» » Hello TAGHOL,
» » Hope you are doing fine and that your experimentation is going well.
» » I’ve a question for you : do you know,through your lecture of the
» » paper and the patent, if the WNT supression at first might enhance,
» » on, the activity of WNT pathways (coupling this with a WNT agonist
» » an antagonist for a certain lapse of time).
» Interesting theory. Like a ‘pull-push’ sort of action. Which ironically is
» what I did the first time around but entirely by mistake.
» For the first 2 or 3 days I inhibited wnt as well as EGF. Then I changed
» to milk thistle and continued with the lithium to upregulate. The question
» is, was the wnt inhibition of the quercetin overwhelming the lithium.
I too have been wondering if your use of quercetin might be related to you having good results. Quercetin is meant to be an excellent antiinflamatory, and antihistamine. Maybe it even has other properties that are beneficial to the folica process?
now, this next bit is a bit far fetched… but humour me
I noticed that Quercetin strongly inhibits the enzyme CYP3A4. So i did a little research which got me thinking:
CYP3A4 is responsible for metabolising drugs in the body. if it is inhibited, the body takes longer to break down certain drugs, effectively increasing the body serum levels.
CYP3A4 isnt present in fetuses. A good enviroment for stem cells and hair genesis (might mean nothing, but thought i would add the fact for completeness)
When I looked through a list of enzyme substrates that CYP3A4 reacted with (theres a list on wikipedia too), I noticed a lot of the immunosupresents and the chemo drugs that people have been talking about.(gefitinib, ciclosporin,etc). It is also involved in the oxidisation of testosterone, and effects the availability of testosterone (and conversion to dihydrotestosterone i believe).
would using gefitnib and ciclosporin et al “use up” the CYP3A4 therby lowering its availability and promoting a ‘safer’ enviroment for hair folicle genesis? Combined with the strong anti-inflamatory and antihistamine effect, it may be significant.
or it may not… its all a bit grasping at straws, but it was enough to perk my interest so i thought i would share