» For what it’s worth, I’m getting near to calling my own experimenting so
» far as a failure.
»
» I definitely regrew from the dermabrasion (possibly even a little more
» than abrasion effects alone), but I don’t see enough to think I’ve hit on
» the Folica procedure yet.
»
»
»
»
» The reason I point this out here is that there were a few places where I
» inhibited the EGF-R during the wounding days, not just after.
»
»
» It lends me to think that the anti-inflammatory part of the process is
» probably a very necessary thing. If the inflammation issue really wasn’t
» relevant then I should have had a lot more growth by now.
»
» (Even if I didn’t do the rest of it exactly right either, I varied things
» all over. Time of wounding, depth of wound, etc. I should have sprouted
» SOMEWHERE if I had all the primary drug bases covered by using the EGF-R
» drug alone.)
Cal,
This is why I keep harping on Experiment number 7. The mice had human skin grafted on their backs and grew human hair on that skin. Then everyone with a sunburn should have had hair sprouting on their shoulders right? But they dont. What is the difference? The mice didn’t have immune systems in the series of experiments lumped in with experiment number 7.
The fact that animals can regenerate hair in response to a wound shouldn’t be all that much of a suprise given what we know about balding from Hideo Uno’s research on macaque balding and androgenic alopecia in humans. Humans have the immune system “get involved”, but macaques dont have this-—their hair just miniaturizes and they get terrific regrowth from finasteride and minoxididl, while humans only regrow hair that had been lost in the previous few years. Humans have excessive collagenous deposition, chronic inflammation, loss of a water layer, loss of fatty acids present in the scalp, crosslinked collagen in the root sheath, premature ageing of the scalp, etc. I’d love to be wrong about this, but I have a feeling------a creeping suspicion anyway, that Follica is going to find that a topical cream of tacromilus, or rampycin, or cyclosporin, or one of the others that are used for eczema or psoriasis commonly—will have to be used to make this thing go.
I really dont think the lack of a anti-microbial would be the difference. The inflammation angle (probably related to the immune system) could be a factor throwing a monkey wrench into the mix. I admit this heartily. I dont think animals get the inflammation that we get.
However Cal-----------------------lets “go back” to the getfitinib hair growth photos. Both people were on getfitinib, both had cancer, both probably (we know one did) had previously underwent chemotherapy which usually deeply compromises the immune system. They were inhibiting EGF. You were inhibiting EGF. What did they “do” that you didn’t? We know it takes a “wound”. In their case it was almost assuredly some mild sunburn. You abraded.
The difference is the immune status of the people at hand.
Im hoping one can just use a topical immunosuppressant cream (If Im right), but I also have a dreary feeling that system-wide immunosuppression just might be necessary. Lets hope not, but cyclo is already approved and has sales of one billion annually. So if it is, its no big thing. 10 days of cyclo isnt going to kill a healthy man.
I guess I should relate the results of my own experiments. Using lidocaine on my shoulder and the side of my chest…I got nothing on the shoulder, but I did TCA-peel the far left upper corner of my chest. I started the lidocaine cream immediately under a stretch mark (I used to be pretty built-up–and am smaller now) and waited three days above it. I looked pretty hard and didn’t see any hair before abrading this area. I have about three dark-babyish hairs above the stretch mark, and two smaller one’s below it. I dont remember seeing them before. I have a hairy chest though, so just to the right of this area the hair starts on my chest. The abrasion might have merely invigorated stem cells in the area and kickstarted hairs that would have fired up in a few years (we get hairier with age) anyway. The shoulder, where I really wanted to see results, had nada. Lidocaine cream is only four percent lidocaine, and has a bunch of other stuff in it that might interefere with this process. Using what you did would have been much much better. I think getfitinib would really be the best thing to use because of the two hair growth cases associated with it. Baccy is going to try tannic acid.
We also have to consider that perhaps after about day 12 or so past wounding, applying minoxidil might help steroid any hairs made up to larger sizes and get the ball rolling—but the two getfitinib photos probably didn’t have that going for them.
I hope they can reach results and hit market not over 2010 