Aderans Update* December 14, 2010

Stem cell; cell based hair therapy
1

http://www.prweb.com/releases/2010/12/prweb4896334.htm

Half of ARI Study Participants See Hair Growth After 1 Year in First Protocol

Aderans Research Institute (ARI) recently completed the first of seven protocols of a hair regeneration Phase 2 clinical study, and the results are in: more than half of study participants showed significant hair growth one year after the cell product treatment was administered.

Atlanta, GA (PRWEB) December 15, 2010

Aderans Research Institute (ARI) recently completed the first of seven protocols of a hair regeneration Phase 2 clinical study, and the results are in: more than half of study participants showed significant hair growth one year after the cell product treatment was administered.

“The results indicate that our scientific approach, our research and understanding of follicular cell and hair regeneration is headed in the right direction,” said Vern Liebmann, Vice President Operations. “The fact that an increase in hair growth is apparent as far out as one year after treatment indicates our process has staying power. Nobody we know of has produced results like these.”

Launched in November 2008, the current phase of the trial is open to select individuals who suffer from androgenetic alopecia. It is focused on finding the most promising cell product treatment from ARI’s Ji Gami™ family of unique cell products. The ongoing protocols are evaluating the additional variants in the family. ARI expects to have the one-year results from these protocols throughout 2011.

Two new protocols are scheduled to begin this month, and based on the results to date, they are expected to produce even greater benefits with continued durability of response of observed hair growth.

“We now have the building blocks for true cellular hair regeneration. We are excited by this knowledge and have great confidence in what is yet to come,” said Ken Washenik, M.D., Ph.D., Executive Vice President. “The successive protocols will evaluate products that, based on our research, hold even greater promise for cosmetically valued hair growth.”

For more information about the clinical trial, visit http://www.aderansresearch.com/ari_clinicupdates.html.

About Aderans Research

Aderans Research is a pioneer in the research and development of safe, effective cell engineered products for hair regeneration. With offices in Atlanta and Philadelphia, Aderans Research is a subsidiary of Unihair Co., Ltd, the world’s largest wig manufacturer, and affiliate of Bosley, a global leader in surgical hair restoration.

Ongoing information on ARI’s clinical study can be seen at http://www.aderansresearch.com/ari_clinicupdates.html

Additional information on ARI can be found at http://www.aderansresearch.com.

Learn more about ARI’s parent company Unihair Co., Ltd. at http://www.universal-hair.com/hd/english/index.html

Share:

