http://www.aderansresearch.com/ari_jobs.html
That’s quite a number of positions. The “Research Scientist” position requires experience with “surgical lasers in skin and hair”.
» http://www.aderansresearch.com/ari_jobs.html
»
» That’s quite a number of positions. The “Research Scientist” position
» requires experience with “surgical lasers in skin and hair”.
surgical lasers? does this mean dermabrasion? (Histogen is using laser to dermabrade.)
what other thing could they be doing with lasers?
it is surprising, because most probably, ARI’s method is based on scaffolds, and thus I don’t see the point on dermabrading the scalp. Maybe the laser creates the hole for the scaffold?
» » http://www.aderansresearch.com/ari_jobs.html
» »
» » That’s quite a number of positions. The “Research Scientist” position
» » requires experience with “surgical lasers in skin and hair”.
»
» surgical lasers? does this mean dermabrasion? (Histogen is using laser to
» dermabrade.)
» what other thing could they be doing with lasers?
»
» it is surprising, because most probably, ARI’s method is based on
» scaffolds, and thus I don’t see the point on dermabrading the scalp. Maybe
» the laser creates the hole for the scaffold?
The description says:
“Research interaction mechanisms between laser and skin tissue to enable hair growth and transplantation”
» » » http://www.aderansresearch.com/ari_jobs.html
» » »
» » » That’s quite a number of positions. The “Research Scientist”
» position
» » » requires experience with “surgical lasers in skin and hair”.
» »
» » surgical lasers? does this mean dermabrasion? (Histogen is using laser
» to
» » dermabrade.)
» » what other thing could they be doing with lasers?
» »
» » it is surprising, because most probably, ARI’s method is based on
» » scaffolds, and thus I don’t see the point on dermabrading the scalp.
» Maybe
» » the laser creates the hole for the scaffold?
»
» The description says:
»
» “Research interaction mechanisms between laser and skin tissue to enable
» hair growth and transplantation”
Transplantation??? All I know about Aderans doesn’t involve any kind of transplantation of hair. If they are asking now for this type of employer (and not before), I don’t think they need it for the actual trial they are doing, but I can be mistaken…
» » » » http://www.aderansresearch.com/ari_jobs.html
» » » »
» » » » That’s quite a number of positions. The “Research Scientist”
» » position
» » » » requires experience with “surgical lasers in skin and hair”.
» » »
» » » surgical lasers? does this mean dermabrasion? (Histogen is using
» laser
» » to
» » » dermabrade.)
» » » what other thing could they be doing with lasers?
» » »
» » » it is surprising, because most probably, ARI’s method is based on
» » » scaffolds, and thus I don’t see the point on dermabrading the scalp.
» » Maybe
» » » the laser creates the hole for the scaffold?
» »
» » The description says:
» »
» » “Research interaction mechanisms between laser and skin tissue to
» enable
» » hair growth and transplantation”
»
» Transplantation??? All I know about Aderans doesn’t involve any kind of
» transplantation of hair. If they are asking now for this type of employer
» (and not before), I don’t think they need it for the actual trial they are
» doing, but I can be mistaken…
I thought Aderan’s protocol involved transplantation. They’d culture hair, then implant it. It is, after all, owned by Bosely.
They plant a cell-soaked scaffold into the scalp.
Maybe they will use the laser, to see if growth is improved.
» » » » http://www.aderansresearch.com/ari_jobs.html
» » » » »
» » » » » That’s quite a number of positions. The “Research Scientist”
» » » position
» » » » » requires experience with “surgical lasers in skin and hair”.
» » » »
» » » » surgical lasers? does this mean dermabrasion? (Histogen is using
» » laser
» » » to
» » » » dermabrade.)
» » » » what other thing could they be doing with lasers?
» » » »
» » » » it is surprising, because most probably, ARI’s method is based on
» » » » scaffolds, and thus I don’t see the point on dermabrading the
» scalp.
» » » Maybe
» » » » the laser creates the hole for the scaffold?
» » »
» » » The description says:
» » »
» » » “Research interaction mechanisms between laser and skin tissue to
» » enable
» » » hair growth and transplantation”
» »
» » Transplantation??? All I know about Aderans doesn’t involve any kind of
» » transplantation of hair. If they are asking now for this type of
» employer
» » (and not before), I don’t think they need it for the actual trial they
» are
» » doing, but I can be mistaken…
»
» I thought Aderan’s protocol involved transplantation. They’d culture
» hair, then implant it. It is, after all, owned by Bosely.
