“The authors of a study2 that used grapefruit juice to mask the taste of ethanol inadvertently discovered an interaction between grapefruit and the calcium channel blocker felodipine (Plendil.2”). They observed that patients who consumed grapefruit juice had felodipine plasma concentrations two to three times higher than normal levels
" The manufacturers of cyclosporine (Sandimmune, Neoral) and simvastatin (Zocor) have gone so far as to place warnings on their drugs’ package inserts.25,31,32"
Cyclosporine (Sandimmune, Neoral), tacrolimus (Prograf)
Increased drug exposure without effects on peak concentration may cause increased adverse events or toxicity evidenced by renal toxicity, hepatic toxicity, and increased immunosuppression.25-29”
Thats the website I got this from…apparently “Medications metabolized by intestinal CYP 3A4 that have a low oral bioavailability or a narrow therapeutic index are more likely to have clinically significant interactions with grapefruit products.9 Because medications metabolized extensively by intestinal CYP 3A4 generally have low oral bioavailability, and because grapefruit inhibits this metabolic pathway, higher plasma concentrations of these medications will result.”
I’ll ‘ballpark’ figure it, and reason that if felodopline (who names this stuff?) concentrations were 2-3 times as strong with grapefruit juice…then cyclo’s should be also. I guess 100 mgs becomes 2-300 mgs. The doc that was prescribing cyclo for 2 weeks was giving it at 200 mgs per day for five days and 100 mgs per day for five days.
The lowest dosage Ive seen for psoriasis is 250 mgs per day for someone of my bodyweight (2.5 mgs per kg).
I have a “feeling” that immunosuppression is important during re-epilithialization…which is going to happen around 5 to 8 days in all likleyhood, and probably sooner if I can keep my head “cool” as experiments have shown with cold therapy. If you think about it…it makes perfect sense. Experiments have shown that if there is inflammation with neo-natal mice, they dont develop hair follicles. In response to abrasion, the body is going to inflame the living hell out of an area with superoxides, cytokines, COX, and histamines and various other weapons at its disposal. Just as inhibitng wnt for the first few days during re-epilithialization causes hair to have pigment, the first few days post wounding are probably “the” time for the immune system to be suppressed. Once re-epilithialization is finished and the keratinocytes covering the wound get directed to start making a hair follicle, only chemical intervention would probably be able to thwart that process, like blocking wnt during that time “thwarts” any hair from developing.
Maybe its a go after all…I can indeed get my grubby little hands on grapefruit juice, and if I can make 1000 mgs into just 2000 mgs via its usage…that would give me “enough” for 10 good days of decent immunosuppression.
Maybe I’ll try it tonight after all…with what Ive got now.