Contact

* Vern Liebmann
  Aderans Research Institute
  678-213-1913
  Email

* Evan Judd
  Unihair Co., Ltd.
  +81-3-3350-3268
  Email
2

» http://www.prweb.com/releases/2010/12/prweb4896334.htm
»
»
» Half of ARI Study Participants See Hair Growth After 1 Year in First
» Protocol
»
» Aderans Research Institute (ARI) recently completed the first of seven
» protocols of a hair regeneration Phase 2 clinical study, and the results
» are in: more than half of study participants showed significant hair growth
» one year after the cell product treatment was administered.
»
»
» Atlanta, GA (PRWEB) December 15, 2010
»
» Aderans Research Institute (ARI) recently completed the first of seven
» protocols of a hair regeneration Phase 2 clinical study, and the results
» are in: more than half of study participants showed significant hair growth
» one year after the cell product treatment was administered.
»
» “The results indicate that our scientific approach, our research and
» understanding of follicular cell and hair regeneration is headed in the
» right direction,” said Vern Liebmann, Vice President Operations. “The fact
» that an increase in hair growth is apparent as far out as one year after
» treatment indicates our process has staying power. Nobody we know of has
» produced results like these.”
»
» Launched in November 2008, the current phase of the trial is open to
» select individuals who suffer from androgenetic alopecia. It is focused on
» finding the most promising cell product treatment from ARI’s Ji Gami™
» family of unique cell products. The ongoing protocols are evaluating the
» additional variants in the family. ARI expects to have the one-year results
» from these protocols throughout 2011.
»
» Two new protocols are scheduled to begin this month, and based on the
» results to date, they are expected to produce even greater benefits with
» continued durability of response of observed hair growth.
»
» “We now have the building blocks for true cellular hair regeneration. We
» are excited by this knowledge and have great confidence in what is yet to
» come,” said Ken Washenik, M.D., Ph.D., Executive Vice President. “The
» successive protocols will evaluate products that, based on our research,
» hold even greater promise for cosmetically valued hair growth.”
»
» For more information about the clinical trial, visit
» http://www.aderansresearch.com/ari_clinicupdates.html.
»
» About Aderans Research
»
» Aderans Research is a pioneer in the research and development of safe,
» effective cell engineered products for hair regeneration. With offices in
» Atlanta and Philadelphia, Aderans Research is a subsidiary of Unihair Co.,
» Ltd, the world’s largest wig manufacturer, and affiliate of Bosley, a
» global leader in surgical hair restoration.
»
» Ongoing information on ARI’s clinical study can be seen at
» http://www.aderansresearch.com/ari_clinicupdates.html
»
» Additional information on ARI can be found at
» http://www.aderansresearch.com.
»
» Learn more about ARI’s parent company Unihair Co., Ltd. at
» http://www.universal-hair.com/hd/english/index.html
»
» ###
» Share:
»
» Contact
»
» * Vern Liebmann
» Aderans Research Institute
» 678-213-1913
» Email
»
» * Evan Judd
» Unihair Co., Ltd.
» +81-3-3350-3268
» Email

Dont understand why people are so excited about this product? First protocol done out of seven? Is that an indication of that they know what they are doing? And it took 2 years to collect one year data on the first of seven protocols. Phase 2 will take forever.
And 50% resulted in significant hair growth? So half of the group had hair growth that wasnt coincidental. Not a word on how much hair or the quality of the hair.

They obviously dont know how to make it work after 8 years of research. This will never see the light of day.

3

» Dont understand why people are so excited about this product? First
» protocol done out of seven? Is that an indication of that they know what
» they are doing? And it took 2 years to collect one year data on the first
» of seven protocols. Phase 2 will take forever.
» And 50% resulted in significant hair growth? So half of the group had hair
» growth that wasnt coincidental. Not a word on how much hair or the quality
» of the hair.
»
» They obviously dont know how to make it work after 8 years of research.
» This will never see the light of day.

To each their own. I consider this good news, and I welcome the update.
I wish Follica could do the same.

