Home | News | Find a Doctor | Ask a Question | Free

Androgen receptor co-activator Hic-5/ARA55


#1

Androgen receptor co-activator Hic-5/ARA55 as a molecular regulator of androgen sensitivity in dermal papilla cells of human hair follicles.

J Invest Dermatol. 2007 Oct;127(10):2302-6

Androgen site-specifically affects human hair growth after puberty through androgen receptors in the dermal papilla, which transactivate target genes acting in conjunction with co-activators.

To examine the regulation of androgen sensitivity in hair follicles, we focused on androgen receptor co-activator Hic-5/ARA55. Its interaction with transfected androgen receptor in beard dermal papilla cells was confirmed with mammalian two-hybrid assays.

The semiquantitative reverse transcriptase-polymerase chain reaction showed that Hic-5/ARA55 mRNA expression was high in dermal papilla cells from the beard and bald frontal scalp but low in cells from the occipital scalp. To determine whether Hic-5/ARA55 mRNA level correlates with its endogenous activity, we studied the effect of dominant negative Hic-5/ARA55 on transfected androgen receptor transactivation induced by R1881 using mouse mammary tumor virus-luciferase assays.

We found that it suppressed the transactivation by 64.5 and 71.4% in dermal papilla cells from the beard and bald frontal scalp, respectively, whereas it showed no significant effect in cells from the occipital scalp. Our findings suggest that Hic-5/ARA55 is a molecular regulator for androgen sensitivity in human hair follicles.


#2

SUMMARIZING….WHAT THIS MEANS?:angry:


#3

» SUMMARIZING….WHAT THIS MEANS?:angry:

You just don’t worry, follica will give you your hair back in some few months. Forget about receptors, activators, hics and aras.


#4

» » SUMMARIZING….WHAT THIS MEANS?:angry:
»
» You just don’t worry, follica will give you your hair back in some few
» months. Forget about receptors, activators, hics and aras.

In few months???:expressionless:


#5

» » » SUMMARIZING….WHAT THIS MEANS?:angry:
» »
» » You just don’t worry, follica will give you your hair back in some few
» » months. Forget about receptors, activators, hics and aras.
»
»
»
» In few months???:expressionless:

sorry, I meant some weeks


#6

» » » » SUMMARIZING….WHAT THIS MEANS?:angry:
» » »
» » » You just don’t worry, follica will give you your hair back in some
» few
» » » months. Forget about receptors, activators, hics and aras.
» »
» »
» »
» » In few months???:expressionless:
»
» sorry, I meant some weeks
this looks better:-P


#7

» » » » » SUMMARIZING….WHAT THIS MEANS?:angry:
» » » »
» » » » You just don’t worry, follica will give you your hair back in some
» » few
» » » » months. Forget about receptors, activators, hics and aras.
» » »
» » »
» » »
» » » In few months???:expressionless:
» »
» » sorry, I meant some weeks
» this looks better:-P

lol


#8

» » » » » » SUMMARIZING….WHAT THIS MEANS?:angry:
» » » » »
» » » » » You just don’t worry, follica will give you your hair back in
» some
» » » few
» » » » » months. Forget about receptors, activators, hics and aras.
» » » »
» » » »
» » » »
» » » » In few months???:expressionless:
» » »
» » » sorry, I meant some weeks
» » this looks better:-P
»
» lol

I asked him a few weeks ago.But he is a serious doctor, he has no clear answer.
They work with several laboratories worldwide, together with authorities and had to fight to the approval for its test on people begin to go.10 men and 10 women, probably.
They are somewhat quiet about the press, contrary to Intercytex or Follica.
Wait guys
sh*t…look to consarlis in german