We’ll see soon enough. I’m not saying this isn’t a good product for burn victims, and others who lose skin. The question is will it be useful for restoring hair for people with MPB? I suspect it won’t, because I think the quality and quantity of the hair won’t be what we need.
Yes, it’s important for cells to experience “polarity” to regrow fully-functional skin. That means that the cells have to know which way is “up” and which way is “down”, as they did in the embryo when they were forming skin and other organs for the first time. In the embryo they experienced polarity by way of very complex chemical signaling coming from other cells situated 360 degrees around them, in a 3-dimensional matrix. So they were properly oriented in space, and that’s how they were able to use their genes to grow into properly situated 3-dimensional organs. That’s why, for instance, on your scalp, all the hairs are embedded in the dermis and grow OUT of your scalp, rather than some growing inward or in all different directions.
I suspect that this SkinTE product will solve some of that problem. It will allow the cells to form functional skin with fine hair, maybe even sweat glands, etc. in their proper orientation.
I just don’t think it will be close to perfect. I think this is still a young technology. SkinTE may have polarity on one axis (proximal to distal – that is, inward to outward). But maybe, because it lacks all of the very complicated chemical signaling of the developing embryo and fetus, it won’t have ALL the signaling and polarity it needs on all the axes it needs. My guess is hairs will grow, but they won’t be thick, full, terminal hairs with the appearance and density needed to give a person a full head of hair or fill in bald spots with quality hair.
I may be wrong about this, and we’ll soon see… If I am wrong, then great for all of us – we’ll all be very happy. But I suspect that is as far as this will go for now.