» They plant a cell-soaked scaffold into the scalp.
»
» Maybe they will use the laser, to see if growth is improved.
»
»
» » » » » http://www.aderansresearch.com/ari_jobs.html
» » » » » »
» » » » » » That’s quite a number of positions. The “Research Scientist”
» » » » position
» » » » » » requires experience with “surgical lasers in skin and hair”.
» » » » »
» » » » » surgical lasers? does this mean dermabrasion? (Histogen is using
» » » laser
» » » » to
» » » » » dermabrade.)
» » » » » what other thing could they be doing with lasers?
» » » » »
» » » » » it is surprising, because most probably, ARI’s method is based on
» » » » » scaffolds, and thus I don’t see the point on dermabrading the
» » scalp.
» » » » Maybe
» » » » » the laser creates the hole for the scaffold?
» » » »
» » » » The description says:
» » » »
» » » » “Research interaction mechanisms between laser and skin tissue to
» » » enable
» » » » hair growth and transplantation”
» » »
» » » Transplantation??? All I know about Aderans doesn’t involve any kind
» of
» » » transplantation of hair. If they are asking now for this type of
» » employer
» » » (and not before), I don’t think they need it for the actual trial
» they
» » are
» » » doing, but I can be mistaken…
» »
» » I thought Aderan’s protocol involved transplantation. They’d culture
» » hair, then implant it. It is, after all, owned by Bosely.
Aderans seeks to implant cultered cells at various levels within the dermis. They are attempting to create precisely dimensioned cavities with an erbium-YAG laser.
http://www.aderansresearch.com/pdfs/PUBLICATION_ARI_Ab_HH07.pdf
This is very interesting. They are using little pigs, instead of mice. Pig skin is more like human skin. The results on pig are totally different than in mice. Read at the end.
But note that this document is from March 2007.
COPY:
Hair Follicle Neogenesis in the Adult Pig by Implantation of Trichogenic Cells Obtained from Neonatal Pig Skin
Y. Su, B. Marshall, S. Cochran, R. Lorenz1, S. Parimoo,
L. Herron2, T. Barrows, and K. Stenn
Aderans Research Institute
1Bosley
2ATDC, Georgia Tech
ABSTRACT:
Surgical hair restoration as a cosmetic procedure for baldness is limited by the supply of donor site follicles that can be excised and re-implanted to create the illusion of a fuller head of hair. Tissue engineering offers the possibility of hair multiplication by creating follicle-inducing implants from cells harvested from follicles and expanded in culture. We previously reported follicle neogenesis of mouse hair upon subcutaneous injection of dissociated cells obtained from newborn mouse skin into the athymic nude mouse. The goal of the present study was to continue investigation of the follicle neogenesis process in a large animal model affording skin that is anatomically similar to that of the human.
Materials & Methods:
Purpose bred Sinclair miniature swine were used as subjects under an IACUC approved protocol in compliance with current guidelines. All procedures were conducted using aseptic surgical technique with animals under general anesthesia. Neonatal same-breed skin was obtained and freshly processed by a method similar to that previously described for isolation of dermal and epidermal cells from neonatal mouse skin. Since pig skin, like human skin, is at least 10 times thicker than mouse skin, we sought to implant cells at various levels within the dermis including the fat-dermis interface. This was accomplished by creating precisely dimensioned cavities with an erbium-YAG laser. Cells were combined with Matrigel™ (a surrogate extracellular matrix) and implanted at various depths. As a control, traditional surgical hair transplantation was performed. Routine histological evaluation of biopsy specimens was conducted. In one case, a female adult pig was implanted with male neonatal cells and the resultant implant site evaluated for the presence of hair follicle structures containing male cells via FISH analysis using a y-chromosome specific probe.
Results & Conclusions:
New hair follicles were detected as early as 30 days post-implantation and formed most successfully when the cells were implanted at the level of the fat-dermis interface. In replicate studies, hair follicles formed in 8 out of 18 and in 19 out of 48 implantations. Unlike mouse follicle neogenesis from dissociated cells, which yielded dozens of individual but randomly oriented follicles per injection, the pig cells only formed a single follicle at each implant site. The detection of y-chromosome positive cells in the case where male cells were implanted in the female pig confirmed that the formed follicle contained the implanted cells. These follicles invariably produced ingrown hair shafts. However, this may be endemic to this host system since a surprising rate of ingrown hair was also observed with whole follicle transplantation. We believe this to be the first demonstration of hair follicle neogenesis in the pig by implantation of cells.
