Agian Cotsarelis...Within "five years"!

» They’re lying because everyone else in their industry generally lies in
» the same way. It’s NORMAL.

are they politicians ? Bad news :frowning:

» » Are you actually reading what I’m saying in any of these posts?
» »
» »
» » They’re lying because everyone else in their industry generally lies
» in
» » the same way. It’s NORMAL.

»
» its even simpler imho, cotsarelis says “uhm we think we could have a drug
» in 3 years from now on which will then go through trials”. And tv just
» plays “we think we could have a drug in 3 years from now on.” CUT.

Aside from Cotsarellis words, what about Daphne Zohar from Follica?
Didn’t she said that there was going to be a blazing fast “proof of concept” trial in a few months where this technique was going to be put under test??? Or did I dream it??

No, I didn’t dream it. Its here:
http://www.hairsite.com/hair-loss/forum_entry-id-26706.html

NOTE THE DATE OF THE ARTICLE: 04-January-2008. It was 1 year ago, and still no news of the trial.

Zohar says Follica has further developed this work and filed additional patents to protect the technology. What’s so beautiful about the approach, she says, is that translating it into a treatment for humans involves only devices and drugs that are already on the market. A doctor would first use a microdermabrasion tool, say, or a laser to remove the top layers of the skin—as is already commonly done in a number of dermatologic and cosmetic procedures—knocking some cells back into a primitive state. The doctor can then use this newly created therapeutic window to inject drugs that push the cells to develop along one pathway or another and grow hair or skin. Zohar won’t reveal what drugs Follica is using, except to say that they are small molecule drugs normally taken orally for purposes with no relation to hair growth.

Because the components of the system are already approved, the regulatory path is pretty straightforward, and Follica can perform human studies without jumping through a lot of governmental hoops. That’s exactly what the company plans to do with the money it has just raised. A proof of concept study involving 15 to 20 patients (Follica has no shortage of volunteers, as several hundred people sent in e-mails when word of Cotsarelis’s work reached the public) should begin in the next few months. The trial has several phases, however, and Zohar cautions that final data won’t be in for at least a year. So don’t pull your hair out waiting for results.

<<<<<<<<<<<

» » In May 2007 cotsarelis said “2/3 years”, now “within 5 years”…He thinks
» » only of himself … Our hopes are closes: we live our lives by bald!
» »
» »
» http://www.citypaper.net/articles/2009/01/22/george-cotsaleris-hair-follicle-research
»
»
» But isn’t this the Follica stuff? The stuff that doesn’t require clinical
» trials because they are using already approved drugs?? and there was a
» superfast trial “proof of concept” trial being done in a few months with a
» few volunteers? Hellooooo? Is my memory inventing all these things?? Am I
» going crazy??

Here:

Aside from Cotsarellis words, what about Daphne Zohar from Follica?
Didn’t she said that there was going to be a blazing fast “proof of concept” trial in a few months where this technique was going to be put under test??? Or did I dream it??

No, I didn’t dream it. Its here:
http://www.hairsite.com/hair-loss/forum_entry-id-26706.html

NOTE THE DATE OF THE ARTICLE: 04-January-2008. It was 1 year ago, and still no news of the trial.

Zohar says Follica has further developed this work and filed additional patents to protect the technology. What’s so beautiful about the approach, she says, is that translating it into a treatment for humans involves only devices and drugs that are already on the market. A doctor would first use a microdermabrasion tool, say, or a laser to remove the top layers of the skin—as is already commonly done in a number of dermatologic and cosmetic procedures—knocking some cells back into a primitive state. The doctor can then use this newly created therapeutic window to inject drugs that push the cells to develop along one pathway or another and grow hair or skin. Zohar won’t reveal what drugs Follica is using, except to say that they are small molecule drugs normally taken orally for purposes with no relation to hair growth.

Because the components of the system are already approved, the regulatory path is pretty straightforward, and Follica can perform human studies without jumping through a lot of governmental hoops. That’s exactly what the company plans to do with the money it has just raised. A proof of concept study involving 15 to 20 patients (Follica has no shortage of volunteers, as several hundred people sent in e-mails when word of Cotsarelis’s work reached the public) should begin in the next few months. The trial has several phases, however, and Zohar cautions that final data won’t be in for at least a year. So don’t pull your hair out waiting for results.
<<<<<<<<<<<

http://www.hairsite.com/hair-loss/forum_entry-id-37521.html

I had completely forgotten this thread (where I myself participated).
Here Zohar clearly says 4/5 years for approval.
Its not clear what happens with the so-called “proof-of-concept” trial, nor what does it mean in the 3-phase trial schedule.

» In May 2007 cotsarelis said “2/3 years”, now “within 5 years”…He thinks
» only of himself … Our hopes are closes: we live our lives by bald!
»
» http://www.citypaper.net/articles/2009/01/22/george-cotsaleris-hair-follicle-research

He dropped a ten spot in this article.

Chopping off an amphibian’s arm is fairly inconsequential, considering a brand-new one can regenerate in three months. Now, research shows that a mouse’s hair follicles can do the same when its skin is wounded, sparking stem-cell-like machinery into action to produce fresh follicles.

The finding tears down 50-year-old dogma about mammals’ inability to regenerate hair-growing tissue, investigative dermatologists at the University of Pennsylvania School of Medicine said.

With scientific head-butting now aside, the researchers think doors to better hair loss treatments are little closer to opening.

