related hair loss?

“The clinical translation of this work is promising because work has already started, says Garza. Drug companies are already developing products to activate TLR3 to trigger the immune system, and these same products could be tested to promote regeneration. But Garza cautions that clinical applications of the team’s discoveries must await many more experiments and the development and testing of drugs that target the pathway they uncovered. He also made clear that the information might not be as applicable to conditions unrelated to scarring or to those whose hair follicles are lost from male pattern baldness.”


#3

[quote][postedby]Originally Posted by helpmeout[/postedby]
Sounds like only for scarring related hair loss? [/quote]

Yes, and I think that’s pretty weird. How could something grow hair in scar tissue but not in unscarred skin?


#4

Touche’

I think that if it will work to grow hair in scarred areas then it might
also regrow hair lost to pattern hair loss. He may just not want to go out
on a limb and state that YET.


#5

[quote][postedby]Originally Posted by helpmeout[/postedby]
Sounds like only for scarring related hair loss?

“The clinical translation of this work is promising because work has already started, says Garza. Drug companies are already developing products to activate TLR3 to trigger the immune system, and these same products could be tested to promote regeneration. But Garza cautions that clinical applications of the team’s discoveries must await many more experiments and the development and testing of drugs that target the pathway they uncovered. He also made clear that the information might not be as applicable to conditions unrelated to scarring or to those whose hair follicles are lost from male pattern baldness.”[/quote]

So what are these drugs in development and what stage are they at? For all we know they’re in
late phase 3 and might be available in the next 12 months. Does anyone know?


#6

I agree that Garza probably cautioned against MPB hopes just to keep the rabid expectations & attention down. He’s been in this game long enough to know what happens when you say anything openly hopeful about MPB progress.

If it only works for wound healing then we could wound our scalps simply enough. None of these “wounding” schemes ever call for anything serious.