4

» » http://www.prweb.com/releases/2010/12/prweb4896334.htm
» »
» »
» » Half of ARI Study Participants See Hair Growth After 1 Year in First
» » Protocol
» »
» » Aderans Research Institute (ARI) recently completed the first of seven
» » protocols of a hair regeneration Phase 2 clinical study, and the
» results
» » are in: more than half of study participants showed significant hair
» growth
» » one year after the cell product treatment was administered.
» »
» »
» » Atlanta, GA (PRWEB) December 15, 2010
» »
» » Aderans Research Institute (ARI) recently completed the first of seven
» » protocols of a hair regeneration Phase 2 clinical study, and the
» results
» » are in: more than half of study participants showed significant hair
» growth
» » one year after the cell product treatment was administered.
» »
» » “The results indicate that our scientific approach, our research and
» » understanding of follicular cell and hair regeneration is headed in the
» » right direction,” said Vern Liebmann, Vice President Operations. “The
» fact
» » that an increase in hair growth is apparent as far out as one year
» after
» » treatment indicates our process has staying power. Nobody we know of
» has
» » produced results like these.”
» »
» » Launched in November 2008, the current phase of the trial is open to
» » select individuals who suffer from androgenetic alopecia. It is focused
» on
» » finding the most promising cell product treatment from ARI’s Ji Gami™
» » family of unique cell products. The ongoing protocols are evaluating
» the
» » additional variants in the family. ARI expects to have the one-year
» results
» » from these protocols throughout 2011.
» »
» » Two new protocols are scheduled to begin this month, and based on the
» » results to date, they are expected to produce even greater benefits
» with
» » continued durability of response of observed hair growth.
» »
» » “We now have the building blocks for true cellular hair regeneration.
» We
» » are excited by this knowledge and have great confidence in what is yet
» to
» » come,” said Ken Washenik, M.D., Ph.D., Executive Vice President. “The
» » successive protocols will evaluate products that, based on our
» research,
» » hold even greater promise for cosmetically valued hair growth.”
» »
» » For more information about the clinical trial, visit
» » http://www.aderansresearch.com/ari_clinicupdates.html.
» »
» » About Aderans Research
» »
» » Aderans Research is a pioneer in the research and development of safe,
» » effective cell engineered products for hair regeneration. With offices
» in
» » Atlanta and Philadelphia, Aderans Research is a subsidiary of Unihair
» Co.,
» » Ltd, the world’s largest wig manufacturer, and affiliate of Bosley, a
» » global leader in surgical hair restoration.
» »
» » Ongoing information on ARI’s clinical study can be seen at
» » http://www.aderansresearch.com/ari_clinicupdates.html
» »
» » Additional information on ARI can be found at
» » http://www.aderansresearch.com.
» »
» » Learn more about ARI’s parent company Unihair Co., Ltd. at
» » http://www.universal-hair.com/hd/english/index.html
» »
» » ###
» » Share:
» »
» » Contact
» »
» » * Vern Liebmann
» » Aderans Research Institute
» » 678-213-1913
» » Email
» »
» » * Evan Judd
» » Unihair Co., Ltd.
» » +81-3-3350-3268
» » Email
»
» Dont understand why people are so excited about this product? First
» protocol done out of seven? Is that an indication of that they know what
» they are doing? And it took 2 years to collect one year data on the first
» of seven protocols. Phase 2 will take forever.
» And 50% resulted in significant hair growth? So half of the group had hair
» growth that wasnt coincidental. Not a word on how much hair or the quality
» of the hair.
»
» They obviously dont know how to make it work after 8 years of research.
» This will never see the light of day.

I agree with you for the most part. I do agree with you that these results are nothing to get excited about but I I’m not so sure that Aderans will never come to market. My reason for thinking that this update does not give any exciting news is that they reported that a mere 50% of subjects grew signficant hair. The percentage of subjects that grew new hair is a low percentage and the amount of hair they regrew is not enough. Keep in mind that finasteride grows “significantly” more hair in about half of patients too, and minoxidil also has similar results to Aderans. Since both Finasteride and minoxidil have similar results to Aderans, and both of them are in the marketplace, that proves that Aderans may also make it into the marketplace.

Also, Aderans may improve on the percentages of subjects that grow hair and Aderans may also improve on the amount of hair regrown, but the jury is still out on those two issues.

In any case, you might be right that Aderans may never come to market because Aderans is taking a long, long time to progress, and by the time they get the bugs worked out, if they ever do get the bugs worked out, there may be other products on the market that produce better results and if that is the case then the financial backers of Aderans may stop funding the Aderans project and Aderans may stop progressing altogether.

5

more than 50% of people growing hair for the first (and old) trial is not bad, you have to consider that the best is yet to come 'cause they have many protocols to try and they KNOW how to improve this procedure, the real phase 2 is going to start by now till the end of 2011 (and some months later but since that date we’ll have enough informations to see if there are chance to hit the market or not)

in the next year we’ll see the REAL improvement of aderans and what they can do

for now we’ve nothing better to do than wait

the same for Histogen, I guess and imagine 2011 as the year we’ll REALLY can understand if those HM procedure are going to work or not, we just need to be patient a little bit

6

can’t they test these protocols in rats or something to speed up the process ?

the most efficient protocol will be discovered a lot quicker.

i’m not impressed with the results. just 50%.

some before & after pictures could tell us the full story.

