Home | News | Find a Doctor | Ask a Question | Free

Chromosome 20, the gene variant that makes you bald


#1

Along with a particular variant of the androgen-receptor gene that 98.6% of bald men have vs. 76.1% of hirsute men, this chromome 20 genetic variation is THE gene that makes men have MPB. Its associated with other disorders as listed therein the wiki article.

I wonder if some guys can look at supposedly “effective” natural treatments to those “other disorders” associated with chromosome 20 and find something that is effective in interrupting this chemical pathway in a safe-side-effect-free way?

Here is an news video about the discovery of this gene, http://watch.ctv.ca/news/clip102095#clip102095
Very important find folks, as opposed to so much of the other bullsh%t discussed in the HM forum.


#2

Chromosome 20 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 20 spans around 63 million base pairs (the building material of DNA) and represents between 2 and 2.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 20 contains over 900 genes. New discoveries have recently linked this chromosome to the increasing suseptability to male-pattern baldness.

[edit] Genes
The following are some of the genes located on chromosome 20:

EDN3: endothelin 3
JAG1: jagged 1 (Alagille syndrome)
PANK2: pantothenate kinase 2 (Hallervorden-Spatz syndrome)
PRNP: prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
tTG:tissue transglutaminase (Celiac disease)
AHCY: S-adenosylhomocysteine hydrolase
ARFGEF2: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
GSS: glutathione synthetase
SALL4: sal-like 4 (Drosophila)
VAPB: VAMP (vesicle-associated membrane protein)-associated protein B and C
BMP2: Bone Morphogenetic Protein 2 (osteoblast differentiation)

[edit] Diseases & disorders
The following diseases are some of those related to genes on chromosome 20:

Adenosine deaminase deficiency
Alagille syndrome
Celiac disease
Maturity onset diabetes of the young type 1
Pantothenate kinase-associated neurodegeneration
Transmissible spongiform encephalopathy (prion diseases)
Waardenburg syndrome

I guess one could start doing google searches and see if any natural treatments are associated with helping any of the above mentioned diseases. Its kind of a long shot, but who knows. There looks like that there are 11 genes on this chromosome at least. Who knows which one “it” is…but it sure as hell is a start.

Everybody has androgen receptors that uptake DHT. Almost everybody has DHT (unless you are a pseudo hermpahrodite). Those AREN’T what genetically causes you to go bald, but something downstream after androgenic uptake. What is it?

Im sure none of the naysaying A$$H0LE$ who populate this forum will be willing to do ANY research, but they will be happy to kvetch like the little suckling babies that they are that this “doesn’t mean anything”, etc.


#3

You have requested access to the following article:

Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis .
Journal of Dermatological Science , Volume 36 , Issue 1 , Pages 25 - 32
T . Midorikawa , T . Chikazawa , T . Yoshino , K . Takada , S . Arase

To view this article, please choose one of your preferred Elsevier websites:

Access to the full-text of this article will depend on your personal or institutional entitlements.
Preferred Websites
Article via ScienceDirect

Article via Elsevier Health Sciences - Elsevier imprints, theclinics.com, and ophsource.org  

To skip this screen in the future, update your preferred Elsevier websites . To learn more, read help
Update My Preferred Elsevier Websites

Abstract
Background: Androgenic alopecia (AGA) is the most common type of baldness in men. Although etiological studies have proved that androgen is one of the causes of this symptom, the defined molecular mechanism underlying androgen-related actions remains largely unknown.

Objectives: To clarify the difference in the gene expression profile of dermal papilla cells (DPCs) in skin affected by baldness.

Methods: DNA macroarray study was carried out on cultured DPCs from AGA skin comparing with DPCs from skin that is not affected by baldness.

Results: From DNA macroarray analysis, we observed that 107 of the 1185 analyzed genes had differing expression levels. A marked difference was observed in the decreased gene expression of BMP2 and ephrin A3 and up-regulated in NT-4 gene. In order to clarify the roles of BMP2 and ephrin A3 in the hair follicles, we examined the proliferation of hair follicle keratinocyte and expression of a hair acidic keratin gene. Both BMP2 and ephrin A3 raised the proliferation rate of the outer root sheath cells (ORSCs) and induced gene expression in acidic hair keratin 3-II.