Eleventh Annual Hilton Head
Workshop - Tissue Engineering & Regenerative Medicine
March 7-11, 2007
<<<<<<<<<
» » They plant a cell-soaked scaffold into the scalp.
» »
» » Maybe they will use the laser, to see if growth is improved.
» »
» »
» » » » » » http://www.aderansresearch.com/ari_jobs.html
» » » » » » »
» » » » » » » That’s quite a number of positions. The “Research Scientist”
» » » » » position
» » » » » » » requires experience with “surgical lasers in skin and hair”.
» » » » » »
» » » » » » surgical lasers? does this mean dermabrasion? (Histogen is
» using
» » » » laser
» » » » » to
» » » » » » dermabrade.)
» » » » » » what other thing could they be doing with lasers?
» » » » » »
» » » » » » it is surprising, because most probably, ARI’s method is based
» on
» » » » » » scaffolds, and thus I don’t see the point on dermabrading the
» » » scalp.
» » » » » Maybe
» » » » » » the laser creates the hole for the scaffold?
» » » » »
» » » » » The description says:
» » » » »
» » » » » “Research interaction mechanisms between laser and skin tissue to
» » » » enable
» » » » » hair growth and transplantation”
» » » »
» » » » Transplantation??? All I know about Aderans doesn’t involve any
» kind
» » of
» » » » transplantation of hair. If they are asking now for this type of
» » » employer
» » » » (and not before), I don’t think they need it for the actual trial
» » they
» » » are
» » » » doing, but I can be mistaken…
» » »
» » » I thought Aderan’s protocol involved transplantation. They’d culture
» » » hair, then implant it. It is, after all, owned by Bosely.
»
»
» Aderans seeks to implant cultered cells at various levels within the
» dermis. They are attempting to create precisely dimensioned cavities with
» an erbium-YAG laser.
»
» http://www.aderansresearch.com/pdfs/PUBLICATION_ARI_Ab_HH07.pdf
» This is very interesting. They are using little pigs, instead of mice. Pig
» skin is more like human skin. The results on pig are totally different than
» in mice. Read at the end.
» But note that this document is from March 2007.
»
» COPY:
» >>>>>>
» Hair Follicle Neogenesis in the Adult Pig by Implantation of Trichogenic
» Cells Obtained from Neonatal Pig Skin
» Y. Su, B. Marshall, S. Cochran, R. Lorenz1, S. Parimoo,
» L. Herron2, T. Barrows, and K. Stenn
» Aderans Research Institute
» 1Bosley
» 2ATDC, Georgia Tech
» ABSTRACT:
» Surgical hair restoration as a cosmetic procedure for baldness is limited
» by the supply of donor site follicles that can be excised and re-implanted
» to create the illusion of a fuller head of hair. Tissue engineering offers
» the possibility of hair multiplication by creating follicle-inducing
» implants from cells harvested from follicles and expanded in culture. We
» previously reported follicle neogenesis of mouse hair upon subcutaneous
» injection of dissociated cells obtained from newborn mouse skin into the
» athymic nude mouse. The goal of the present study was to continue
» investigation of the follicle neogenesis process in a large animal model
» affording skin that is anatomically similar to that of the human.
» Materials & Methods:
» Purpose bred Sinclair miniature swine were used as subjects under an IACUC
» approved protocol in compliance with current guidelines. All procedures
» were conducted using aseptic surgical technique with animals under general
» anesthesia. Neonatal same-breed skin was obtained and freshly processed by
» a method similar to that previously described for isolation of dermal and
» epidermal cells from neonatal mouse skin. Since pig skin, like human skin,
» is at least 10 times thicker than mouse skin, we sought to implant cells at
» various levels within the dermis including the fat-dermis interface. This
» was accomplished by creating precisely dimensioned cavities with an
» erbium-YAG laser. Cells were combined with Matrigel™ (a surrogate
» extracellular matrix) and implanted at various depths. As a control,
» traditional surgical hair transplantation was performed. Routine
» histological evaluation of biopsy specimens was conducted. In one case, a
» female adult pig was implanted with male neonatal cells and the resultant
» implant site evaluated for the presence of hair follicle structures
» containing male cells via FISH analysis using a y-chromosome specific
» probe.