7

Does that mean the new hairs continue to grow 1 year after only 1 treatment?

8

» http://www.prweb.com/releases/2010/12/prweb4896334.htm
»
»
» Half of ARI Study Participants See Hair Growth After 1 Year in First
» Protocol
»
» Aderans Research Institute (ARI) recently completed the first of seven
» protocols of a hair regeneration Phase 2 clinical study, and the results
» are in: more than half of study participants showed significant hair growth
» one year after the cell product treatment was administered.
»
»
» Atlanta, GA (PRWEB) December 15, 2010
»
» Aderans Research Institute (ARI) recently completed the first of seven
» protocols of a hair regeneration Phase 2 clinical study, and the results
» are in: more than half of study participants showed significant hair growth
» one year after the cell product treatment was administered.
»
» “The results indicate that our scientific approach, our research and
» understanding of follicular cell and hair regeneration is headed in the
» right direction,” said Vern Liebmann, Vice President Operations. “The fact
» that an increase in hair growth is apparent as far out as one year after
» treatment indicates our process has staying power. Nobody we know of has
» produced results like these.”

It seems you do not (want to?) know a lot, Mr. Liebmann …

http://www.bloomberg.com/apps/news?pid=newsarchive&sid=a6OdEa5VFNV8

IN SHORT:
The study — conducted by Marwa Fawzi, a dermatologist at the University of Cairo Faculty of Medicine, used stem cells from the scalps of eight children with alopecia areata to regenerate their own hair:

The Cairo researcher took small amounts of skin from the scalps of the children,

  • isolated the hair follicle stem cells that stimulate hair production, and
  • grew them in the lab,
  • increasing the number of cells.

After one month, she put the cells back into the scalps of the children, with numerous injections across the bald areas of their heads.

Six months after the hair cloning treatment, an evaluation showed

  • a 50% increase in hair in more than half of the subjects.

Dr. Fawzi took new skin samples and examined the hair follicles themselves and could see that the

  • injected stem cells had migrated into the follicles. There, the stem cells stimulated the follicles to transition from a dormant phase to a hair-generating phase.

So, that means, if somebody don’t have any “dormant” hair follicles in the scalp anymore = no hairs … :expressionless:

9

» So, that means, if somebody don’t have any “dormant” hair follicles in the
» scalp anymore = no hairs … :expressionless:

I’ve never seen any solid case where a person who was bald for years spontaneously regrew his hair due to some accident or anything else. I have seen one or two letters published by doctors in some medical journal regarding one guy who grew more hair after taking something - forgot what it was I think immune-supression drugs.

But the fact that in 2000 years, we have not heard of a bald guy who went to norwood 1 due to some wierd chemical reaction or drug suggests to me that once the follicle has miniturized and died, its gone forever. Its not coming back from the grave - at least not for androgenic alopecia.

Alopecia areata however might be different. Maybe the follicles are still alive but in a dormant (resting) phase?

All this highlights one thing - its better to treat your hairloss and keep the hair you have sooner rather than later. The window of opportunity is small once you detect you have MPB.

Another thing I notice : I’ve not heard of anyone going bald after taking legitimate propecia (not generic) or avodart (brand name) from the point he first learnt he had mpb. To me this suggest you can keep your hair or severely slow down MPB if only you get on the drug at the start.

10

» » So, that means, if somebody don’t have any “dormant” hair follicles in
» the
» » scalp anymore = no hairs … :expressionless:
»
» I’ve never seen any solid case where a person who was bald for years
» spontaneously regrew his hair due to some accident or anything else. I
» have seen one or two letters published by doctors in some medical journal
» regarding one guy who grew more hair after taking something - forgot what
» it was I think immune-supression drugs.

Its because there aren’t any proper treatments, rather than the case of a dead follicle. The follicle minitaurizes to the point its producing very fine, small, colorless hair - like on most woman’s bodies. However, the follicle is still there. I’m a NW7 and I can still see dense vellus hair all over my scalp, under proper lightning. So I know the follicles aren’t dead, even though I look slick bald to everyone.

