Hi, so, for newbs, non-scientists like me, we know the fact that chemotherapeutics work by slowing down or completely inhibiting the growth of cells NON-SELECTIVELY, hence the effect on hair as well.
There are so many proteins involved in cancer growth, one of them is Akt. I’m not sure really which Akt affects hair growth since there are 3 forms of it Akt1 Akt2 Akt3.
We also have heard of Grape Seed Extract (Procyanidin B2) induces hair growth. But it also treats cancer via VEGFR inhibition. Now, does it also
affect Akt based on this study:
"The reduction in Akt activity by MSKE [Grape Skin Extract] is mediated through a reduction in Akt transcription…"
Then this study suggests it actually ACTIVATES Akt:
Grape seed extract induced nitric oxide mediated endothelial dependent relaxation through AKT/PI3 kinase pathway
Is my interpretation right?!
Other molecules also share the same confusion:
I. Activates Akt phosphorylation = good for hair loss
EGCG (green tea)
II. Deactivates Akt phophorylation
some references I’ve read EGCG promotes Akt activation, while one says otherwise.
I for one lost a lot of hair (all over my body and scalp) because of taking Guggul or Guggulsterone, a known weight loss ayurvedic supplement that I actually took for acne and not losing weight. THEN I FOUND OUT THE OTHER DAY THAT IT ALSO DEACTIVES Akt!!! AND THAT Akt IS IMPLICATED IN CANCER GROWTH, AND THAT GUGGUL IS USED TO TREAT CANCER AS WELL! CHEMOTHERAPEUTICS === POTENTIAL HAIR LOSS… RING A BELL NOW?
Can we have everybody’s input on this? I am SOOO CONFUSED.
Can whey increase Akt? I want all my scalp and body hair back !