Acell is Nothing

Stem cell; cell based hair therapy
21

» I’m not a researcher or biologist.
»
» I just research in my spare time via the web (advice check wiki, google)
»
» But I do know extracelluar matrix is universal, it regenerates “local
» tissue,” you will not get fur on a tendon, you put it on a tendon, it
» regenerates tendon, on a heart it regenerates heart, skin it regenerates
» skin, put it on a scalp it regenerates scalp.
»
» » » Research ECM and tell me that universal ECM is nothing. Tell me ECM
» » does
» » » not direct the traffic and control the laminin, stem cells etc.
» Turning
» » on
» » » things when needed when they are needed, turning things off when
» needed.
» »
» »
» » are you a researcher ( doctor, biologist ) ?
» » This is a hairloss forum, and this is not the HT section, so tell me
» the
» » connection between ECM products and regrowing hair on a bald scalp, how
» » would you do it ? who is trying it ? because I can tell you that we
» have
» » the follica trials and the HM trials to regrow hair on a bald scalp
»

What if you could get Acell deep enough to reach the hair follicles?

22

» I’m not a researcher or biologist.
»
» I just research in my spare time via the web (advice check wiki, google)

so we lack the fundamentals of these things

» But I do know extracelluar matrix is universal, it regenerates “local
» tissue,” you will not get fur on a tendon, you put it on a tendon, it
» regenerates tendon, on a heart it regenerates heart, skin it regenerates
» skin, put it on a scalp it regenerates scalp.

It’s not so easy, I will post this again, I found it at another forum :

" Dear Stephen,

Thanks for your inquiry. I am a colleague of Dr. Stephen Badylak and I
am helping him deal with the massive influx of inquiries following the
recent publicity on the use of extracellular matrix
(ECM) to facilitate the regeneration of a finger tip.
ECM has been used extensively; it is estimated that 1,500,000 patients
have been treated with some form of ECM. The predominate form of ECM
is sheet material, and some of the most prevalent applications are
hernia repair, treatment of pressure ulcers, and orthopaedic
procedures, such as rotator cuff, etc.
The powdered form use in the fingertip regeneration is strictly
experimental and has only been used on two patients.
It should be noted that the two success stories to date involved the
loss of the fingertip-above the first knuckle, and the nail bed was
not destroyed. We have no expectations that the current ECM
technology can regenerate joints (knuckles) or nail beds. We have no
relevant experience on the treatment of scar using ECM.
Dr. Badylak is investigating other applications of ECM, but the most
advanced research that I am aware of on the mitigation of scar is
being done by Intercytex in England; see http://www.intercytex.com/
and look at their Valveta video.
I hope this introduction helps and thank you for your interest.
The best place to follow developments in this area is on our web site
at www.mirm.pitt.edu

John
John N. Murphy
Executive Director-McGowan Institute & Research Professor-Chemical
Engineering
Phone: 412-235-5155
Fax: 412-235-5290
Email: jmurphy@pitt.edu

"

http://www.acne.org/messageboard/index.php?showtopic=157005&st=780&start=780

BTW, what does it mean that " put it on a scalp it regenerates scalp " ? please explain it, I’ve got a normal scalp with no wounds at all, do you want to scalp me ? :smiley:
How would you use it on a bald scalp ? Even if you can get acell to reach the follicle, how can you expect it to recognize that the follicle has to be “regenerated” ?, this is where I want to go, do you understand me ?