Conclusion: These results lead us to the hypothesis that both BMP2 and ephrin A3 function as hair growth promoting factors in the hair cycle.


#4

Celiac disease is also associated with alerations on chromosome 20. Some of you will probably get a kick out of this, but here is the alternative recommendatons for dietarily combating this condition:

NATURAL TREATMENTS FOR CELIAC DISEASE

Eliminate all foods containing gluten from the diet, including: Ale, Candy, ice cream, Baby cereal, Canned’ meats, ice cream cones, Beer biscuits, Coffee, instant and brewed, infant formula, Bread Liquors, Breakfast cereal, Coffee substitutes, Macaroni, Cake mixes, Cookies, Milk (malted and powdered), Cakes, Frankfurters, Noodles, Pudding mix, Tea, Pancake syrup, Salad dressings, Wheat flour, Pancakes, Soda crackers, Whipped cream substitutes, Potato chips, and Spaghetti.
While symptoms are evident: Follow a lactose-free diet.
Follow a low-fiber diet.
Avoid fatty foods.
IN ADDITION TO YOUR DALLY SUPPLEMENTS, TAKE:
Vitamin C: 1,000 mg, daily.
Vitamin E: 400 I.U. daily.
Beta-carotene: 10,000 I.U. daily.
Calcium: 1,000 mg, dally along with 400 mg. of magnesium daily,
Iron: 60 mg. daily if you have had a blood test that indicates you are iron deficient.


#5

Gene scan to predict hair loss

Male pattern baldness affects around 40% of men
Genes that may increase by seven-fold the risk of early baldness amongst men have been uncovered by a team of international researchers.

Analysis of DNA from 5,000 volunteers with and without male-pattern baldness found two stretches of the genome linked with the condition.

One in seven men have both genetic variants, Nature Genetics reported.

Being able to predict hair loss early could boost development of preventive treatments, the researchers said.

An initial study in more than 500 men with early onset hair loss and 500 men without the condition highlighted the two genetic regions which substantially increased the risk of baldness.

Male pattern baldness had a strong inherited aspect and understanding that may well lead to better treatments and novel approaches

Professor Val Randall, University of Bradford

One was the androgen receptor gene and has already been linked to male-pattern baldness.

The other region is on chromosome 20 and is nowhere near any known gene.
Male pattern baldness, or androgenic alopecia, was already k nown to be hereditary and partly caused by male sex hormones.

More work is needed to work out how this influences risk of baldness, the researchers said.

Their findings were confirmed by the researchers in other groups of people with androgenic alopecia - including women in which they found a weaker association - in the UK, Iceland and the Netherlands.

Inheritance

A second study also published in Nature Genetics found a similar link between hair loss and chromosome 20.

The German researchers said the androgen gene which until now had been the only gene identified with baldness was on the X chromosome which is inherited from the mother.

But chromosome 20 is inherited from both mother and father and may provide an explanation for similarities in hair loss between father and sons, they said.

Dr Tim Spector, from Kings College London, said they found around 14% of men carry both genetic variants.

"At the moment we have a fairly good diagnostic tool for people who might want to know whether they will lose their hair before they are 50.

“There probably won’t be many people who want to use that at the moment because there aren’t any preventive treatments.”

He added he hoped it would stimulate pharmaceutical companies to develop creams, gels or pills to prevent hair loss before it starts.

“The other thing is understanding how these genes actually work - it’s likely to provide use with new targets for gene therapy which is actually quite easy to deliver to the hair follicle.”

Professor Val Randall, from the Centre for Skin Sciences at the University of Bradford said the work was very exciting, although it was debatable whether men would benefit from finding out about their hair loss risk.

However she added: "It is always easier to prevent than replace hair growth.

“Male pattern baldness has a strong inherited aspect and understanding that may well lead to better treatments and novel approaches.”


#6

Very interesting post however I can’t help but feel any genetically related cure is decades away at best. Although on the plus side finding out the route of the problem can only be a good thing.

Great find, I’m going to read into it some more later - I should be studying DNA at this very moment anyway :stuck_out_tongue:

Funny how this post hasn’t been spammed by the usual clowns, perhaps scientific data scares them.