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Cell injections enlarging miniaturized follicles or growing new follicles?


#1

For those of you who think that cell injection technologies are only enlarging miniaturized follicles, and not actually growing brand new follicles, recall this:

There are basically 2 ways that these procedures are tested on mice before human clinical trials. The first is testing them by injecting the cells into the backs of mice bred for hairlessness. This is where the cells are injected directly into bald immune-deficient murine (mouse) tissue. Immune deficient mice are used so that the foreign cells won’t generate an immune response in the mice, killing them. In these tests brand new hairs have been shown to grow in certain circumstances. Obviously, the cells are not enlarging miniaturized follicles of any kind, because the bald mice have no miniaturized follicles, human or otherwise.

The more common, and better designed test is where actual human tissue is grafted onto the backs of immune-deficient mice. The human tissue is a surrogate for using actual humans in these experiments, which is not allowed without going through a complicated and expensive FDA application; therefore it’s ideal for researchers who want to test some sort of cellular or biological therapy without actually haven received approval for human clinical trials. The reason the human tissue is grafted onto the backs of mice is only to keep the human tissue alive – so essentially, this is a test on human tissue – NOT on mouse tissue.

In these tests where human tissue is grafted onto mice, THEY DO NOT USE BALD HUMAN SCALP TISSUE WITH MINIATURIZED FOLLICLES. Rather, they use human tissue taken from parts of the body which are hairless. Christiano and Jahoda, and other researchers, were actually using human foreskin tissue taken from new born infants:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856798/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856847/

See in the second article above, they say:

  1. “Neonatal foreskin was selected as non-hair-bearing recipient tissue because it would challenge the human dermal papillae not just to contribute to hair follicles within the skin, but rather, to fully reprogram the recipient epidermis to a follicular fate.

  2. “Per experiment, between 10 and 15 spheres were placed between separated foreskin epidermis and dermis, which was recombined and grafted onto SCID mice.

Human neonatal foreskin tissue, and the other types of human tissue used for these experiments, has no native hair, or exceedingly little. Therefore it is logical to conclude that most of the hair growing in these situations is brand new, and not derived from miniaturized follicles, MPB affected follicles, or other types of tiny vellus follicles.

So from the above, you can see that injecting cells (like pluripotent stem cell-derived DP cells) into human tissue grafted onto mice, and seeing new follicles grow there, is all the proof we really need that these procedures CAN GROW BRAND NEW HAIR FOLLICLES, not just enlarge existing follicles which have been miniaturized by MPB.

And if they can grow brand new hair follicles, then they can do so in unlimited amounts, and so these procedures are effectively a CURE for hair loss. Not something that will only benefit people with lots of miniaturized follicles, but with any degree of MPB.


#2

scientist pubblish only the successful research. we will never know the researcher failures. may be they have tried but it dosent work on humans

one of the question that i ve always wondered:
if jahoda tried to grow hair on his wife’s arm, do you really think that he has never tried to grow hair on the head of bald collegues or bald friends?


#3

[quote][postedby]Originally Posted by thedayafter[/postedby]
scientist pubblish only the successful research. we will never know the researcher failures.[/quote]

When trying to prove something is possible, the number of failures doesn’t matter. It only takes one success to prove something is possible.