» Results & Conclusions:
» New hair follicles were detected as early as 30 days post-implantation and
» formed most successfully when the cells were implanted at the level of the
» fat-dermis interface. In replicate studies, hair follicles formed in 8 out
» of 18 and in 19 out of 48 implantations. Unlike mouse follicle neogenesis
» from dissociated cells, which yielded dozens of individual but randomly
» oriented follicles per injection, the pig cells only formed a single
» follicle at each implant site. The detection of y-chromosome positive cells
» in the case where male cells were implanted in the female pig confirmed
» that the formed follicle contained the implanted cells. These follicles
» invariably produced ingrown hair shafts. However, this may be endemic to
» this host system since a surprising rate of ingrown hair was also observed
» with whole follicle transplantation. We believe this to be the first
» demonstration of hair follicle neogenesis in the pig by implantation of
» cells.
» Eleventh Annual Hilton Head
» Workshop - Tissue Engineering & Regenerative Medicine
» March 7-11, 2007
» <<<<<<<<<
»
» » » They plant a cell-soaked scaffold into the scalp.
» » »
» » » Maybe they will use the laser, to see if growth is improved.
» » »
» » »
» » » » » » » http://www.aderansresearch.com/ari_jobs.html
» » » » » » » »
» » » » » » » » That’s quite a number of positions. The “Research
» Scientist”
» » » » » » position
» » » » » » » » requires experience with “surgical lasers in skin and
» hair”.
» » » » » » »
» » » » » » » surgical lasers? does this mean dermabrasion? (Histogen is
» » using
» » » » » laser
» » » » » » to
» » » » » » » dermabrade.)
» » » » » » » what other thing could they be doing with lasers?
» » » » » » »
» » » » » » » it is surprising, because most probably, ARI’s method is
» based
» » on
» » » » » » » scaffolds, and thus I don’t see the point on dermabrading the
» » » » scalp.
» » » » » » Maybe
» » » » » » » the laser creates the hole for the scaffold?
» » » » » »
» » » » » » The description says:
» » » » » »
» » » » » » “Research interaction mechanisms between laser and skin tissue
» to
» » » » » enable
» » » » » » hair growth and transplantation”
» » » » »
» » » » » Transplantation??? All I know about Aderans doesn’t involve any
» » kind
» » » of
» » » » » transplantation of hair. If they are asking now for this type of
» » » » employer
» » » » » (and not before), I don’t think they need it for the actual trial
» » » they
» » » » are
» » » » » doing, but I can be mistaken…
» » » »
» » » » I thought Aderan’s protocol involved transplantation. They’d
» culture
» » » » hair, then implant it. It is, after all, owned by Bosely.
» »
» »
» » Aderans seeks to implant cultered cells at various levels within the
» » dermis. They are attempting to create precisely dimensioned cavities
» with
» » an erbium-YAG laser.
» »
» » http://www.aderansresearch.com/pdfs/PUBLICATION_ARI_Ab_HH07.pdf
I forgot to thank you for the find, Minitor.
So, now we know that they are going to use the laser to create these cavities…
does this mean NO SCAFFOLDS??
» » They plant a cell-soaked scaffold into the scalp.
» »
» » Maybe they will use the laser, to see if growth is improved.
» »
» »
» » » » » » http://www.aderansresearch.com/ari_jobs.html
» » » » » » »
» » » » » » » That’s quite a number of positions. The “Research Scientist”
» » » » » position
» » » » » » » requires experience with “surgical lasers in skin and hair”.
» » » » » »
» » » » » » surgical lasers? does this mean dermabrasion? (Histogen is
» using
» » » » laser
» » » » » to
» » » » » » dermabrade.)
» » » » » » what other thing could they be doing with lasers?
» » » » » »
» » » » » » it is surprising, because most probably, ARI’s method is based
» on
» » » » » » scaffolds, and thus I don’t see the point on dermabrading the
» » » scalp.
» » » » » Maybe
» » » » » » the laser creates the hole for the scaffold?
» » » » »
» » » » » The description says:
» » » » »
» » » » » “Research interaction mechanisms between laser and skin tissue to
» » » » enable
» » » » » hair growth and transplantation”
» » » »
» » » » Transplantation??? All I know about Aderans doesn’t involve any
» kind
» » of
» » » » transplantation of hair. If they are asking now for this type of
» » » employer
» » » » (and not before), I don’t think they need it for the actual trial
» » they
» » » are
» » » » doing, but I can be mistaken…
» » »
» » » I thought Aderan’s protocol involved transplantation. They’d culture
» » » hair, then implant it. It is, after all, owned by Bosely.
»
»
» Aderans seeks to implant cultered cells at various levels within the
» dermis. They are attempting to create precisely dimensioned cavities with
» an erbium-YAG laser.
