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Could this cream help us?


#1

http://www.vaniqa.com/

This is used for facial hair removal. It is basically a by product of ornithin (aminoacid). Can this have any anti androgenic activity or does it take a completely different path?


#2

» http://www.vaniqa.com/
»
» This is used for facial hair removal. It is basically a by product of
» ornithin (aminoacid). Can this have any anti androgenic activity or does
» it take a completely different path?

why would it?
how would it?

Regards
Pete


#3

You do not want to use this on your scalp. It inhibits cell proliferation (it inhibits an enzyem that causes cell proliferation). This enzyme has nothing to do with the enzymes that promote the formation of DHT.


#4

» You do not want to use this on your scalp. It inhibits cell proliferation
» (it inhibits an enzyem that causes cell proliferation). This enzyme has
» nothing to do with the enzymes that promote the formation of DHT.

Is it so sure?
http://209.85.135.104/search?q=cache:QJAk69erxg8J:www.digitalnaturopath.com/cond/C66489.html+androgenic+eflornithine&hl=fr&ct=clnk&cd=15&gl=fr&ie=UTF-8
Scroll down this web page (2/3 of it) and you’ll see that eflornithine is listed as a 5ar inhibitor.

quote:
"If you have seen a medical doctor about hirsutism, you’re probably taking birth control pills, possibly in combination with one or more other drugs. Drugs to retard hirsutism fall into three broad categories:

  1. Androgen receptor blockers: Cyproterone, flutamide (Eulexin), and spironolactone (Aldactone).
  2. Androgen-suppressing agents: GnRH agonists (Lupron), estroprogestins (birth control pills), corticosteroids, and insulin-sensitizing agents (metformin/Glucophage).
  3. 5 alpha-reductase inhibitors: Finasteride (Proscar), eflornithine hydrochloride (Vaniqa).
    All of these drugs work to some extent. They have helped some women see measurable reductions in androgen levels and unwanted hair growth. Most have side effects. All are recommended in conjunction with birth control pills, partly to control the side effects of these medications."

#5

» » You do not want to use this on your scalp. It inhibits cell
» proliferation
» » (it inhibits an enzyem that causes cell proliferation). This enzyme has
» » nothing to do with the enzymes that promote the formation of DHT.
»
» Is it so sure?
» http://209.85.135.104/search?q=cache:QJAk69erxg8J:www.digitalnaturopath.com/cond/C66489.html+androgenic+eflornithine&hl=fr&ct=clnk&cd=15&gl=fr&ie=UTF-8
» Scroll down this web page (2/3 of it) and you’ll see that eflornithine is
» listed as a 5ar inhibitor.
»
» quote:
» “If you have seen a medical doctor about hirsutism, you’re probably taking
» birth control pills, possibly in combination with one or more other drugs.
» Drugs to retard hirsutism fall into three broad categories:
» 1. Androgen receptor blockers: Cyproterone, flutamide (Eulexin), and
» spironolactone (Aldactone).
» 2. Androgen-suppressing agents: GnRH agonists (Lupron), estroprogestins
» (birth control pills), corticosteroids, and insulin-sensitizing agents
» (metformin/Glucophage).
» 3. 5 alpha-reductase inhibitors: Finasteride (Proscar), eflornithine
» hydrochloride (Vaniqa).
» All of these drugs work to some extent. They have helped some women see
» measurable reductions in androgen levels and unwanted hair growth. Most
» have side effects. All are recommended in conjunction with birth control
» pills, partly to control the side effects of these medications.”

Is it absorbed locally or systemically via your scalp?

Regards
Pete


#6

No idea. Just raising the subject. I’ve read that systemic effets were possible in case of excessive dosage… I just thought some on this board could tell us more about this stuff. It seems this product is most unknown.


#7

“Eflornithine hydrochloride cream (Vaniqa®) is useful for topical treatment of hirsutism. The cream is the only agent that directly affects the cell cycle in the pilosebaceous unit (PSU). This is a potent, irreversible inhibitor of the enzyme ornithine decarboxylase, which is necessary for production of the polyamines that mediate cell migration, proliferation, and differentiation. Binding of DHT to the androgen receptor is associated with stimulation of ornithine decarboxylase synthesis and proliferation of hair matrix cells (28). Inhibition of this enzyme limits cell division and function.”

Still think its a good idea?


#8

» “Eflornithine hydrochloride cream (Vaniqa®) is useful for topical
» treatment of hirsutism. The cream is the only agent that directly affects
» the cell cycle in the pilosebaceous unit (PSU). This is a potent,
» irreversible inhibitor of the enzyme ornithine decarboxylase,
» which is necessary for production of the polyamines that
» mediate cell migration, proliferation, and differentiation.
» Binding of DHT to the androgen receptor is associated with stimulation of
» ornithine decarboxylase synthesis and proliferation of hair matrix cells
» (28). Inhibition of this enzyme limits cell division and
» function.”

»
» Still think its a good idea?

We can’t be that positive (I mean negative). The word “limits” is not so worrying as you seem to imply. You may be right Jtelecom but, after all, is shortening of the hair cycle not a characteristic of DHT related alopecia and is this shortening not more or less linked to a too rapid proliferation and division of cells…???


#9

Hair Removal Cream - http://stopgrow.com This product has really helped in my fight against hair!