» » this is one thing that i want to know, did they actually
» SHRINK/minuturaise
» » the hair after a few hair cycles OR did they just go dormant…there is
» a
» » big difference.
»
» What happens is that the PGD2 (or similar chemical) causes the follicles to
» gradually spend more and more time in resting phase (telogen). They
» basically GRADUALLY stop cycling. This causes a gradual miniaturization of
» the follicles.
»
» It doesn’t happen all at once. That is a simplistic (and wrong) way to
» look at it. The process happens gradually over time. Yes, it’s slower in
» some people, faster in others, but it’s basically a gradual process.
»
» It’s as if you stayed asleep, say, 30 minutes longer each day, for a number
» of days, until you were in a total coma, asleep all the time.
yeah
“mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2 expression to the skin, demonstrates
elevated levels of PGD2 in the skin and develops alopecia, follicular miniaturization, and sebaceous gland hyperplasia,
which are all hallmarks of human AGA. These results define PGD2 as an inhibitor of hair growth in AGA and
suggest the PGD2-GPR44 pathway as a potential target for treatment.”
» » » this is one thing that i want to know, did they actually
» » SHRINK/minuturaise
» » » the hair after a few hair cycles OR did they just go dormant…there
» is
» » a
» » » big difference.
» »
» » What happens is that the PGD2 (or similar chemical) causes the follicles
» to
» » gradually spend more and more time in resting phase (telogen). They
» » basically GRADUALLY stop cycling. This causes a gradual miniaturization
» of
» » the follicles.
» »
» » It doesn’t happen all at once. That is a simplistic (and wrong) way to
» » look at it. The process happens gradually over time. Yes, it’s slower
» in
» » some people, faster in others, but it’s basically a gradual process.
» »
» » It’s as if you stayed asleep, say, 30 minutes longer each day, for a
» number
» » of days, until you were in a total coma, asleep all the time.
»
» yeah
»
» “mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2
» expression to the skin, demonstrates
» elevated levels of PGD2 in the skin and develops alopecia, follicular
» miniaturization, and sebaceous gland hyperplasia,
» which are all hallmarks of human AGA. These results define PGD2 as an
» inhibitor of hair growth in AGA and
» suggest the PGD2-GPR44 pathway as a potential target for treatment.”
»
» http://www.hopkinsmedicine.org/dermatology/news/2012_stm_garza.pdf
So what is this stuff (a related metabolite,) 15-dPGJ?
I ask because this kind of shows that “things” that are related to PGD2 also cause hair loss and that is why I think that the combo of both bimatoprost and a PGD2 antagonist combined might have a synergistic effect to produce a better result than either compound by itself.
You see, we already know that bimatoprost by itself will produce about a 20% increase in hair thickness (if it’s formulated properly), and it does not even reduce PGD2, although it is effective on something similar to PGD2.
The below study’s results showed that this stuff 15-dPGJ completely stopped hair growth:
And the study also says that 15-dPGJ is a “derivative” of PGD2. Does this mean that by negating PGD2 we would also negate 15-dPGJ? I think it says that both PGD2 and 15-dPGJ bind to the same receptor so by blocking that one receptor with a PGD2 antagonist it seems like that would negate both PGD2 and 15-dPGJ.
» » » » this is one thing that i want to know, did they actually
» » » SHRINK/minuturaise
» » » » the hair after a few hair cycles OR did they just go dormant…there
» » is
» » » a
» » » » big difference.
» » »
» » » What happens is that the PGD2 (or similar chemical) causes the
» follicles
» » to
» » » gradually spend more and more time in resting phase (telogen). They
» » » basically GRADUALLY stop cycling. This causes a gradual
» miniaturization
» » of
» » » the follicles.
» » »
» » » It doesn’t happen all at once. That is a simplistic (and wrong) way
» to
» » » look at it. The process happens gradually over time. Yes, it’s
» slower
» » in
» » » some people, faster in others, but it’s basically a gradual process.