23

» » I’m not a researcher or biologist.
» »
» » I just research in my spare time via the web (advice check wiki,
» google)
»
» so we lack the fundamentals of these things
»
»
»
» » But I do know extracelluar matrix is universal, it regenerates “local
» » tissue,” you will not get fur on a tendon, you put it on a tendon, it
» » regenerates tendon, on a heart it regenerates heart, skin it
» regenerates
» » skin, put it on a scalp it regenerates scalp.
»
» It’s not so easy, I will post this again, I found it at another forum :
»
» " Dear Stephen,
»
»
» Thanks for your inquiry. I am a colleague of Dr. Stephen Badylak and I
» am helping him deal with the massive influx of inquiries following the
» recent publicity on the use of extracellular matrix
» (ECM) to facilitate the regeneration of a finger tip.
» ECM has been used extensively; it is estimated that 1,500,000 patients
» have been treated with some form of ECM. The predominate form of ECM
» is sheet material, and some of the most prevalent applications are
» hernia repair, treatment of pressure ulcers, and orthopaedic
» procedures, such as rotator cuff, etc.
» The powdered form use in the fingertip regeneration is strictly
» experimental and has only been used on two patients.
» It should be noted that the two success stories to date involved the
» loss of the fingertip-above the first knuckle, and the nail bed was
» not destroyed. We have no expectations that the current ECM
» technology can regenerate joints (knuckles) or nail beds. We have no
» relevant experience on the treatment of scar using ECM.
» Dr. Badylak is investigating other applications of ECM, but the most
» advanced research that I am aware of on the mitigation of scar is
» being done by Intercytex in England; see http://www.intercytex.com/
» and look at their Valveta video.
» I hope this introduction helps and thank you for your interest.
» The best place to follow developments in this area is on our web site
» at www.mirm.pitt.edu
»
» John
» John N. Murphy
» Executive Director-McGowan Institute & Research Professor-Chemical
» Engineering
» Phone: 412-235-5155
» Fax: 412-235-5290
» Email: jmurphy@pitt.edu
»
» "
»
» http://www.acne.org/messageboard/index.php?showtopic=157005&st=780&start=780
»
» BTW, what does it mean that " put it on a scalp it
» regenerates scalp " ? please explain it, I’ve got a normal scalp with no
» wounds at all, do you want to scalp me ? :smiley:
» How would you use it on a bald scalp ? Even if you can get acell to reach
» the follicle, how can you expect it to recognize that the follicle has to
» be “regenerated” ?, this is where I want to go, do you understand me
» ?

I meant put it on a scalp wound it regenerates scalp, put it on a strip wound it regenerates the tissue around it, put it on a tendon wound it regenerates tendon. It is universal, it regenerates what is locally around it. Our bodies always regenerate with it when we are not wounded.

The application has its safety certificate, the application does not need to have extra trials on anything…

Theone, in theory it will regenerate the local tissue that is wounded.

24

» » Research ECM and tell me that universal ECM is nothing. Tell me ECM
» does
» » not direct the traffic and control the laminin, stem cells etc. Turning
» on
» » things when needed when they are needed, turning things off when needed.
»
»
» are you a researcher ( doctor, biologist ) ?
» This is a hairloss forum, and this is not the HT section, so tell me the
» connection between ECM products and regrowing hair on a bald scalp, how
» would you do it ? who is trying it ? because I can tell you that we have
» the follica trials and the HM trials to regrow hair on a bald scalp

By the way Sceptic…what is your background. I’m just curious. My brother (who posts here often) has a masters degree in biology and is not sure whether this will work or not. Dr. Jones is using it for strip repair but David said in another post that he (Dr. Jones) hopes that it will regenerate hair. That would lead me to believe that he’s not sure what to expect. So, how can you be so sure what will happen?

25

fred123:
But I do know extracelluar matrix is universal, it regenerates “local tissue,” you will not get fur on a tendon, you put it on a tendon, it regenerates tendon, on a heart it regenerates heart, skin it regenerates skin, put it on a scalp it regenerates scalp.

TheOne:
What if you could get Acell deep enough to reach the hair follicles?

That’s what I’ve been saying for weeks (but it got lost among these threads). My question still remains: How can we get Acell to the depth of those dormant hair follicles, and does it actually have potential via stand-alone application? If not, could Acell be used in combination with something else to stimulate hair growth?

I was joking around with hanging about Aderans’ newest experiments on pigs, BUT than I started thinking about one line in their PDF.
“Cells were combined with Matrigel™ (a surrogate extracellular matrix) and implanted at various depths.”