Also, there was a study done in which they took minitaurized hair from bald scalp and implanted it on immuno-suppressed mice, and it grew back a terminal hair. Ironically, it grew back thicker than the terminal hair they implanted on the mouse - from same patient. So we know that the body does something that causes the follicle to stay in minitaurized state, its not really dead.

My guess is that the body is actively targeting the dermal papilla cells, in the hair bulb, thus ceasing its growth potential.

11

» My guess is that the body is actively targeting the dermal papilla
» cells, in the hair bulb, thus ceasing its growth potential.

Cool - because ARI is actively targeting the dermal papilla since more than 8 years. So be prepared guys, because in a few days, you will have access to hair multiplication technology.
Good luck! :slight_smile:

2879_image63.jpg816×535

12

In a few DAYS?

Um, Ironman, what are you smoking?

As for the fact that we haven’t seen regrowth from anything so far, I think that just demonstrates that we shouldn’t hope for any substance/method that’s not artificially manmade and recent. If there was a natural way to help us then mankind would have stumbled onto it by now.

13

» In a few DAYS?
»
» Um, Ironman, what are you smoking?
»
»
»
» As for the fact that we haven’t seen regrowth from anything so far, I
» think that just demonstrates that we shouldn’t hope for any
» substance/method that’s not artificially manmade and recent. If there was
» a natural way to help us then mankind would have stumbled onto it by now.

i disagree… histogen shows promising regrowth results.

14

» In a few DAYS?
»
» Um, Ironman, what are you smoking?

Why? The currently running (1st) decade of the 21st century ends in a few days – right?
So ARI is clearly saying (see website screenshot above) “that before the end of this decade patients will have access to HM”. Can’t you read?? What do YOU smoke? :expressionless:

15

this screenshot is old (half year or even more?) and you know that :slight_smile:

» » In a few DAYS?
» »
» » Um, Ironman, what are you smoking?
»
» Why? The currently running (1st) decade of the 21st century ends in a few
» days – right?
» So ARI is clearly saying (see website screenshot above) “that
» before the end of this decade patients will have access to HM”. Can’t you
» read?? What do YOU smoke? :expressionless:

16

» » In a few DAYS?
» »
» » Um, Ironman, what are you smoking?
»
» Why? The currently running (1st) decade of the 21st century ends in a few
» days – right?
» So ARI is clearly saying (see website screenshot above) “that
» before the end of this decade patients will have access to HM”. Can’t you
» read?? What do YOU smoke? :expressionless:

stop kidding us ! u know and we knows as well this is (or was? I didn’t saw the website recently) a page not updated by aderans…

17

» stop kidding us ! u know and we knows as well this is (or was? I didn’t
» saw the website recently) a page not updated by aderans…

Oh … and what does now the update say? And for what an “update” at all??

18

you know aderans is going for test until the end of 2012 at least

ps. however I can’t find that page on aderans website, that picture should be really old

19

» ps. however I can’t find that page on aderans website, that picture should
» be really old

That doesn’t matter. ARI clearly stated “by the end of this decade”. And this decade ends in 2 days. So, does that mean they fooled me and I can’t get a full head of hair in 2 days?? :confused:

If not, why do they treat me like a fool??

20

» As for the fact that we haven’t seen regrowth from anything so far, I
» think that just demonstrates that we shouldn’t hope for any
» substance/method that’s not artificially manmade and recent. If there was
» a natural way to help us then mankind would have stumbled onto it by now.

» i disagree… histogen shows promising regrowth results.

We don’t really disagree. Histogen falls under what I would call “unnatural” substances & methods.

IMO nothing that was theoretically available to mankind 100 years ago is going to work. Probably nothing available even 20-30 years ago. The cure may perfectly well be around the corner right now, but in that case it probably wasn’t possible until recently.