» » »
» » » It’s as if you stayed asleep, say, 30 minutes longer each day, for a
» » number
» » » of days, until you were in a total coma, asleep all the time.
» »
» » yeah
» »
» » “mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2
» » expression to the skin, demonstrates
» » elevated levels of PGD2 in the skin and develops alopecia, follicular
» » miniaturization, and sebaceous gland hyperplasia,
» » which are all hallmarks of human AGA. These results define PGD2 as an
» » inhibitor of hair growth in AGA and
» » suggest the PGD2-GPR44 pathway as a potential target for treatment.”
» »
» » http://www.hopkinsmedicine.org/dermatology/news/2012_stm_garza.pdf
»
»
»
»
» So what is this stuff (a related metabolite,) 15-dPGJ?
»
» I ask because this kind of shows that “things” that are related to PGD2
» also cause hair loss and that is why I think that the combo of both
» bimatoprost and a PGD2 antagonist combined might have a synergistic effect
» to produce a better result than either compound by itself.
»
» You see, we already know that bimatoprost by itself will produce about a
» 20% increase in hair thickness (if it’s formulated properly), and it does
» not even reduce PGD2, although it is effective on something similar to
» PGD2.
»
» The below study’s results showed that this stuff 15-dPGJ completely stopped
» hair growth:
»
» http://www.bernsteinmedical.com/hairtransplantblog/prostaglandin-discovery-may-lead-to-hair-loss-treatment-for-men-and-women/
»
» And the study also says that 15-dPGJ is a “derivative” of PGD2. Does this
» mean that by negating PGD2 we would also negate 15-dPGJ? I think it says
» that both PGD2 and 15-dPGJ bind to the same receptor so by blocking that
» one receptor with a PGD2 antagonist it seems like that would negate both
» PGD2 and 15-dPGJ.
bear in mind pgd2 is upregulated at inflammatary sites, hence why its possibly the reason why increased levels were deteced in those balding scalps. AND hence the reason why pgd2 levels get out of balance in mpb in the first place…sort your scalp health out and you will not go bald. I only wish i knew this last year.
Also bear in mind pgd2 is probably part of the hair cycle i.e it regultes the transition from telogen to anagen and vice versa, so a small amount is no cause for concern.
Using a pgd2 inhiboter may end up like minoxidil, use it constantly or lose it, we need to trick the body in to cycling the hairs.
i still think cox 2/5 lox inhibition together with wnt stimulation is a better way forward and will regenerate hairs, i will be trying this out on my temples soon.
» bear in mind pgd2 is upregulated at inflammatary sites, hence why its
» possibly the reason why increased levels were deteced in those balding
» scalps.
» AND hence the reason why pgd2 levels get out of balance in mpb in
» the first place…sort your scalp health out and you will not go
» bald. I only wish i knew this last year.
prostaglandins in general have DIFFERENT FUNCTIONS depending on where on the body they are located. In some places it drives inflammation and in some doesn’t.
» Using a pgd2 inhiboter may end up like minoxidil, use it constantly or lose
» it, we need to trick the body in to cycling the hairs.
right which sucks that there is no permanent way of reconfiguring your follicles to start cycling like normal…
» » bear in mind pgd2 is upregulated at inflammatary sites, hence why its
» » possibly the reason why increased levels were deteced in those balding
» » scalps.
» » AND hence the reason why pgd2 levels get out of balance in mpb in
» » the first place…sort your scalp health out and you will not go
» » bald. I only wish i knew this last year.
»
» prostaglandins in general have DIFFERENT FUNCTIONS depending on where on
» the body they are located. In some places it drives inflammation and in
» some doesn’t.
»
»
» » Using a pgd2 inhiboter may end up like minoxidil, use it constantly or
» lose
» » it, we need to trick the body in to cycling the hairs.
»
» right which sucks that there is no permanent way of reconfiguring your
» follicles to start cycling like normal…
yes there is - cox2/5lox inhibition and maybe some wounding.
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