Aderans used an extracellular matrix to improve the efficacy of their cell injections. Could we do the same with a combination of Acell (an extracellular matrix) along with Rogaine, or some other product (natural or otherwise). Could Acell act as a catalyst to improve the efficacy of currently available products? How could we make Acell more soluble? How would we get it to the depth of those dormant hair follicles?

.

26

» fred123:
» But I do know extracelluar matrix is universal, it regenerates “local
» tissue,” you will not get fur on a tendon, you put it on a tendon, it
» regenerates tendon, on a heart it regenerates heart, skin it regenerates
» skin, put it on a scalp it regenerates scalp.
»
» TheOne:
» What if you could get Acell deep enough to reach the hair
» follicles?
»
» That’s what I’ve been saying for weeks (but it got lost among these
» threads). My question still remains: How can we get Acell to the depth
» of those dormant hair follicles, and does it actually have potential via
» stand-alone application? If not, could Acell be used in combination with
» something else to stimulate hair growth?
»
» I was joking around with hanging about Aderans’ newest experiments on
» pigs, BUT than I started thinking about one line in their PDF.
» “Cells were combined with Matrigel™ (a surrogate extracellular matrix) and
» implanted at various depths.”
»
» Aderans used an extracellular matrix to improve the efficacy of their cell
» injections. Could we do the same with a combination of Acell (an
» extracellular matrix) along with Rogaine, or some other product (natural or
» otherwise). Could Acell act as a catalyst to improve the efficacy of
» currently available products? How could we make Acell more soluble? How
» would we get it to the depth of those dormant hair follicles?
»
»
»
»
» .

Rev,

I don’t know the answer to that question but thats why I think that it is important to get as many doctors as possible to try Acell. If many different doctors try it, hopefully it will be tried in many different ways. I am going to send the stock e-mail out again to all of the doctors on our e-mail list. It might be a good idea for members of the forum to explain several different methods that Acell could be used and send an e-mail to all of the doctors listing these methods. It might help to spark an idea in them that they haven’t thought of before (they’re only human). It would be a good idea to start this under a new thread and ask for input from other members.

Take Care,
Bill

27

Ok, I give up.

28

» fred123:
» But I do know extracelluar matrix is universal, it regenerates “local
» tissue,” you will not get fur on a tendon, you put it on a tendon, it
» regenerates tendon, on a heart it regenerates heart, skin it regenerates
» skin, put it on a scalp it regenerates scalp.
»
» TheOne:
» What if you could get Acell deep enough to reach the hair
» follicles?
»
» That’s what I’ve been saying for weeks (but it got lost among these
» threads). My question still remains: How can we get Acell to the depth
» of those dormant hair follicles, and does it actually have potential via
» stand-alone application? If not, could Acell be used in combination with
» something else to stimulate hair growth?
»
» I was joking around with hanging about Aderans’ newest experiments on
» pigs, BUT than I started thinking about one line in their PDF.
» “Cells were combined with Matrigel™ (a surrogate extracellular matrix) and
» implanted at various depths.”
»
» Aderans used an extracellular matrix to improve the efficacy of their cell
» injections. Could we do the same with a combination of Acell (an
» extracellular matrix) along with Rogaine, or some other product (natural or
» otherwise). Could Acell act as a catalyst to improve the efficacy of
» currently available products? How could we make Acell more soluble? How
» would we get it to the depth of those dormant hair follicles?
»
»
»
»
» .

I was thinking along the lines of the woman who used it to regenerate fresh skin to rid her self of stretch marks, those things can be pretty deep into the skin.

She did a chemical peel, mixed Acell-vet in emu oil and poof fresh skin. (she used Acell vet because at the time it was not yet released for human use)

So maybe a chemical peel is enough? or going pretty deep with needling? and then adding Acell to a carrier that can penetrate deep enough.
My hope (and a huge long shot) is that the follicles are damaged enough by MPB that Acell can work it’s regenerative powers on them, thers is also the possibility of Laminin 511/521.

29

» animals are covered in fur, etc.

Well, so are humans, in fact. Some of the hair is so small it’s not readily visible, but it’s there.

And I’m DEFINITELY covered in fur. Ask the missus.