Root of the problem

Hair follicles hang out in skin like the root of a weed, growing fresh hair when the hair itself is destroyed by your barber. But when a follicle is maimed by a cut, burn or other injury, it dies.

Thankfully, brand new hair follicles can grow in wounded skin — but how they do this has been misconceived until now, said George Cotsarelis, a co-author of the study detailed in today’s issue of Nature.

“Studies in the 50s determined hair follicles migrated from the edge of a wound,” Cotsarelis said. “But we think wounding induces a primitive, embryonic state in cells so they can be manipulated to produce hair follicles.”

Specifically, he said, a biological pathway called “Wnt” programs healing tissue to turn into hair follicles. When Cotsarelis and his colleagues super-charged Wnt pathways in mice and wounded their skin, double the normal follicles regenerated when the wound healed.

Hair-raising treatments?

Losing a head of hair can be vexing for men and some women, especially because drugs like minoxidil only help “wake up” dormant hair follicles. They do not create new ones.

Damaging large patches of skin isn’t an attractive option for those wanting help with growing hair, and no one is talking about that as a treatment approach. However, understanding the pathways that cause haair follicle regeneration could yield effective drugs.

“If we’re lucky, I think it’s possible we’ll have some new ways to treat hair loss and bad scars in five to 10 years,” Cotsarelis told LiveScience. “And not just the hair loss, but also thinning hair.”

As people age, hair follicles lose their ability to crank out thick hair and produce thin strands instead. Yet new follicles grow thicker hair than older ones, Cotsarelis said, “so if we can reproduce that effect with a drug it would be huge.”

Cheng-Ming Chuong, a tissue engineer also at the Penn School of Medicine but not connected with the study, thinks the work has more far-reaching implications than a man’s confidence about his mane. The finding that an adult mouse can regenerate any tissue, even tiny hair follicles, is a milestone, he explained.

“When amphibians regenerate a limb, they regenerate everything — it’s hard to tell anything was dismembered,” Chuong said, adding that mammals may have similar machinery in place.

Still, Chuong doesn’t expect losing an arm to become a problem of the past any time soon. “Although this discovery holds a lot of promise for regenerative medicine, we’re nowhere near growing new limbs yet,” he said.

thanks for the article. it is almost 2 year old. may 2007.
he said “5 to 10 years if we are lucky”.

» He dropped a ten spot in this article.
»
» Chopping off an amphibian’s arm is fairly inconsequential, considering a
» brand-new one can regenerate in three months. Now, research shows that a
» mouse’s hair follicles can do the same when its skin is wounded, sparking
» stem-cell-like machinery into action to produce fresh follicles.
»
» The finding tears down 50-year-old dogma about mammals’ inability to
» regenerate hair-growing tissue, investigative dermatologists at the
» University of Pennsylvania School of Medicine said.
»
» With scientific head-butting now aside, the researchers think doors to
» better hair loss treatments are little closer to opening.
»
» Root of the problem
»
» Hair follicles hang out in skin like the root of a weed, growing fresh
» hair when the hair itself is destroyed by your barber. But when a follicle
» is maimed by a cut, burn or other injury, it dies.
»
» Thankfully, brand new hair follicles can grow in wounded skin — but how
» they do this has been misconceived until now, said George Cotsarelis, a
» co-author of the study detailed in today’s issue of Nature.
»
» “Studies in the 50s determined hair follicles migrated from the edge of a
» wound,” Cotsarelis said. “But we think wounding induces a primitive,
» embryonic state in cells so they can be manipulated to produce hair
» follicles.”
»
» Specifically, he said, a biological pathway called “Wnt” programs healing
» tissue to turn into hair follicles. When Cotsarelis and his colleagues
» super-charged Wnt pathways in mice and wounded their skin, double the
» normal follicles regenerated when the wound healed.
»
» Hair-raising treatments?
»
» Losing a head of hair can be vexing for men and some women, especially
» because drugs like minoxidil only help “wake up” dormant hair follicles.
» They do not create new ones.
»
» Damaging large patches of skin isn’t an attractive option for those
» wanting help with growing hair, and no one is talking about that as a
» treatment approach. However, understanding the pathways that cause haair
» follicle regeneration could yield effective drugs.
»
» “If we’re lucky, I think it’s possible we’ll have some new ways to treat
» hair loss and bad scars in five to 10 years,” Cotsarelis told LiveScience.
» “And not just the hair loss, but also thinning hair.”
»
» As people age, hair follicles lose their ability to crank out thick hair
» and produce thin strands instead. Yet new follicles grow thicker hair than
» older ones, Cotsarelis said, “so if we can reproduce that effect with a
» drug it would be huge.”
»
» Cheng-Ming Chuong, a tissue engineer also at the Penn School of Medicine
» but not connected with the study, thinks the work has more far-reaching
» implications than a man’s confidence about his mane. The finding that an
» adult mouse can regenerate any tissue, even tiny hair follicles, is a
» milestone, he explained.
»
» “When amphibians regenerate a limb, they regenerate everything — it’s hard
» to tell anything was dismembered,” Chuong said, adding that mammals may
» have similar machinery in place.
»
» Still, Chuong doesn’t expect losing an arm to become a problem of the past
» any time soon. “Although this discovery holds a lot of promise for
» regenerative medicine, we’re nowhere near growing new limbs yet,” he said.

The paragraph before that one also says that nobody is seriously considering damaging a large area of scalp for hair regrowth, either. And that’s precisely what Folica testing right now.