» Spiro can be of no profit in many cases of androgenetic loss. Spiro cream
» caused a massive 3 month shed for me whereas finasteride is effective.
This means Spirnolactone was probably effective on you. Early shedding in hair loss treatment is often caused by the medication working. From another thread:
“Any hair that sheds within 2-4 months of starting a treatment was already in the loss-phase when treatment started and scheduled to fall out anyway. Medical treatment may accelerate this process a few weeks because new hair starting to grow may serve as a stimulous for loss-phase hair to shed a little early. Generally, this presents as a wave of shedding starting 3-6 weeks after starting treatment. The minoxidil package insert says as early as two weeks, but this is unusual. Typically, it lasts a month or so. Every treatment that brings follicles out of dormancy (which means every treatment that works) may do this in some persons. The faster the follicles get brought out of dormancy, the more likely you are to see it…”
“In any case, the hair was about to fall out anyway. If the shed is due to treatment, it is a good sign, since it means treatment is working. Thus, as distressing as it can be, an early shed tends to be associated with a good eventual result.”
Finally, while on paper Spironolactone is a much better antiandrogen than Finasteride, I do not think it works much better clinically. I prefer it because of lack of systemic side-effects, not because it works a lot better. better. So I am surprised that you had a shed on spironolactone and not on Finasteride. You may be the exception that responds better to spironolactone. Alternately, it may be that by the time you started finasteride, the spironolactone had already caused any excess loss-phase hair to shed.
Peter H. Proctor, PhD,MD