»
» http://www.aderansresearch.com/pdfs/PUBLICATION_ARI_Ab_HH07.pdf
Don’t know if the cavities mean no scaffolds – the cavities may be the place where they are putting the scaffolds.
In any event, I may call Aderans’ number in DC soon to volunteer to be a trialist, or at least get more information.
» Don’t know if the cavities mean no scaffolds – the cavities may be the
» place where they are putting the scaffolds.
But it seems that they used laser but no scaffolds in the pig experiments. They used Matrigel ECM, combined with cells.
This was accomplished by creating precisely dimensioned cavities with an erbium-YAG laser. Cells were combined with Matrigel™ (a surrogate extracellular matrix) and implanted at various depths. <<
So, it seems that they are using a gel matrix as scaffold, instead of a polymer scaffold. Very interesting.
In fact, the resulting hairs were ingrown in the pig, so this would further indicate that there was no scaffold.
But ant the same time, surprisingly, whole hair bulbs were transplanted into the pig, and these evolved into ingrown hairs too!!
»
» In any event, I may call Aderans’ number in DC soon to volunteer to be a
» trialist, or at least get more information.
Great!
» » Don’t know if the cavities mean no scaffolds – the cavities may be the
» » place where they are putting the scaffolds.
»
»
Polymer Scaffolds, Laser Cavities. Doesn’t this seem like invasive surgery or painful procedures. This is not a natural way for a hair to grow and I question whether this is the right approach.
» » » Don’t know if the cavities mean no scaffolds – the cavities may be
» the
» » » place where they are putting the scaffolds.
» »
» »
»
» Polymer Scaffolds, Laser Cavities. Doesn’t this seem like invasive surgery
» or painful procedures. This is not a natural way for a hair to grow and I
» question whether this is the right approach.
the scaffolds are very small rods of biodegradable porous plastic.
and the laser cavities are very small wounds but done more precisely with the laser.
Doesn’t look too invasive to me.
» » » Don’t know if the cavities mean no scaffolds – the cavities may be
» the
» » » place where they are putting the scaffolds.
» » ----------
» Polymer Scaffolds, Laser Cavities. Doesn’t this seem like invasive surgery
» or painful procedures. This is not a natural way for a hair to grow and I
» question whether this is the right approach.
Correct. So I think the legitimate question is, which procedure is (will be) more predictable and more (cost) EFFECTIVE in general, especially in the long run? The other question is, which apporach is more “natural”?
ARI’s “just cell based” in vitro HM approach or Dr. Gho’s HST in vivo HM approach?
A HSI patient (kees55) posted the following donor photos 10
month ago on a Dutch hair loss board:
Donor area 6 days after extraction …
Donor area 13 days after extraction …
Click on the photos to enlarge them – and you can
CLEARLY see what happened (extraction) and what’s going on in a donor area
during the first 2 weeks after a HST procedure.
Actually, it doesn’t really matter what exactly serves as laboratory for multiplying the follicle cells: 1) a real laboratory or 2) the “natural in vivo laboratory” on the back of your head.
Anyway, in theory (at least according to both parties), with BOTH approaches you can get hair as much as you want – that’s their declared aim.
p.s. - I know that this thread is old …
This depends on how both partys gonna redefine their stuff.
If gho could use a robot device which fits his thing and guarantees the same amount of regrowth and a higher density of 80 grafts and above, well Ari will have a hard time.
Or are you speaking aout Ghos HSI and not HST here? Those are some sort same but different approaches. I think the later (HSI) is more something like What Ari or Histogen does, but instead of jumbling around he injects the “solid material directly”
With this approach you can very well indeed achieve the highest density possible and ever achievable.
» Or are you speaking aout Ghos HSI and not HST here? Those are some sort
» same but different approaches. I think the later (HSI) is more something
» like What Ari or Histogen does, but instead of jumbling around he injects
» the “solid material directly”
So what is it Iron.Man or are you not sure anymore baout Gho. I mean you somewhere also admit that he doesnt give the perfect hairline or someting like that.
So what is it oh and before i forget about it, how many Grafts will you get this year from Gho?
» Polymer Scaffolds, Laser Cavities. Doesn’t this seem like invasive surgery
» or painful procedures. This is not a natural way for a hair to grow and
» I question whether this is the right approach.
Here is a video where Dr. Ken Washenik presented ARI’s approach in front of his boss & investors (11 month ago):
http://www.aderansresearch.com/presentation/
Let’s assume YOU are an interested investor or even Washenik’s boss. Can Dr. Washinik convince you with “here a hair and there a hair”, resp. in general?
That’s just a question …
