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DKK-1 inhibitor patent

  1. The method of claim 1, wherein the antagonist is a peptide corresponding to the LRP-6 binding site of Dkk-1.

  2. The method of claim 1, wherein the antagonist is peptide A as set forth in SEQ ID NO:11.

  3. The method of claim 1, wherein the antagonist is an antibody that specifically binds Dkk-1.

  4. A method of treating an osteolytic lesion in a mammal comprising administering to a mammal in need thereof an effective amount of a GSK3β inhibitor, wherein said GSK3β inhibitor mimics positive Wnt signaling.

  5. The method of claim 8, wherein the GSK3β inhibitor is lithium chloride.

  6. A method of enhancing osteogenesis in a mammal comprising administering to a mammal in need thereof an effective amount of a Dkk-1 antagonist, wherein said Dkk-1 antagonist inhibits Dkk-1 activity on the Wnt signaling pathway.

  7. The method of claim 10, wherein said mammal is a human.

  8. The method of claim 10, wherein the antagonist is directed to human Dkk-1.

  9. The method of claim 10, wherein the antagonist comprises a peptide corresponding to the LRP-6 binding site of Dkk-1.

  10. The method of claim 10, wherein the antagonist is peptide A as set forth in SEQ ID NO:11.

  11. The method of claim 10, wherein the antagonist is an antibody that specifically binds Dkk-1.

http://www.freepatentsonline.com/y2005/0084494.html

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